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Strain Name:
C57BL/6J-MtgxR6786Btlr/Mmmh
Stock Number:
044900-MU
Citation ID:
RRID:MMRRC_044900-MU
Other Names:
R6786 (G1)
Major Collection:

Strain Information

Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Tbx21
Name: T-box 21
Synonyms: Tblym, TBT1, T-bet, Tbet
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57765
Homologene: 8353
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Pik3ip1
Name: phosphoinositide-3-kinase interacting protein 1
Synonyms: 1500004A08Rik, 5830455E04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216505
Homologene: 14166
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, seal, motor end-plate disease, nmf2, ataxia 3, mnd2, mnd-2, C630029C19Rik, nmf58, NaCh6, Nav1.6, nmf335, NMF335, nur14
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 63,304,520 bp
  • C to T, chromosome 1 at 74,590,685 bp
  • A to T, chromosome 1 at 181,641,405 bp
  • A to G, chromosome 2 at 57,111,908 bp
  • A to G, chromosome 2 at 59,791,806 bp
  • G to A, chromosome 2 at 91,557,575 bp
  • AAGT to AAGTAGT, chromosome 2 at 98,663,803 bp
  • A to G, chromosome 2 at 115,631,981 bp
  • T to C, chromosome 2 at 146,045,443 bp
  • T to A, chromosome 2 at 164,820,851 bp
  • C to T, chromosome 2 at 178,383,552 bp
  • T to C, chromosome 3 at 14,886,650 bp
  • A to G, chromosome 3 at 19,672,774 bp
  • A to T, chromosome 3 at 126,958,932 bp
  • C to A, chromosome 4 at 56,744,116 bp
  • T to C, chromosome 4 at 56,771,555 bp
  • A to T, chromosome 4 at 73,403,606 bp
  • A to G, chromosome 4 at 96,762,821 bp
  • T to C, chromosome 4 at 99,061,292 bp
  • C to T, chromosome 4 at 119,237,954 bp
  • G to T, chromosome 4 at 154,892,428 bp
  • A to G, chromosome 5 at 70,754,267 bp
  • A to T, chromosome 5 at 109,427,829 bp
  • A to G, chromosome 5 at 110,009,740 bp
  • T to A, chromosome 5 at 136,567,231 bp
  • A to G, chromosome 6 at 34,095,587 bp
  • T to C, chromosome 6 at 83,296,747 bp
  • A to T, chromosome 6 at 142,364,552 bp
  • T to C, chromosome 7 at 5,195,962 bp
  • A to G, chromosome 7 at 46,378,317 bp
  • A to C, chromosome 7 at 101,992,638 bp
  • C to T, chromosome 8 at 13,370,485 bp
  • A to C, chromosome 8 at 47,186,465 bp
  • A to T, chromosome 8 at 84,727,647 bp
  • T to C, chromosome 8 at 87,472,029 bp
  • T to A, chromosome 8 at 99,223,947 bp
  • C to A, chromosome 8 at 109,948,100 bp
  • C to A, chromosome 8 at 111,080,940 bp
  • TCCC to TCC, chromosome 9 at 66,501,188 bp
  • T to A, chromosome 9 at 114,512,704 bp
  • G to A, chromosome 10 at 81,157,246 bp
  • C to T, chromosome 10 at 88,992,870 bp
  • T to C, chromosome 10 at 99,016,959 bp
  • A to G, chromosome 11 at 3,332,124 bp
  • A to T, chromosome 11 at 50,230,698 bp
  • A to G, chromosome 11 at 72,306,635 bp
  • T to A, chromosome 11 at 97,115,046 bp
  • A to T, chromosome 11 at 115,523,775 bp
  • G to A, chromosome 11 at 120,065,392 bp
  • A to T, chromosome 13 at 19,216,476 bp
  • T to A, chromosome 13 at 40,728,754 bp
  • T to C, chromosome 13 at 67,708,011 bp
  • G to T, chromosome 14 at 52,226,668 bp
  • G to T, chromosome 14 at 52,314,621 bp
  • G to A, chromosome 14 at 53,831,665 bp
  • A to T, chromosome 14 at 56,206,995 bp
  • T to C, chromosome 15 at 85,818,649 bp
  • A to C, chromosome 15 at 101,032,215 bp
  • A to T, chromosome 16 at 18,283,829 bp
  • A to T, chromosome 17 at 20,182,838 bp
  • C to T, chromosome 17 at 22,145,769 bp
  • C to T, chromosome 17 at 35,171,496 bp
  • T to C, chromosome 17 at 35,623,165 bp
  • G to A, chromosome 18 at 22,525,440 bp
  • A to G, chromosome 18 at 65,306,634 bp
  • A to G, chromosome 18 at 80,129,745 bp
  • T to C, chromosome 19 at 13,103,203 bp
  • T to A, chromosome 19 at 21,555,764 bp
  • A to T, chromosome 19 at 25,183,022 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6786 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044900-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.