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Strain Name:
C57BL/6J-MtgxR6782Btlr/Mmmh
Stock Number:
044896-MU
Citation ID:
RRID:MMRRC_044896-MU
Other Names:
R6782 (G1)
Major Collection:

Strain Information

Npr1
Name: natriuretic peptide receptor 1
Synonyms: NPRA, GC-A, NPR-A, guanylyl cyclase-A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18160
HGNC: HGNC:7943
Homologene: 37367
Htr5b
Name: 5-hydroxytryptamine (serotonin) receptor 5B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15564
Homologene: 74951
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Esco2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms: D030072L07Rik, 2410004I17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71988
Homologene: 12432
Foxp1
Name: forkhead box P1
Synonyms: 4932443N09Rik, 3110052D19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108655
HGNC: HGNC:3823
Homologene: 13092
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079
Arl5b
Name: ADP-ribosylation factor-like 5B
Synonyms: 4930587A11Rik, Arl8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75869
Homologene: 101695
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 121,510,498 bp
  • A to G, chromosome 1 at 166,389,972 bp
  • A to G, chromosome 1 at 173,481,357 bp
  • A to T, chromosome 1 at 177,050,190 bp
  • A to G, chromosome 1 at 188,356,834 bp
  • T to C, chromosome 2 at 14,261,337 bp
  • A to G, chromosome 2 at 15,073,182 bp
  • T to G, chromosome 2 at 35,170,646 bp
  • C to T, chromosome 2 at 73,909,328 bp
  • A to G, chromosome 2 at 111,306,745 bp
  • T to C, chromosome 2 at 150,473,354 bp
  • G to A, chromosome 2 at 158,436,566 bp
  • T to C, chromosome 2 at 170,116,258 bp
  • TTCTCTCTCTCTCTCTCT to TTCTCTCTCTCTCTCT, chromosome 3 at 53,845,205 bp
  • T to C, chromosome 3 at 90,456,253 bp
  • T to C, chromosome 4 at 76,325,140 bp
  • A to C, chromosome 5 at 31,169,836 bp
  • T to C, chromosome 5 at 90,254,738 bp
  • A to T, chromosome 5 at 107,725,953 bp
  • A to T, chromosome 5 at 122,111,014 bp
  • T to C, chromosome 5 at 142,787,308 bp
  • T to C, chromosome 6 at 98,930,145 bp
  • G to A, chromosome 7 at 30,178,753 bp
  • A to C, chromosome 7 at 42,662,030 bp
  • G to A, chromosome 7 at 73,475,379 bp
  • A to G, chromosome 7 at 85,870,355 bp
  • A to G, chromosome 7 at 103,732,342 bp
  • T to C, chromosome 7 at 108,212,463 bp
  • T to G, chromosome 7 at 108,395,537 bp
  • A to G, chromosome 7 at 112,346,761 bp
  • C to T, chromosome 7 at 120,248,085 bp
  • G to A, chromosome 7 at 144,621,687 bp
  • A to G, chromosome 8 at 47,900,791 bp
  • A to G, chromosome 8 at 48,646,256 bp
  • A to G, chromosome 8 at 64,071,281 bp
  • T to C, chromosome 8 at 80,051,604 bp
  • T to A, chromosome 9 at 9,115,720 bp
  • A to T, chromosome 9 at 87,211,684 bp
  • C to T, chromosome 10 at 80,789,390 bp
  • T to C, chromosome 10 at 84,947,527 bp
  • A to T, chromosome 11 at 94,358,950 bp
  • A to G, chromosome 11 at 94,459,550 bp
  • A to G, chromosome 11 at 106,054,755 bp
  • T to C, chromosome 13 at 23,752,410 bp
  • T to A, chromosome 13 at 73,798,969 bp
  • G to T, chromosome 14 at 60,691,463 bp
  • T to C, chromosome 14 at 65,820,016 bp
  • T to A, chromosome 15 at 28,449,156 bp
  • C to A, chromosome 15 at 33,028,135 bp
  • T to A, chromosome 16 at 17,325,988 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • T to C, chromosome 16 at 50,200,565 bp
  • T to C, chromosome 17 at 20,356,879 bp
  • T to C, chromosome 17 at 65,500,124 bp
  • T to A, chromosome 18 at 77,431,177 bp
  • G to T, chromosome 19 at 50,176,122 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6782 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044896-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.