Strain Name:
C57BL/6J-MtgxR6825Btlr/Mmmh
Stock Number:
044937-MU
Citation ID:
RRID:MMRRC_044937-MU
Other Names:
R6825 (G1)
Major Collection:

Strain Information

Card11
Name: caspase recruitment domain family, member 11
Synonyms: BIMP3, 2410011D02Rik, CARMA1, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Upp1
Name: uridine phosphorylase 1
Synonyms: Up, UPase, UdRPase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22271
Homologene: 2524
Lhx9
Name: LIM homeobox protein 9
Synonyms: LH2B, 3110009O07Rik, Lhx9 alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16876
Homologene: 7816
Efr3a
Name: EFR3 homolog A
Synonyms: C920006C10Rik, A130089M23Rik, D030063F01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76740
Homologene: 44222
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711
Tdh
Name: L-threonine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58865
Homologene: 10987
Epb41l5
Name: erythrocyte membrane protein band 4.1 like 5
Synonyms: 1700030C16Rik, Lulu1, NBL5, Epb4.1l5, E230025E14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226352
Homologene: 32492
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, PlexA1, 2600013D04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, ALL-1, Mll1, Cxxc7, Mll, HTRX1, All1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Ankle2
Name: ankyrin repeat and LEM domain containing 2
Synonyms: 1110001J12Rik, D5Ertd585e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71782
Homologene: 35424
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 2610040L17Rik, 9330187F13Rik, D3Bwg1534e, Ten-m2, Odz2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Cit
Name: citron
Synonyms: citron kinase, Cit-k, CRIK-SK, C030025P15Rik, citron-N
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Mgat4a
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms: GnT-IVa, 9530018I07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269181
HGNC: HGNC:7047
Homologene: 8153
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Pex5
Name: peroxisomal biogenesis factor 5
Synonyms: ESTM1, Pxr1, PTS1R, peroxisome biogenesis factor 5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19305
HGNC: HGNC:9719
Homologene: 270
Helq
Name: helicase, POLQ-like
Synonyms: D430018E21Rik, Hel308
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 191578
Homologene: 14667
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: TZK, ZAP-70, Srk
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22637
Homologene: 839
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Phlda3
Name: pleckstrin homology like domain, family A, member 3
Synonyms: TDAG/lpl homolog 1, Tih1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27280
HGNC: HGNC:8934
Homologene: 8233
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272347
Homologene: 12358
Cul2
Name: cullin 2
Synonyms: 1300003D18Rik, 4932411N15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71745
HGNC: HGNC:2552
Homologene: 2662
Ercc8
Name: excision repaiross-complementing rodent repair deficiency, complementation group 8
Synonyms: Csa, B130065P18Rik, 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, Ckn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71991
HGNC: HGNC:3439
Homologene: 62
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 2410140K03Rik, D5Ertd591e, A630018G05Rik, 3110031A07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Tcerg1
Name: transcription elongation regulator 1 (CA150)
Synonyms: ca150, Fbp28, 2900090C16Rik, 2410022J09Rik, p144, Taf2s
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 56070
Homologene: 4879
Arpc1a
Name: actin related protein 2/3 complex, subunit 1A
Synonyms: Sid32, 0610010H08Rik, 1110030K07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56443
HGNC: HGNC:703
Homologene: 4675
Prkaa1
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms: AMPKalpha1, C130083N04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105787
VEGA: 15
HGNC: HGNC:9376
Homologene: 49590
Fbxl19
Name: F-box and leucine-rich repeat protein 19
Synonyms: Fbl19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233902
Homologene: 129692
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: STAMP, 4930556H18Rik, 2310009M18Rik, 1700048H13Rik, D630041K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: CD103, alpha-E1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Frmd4b
Name: FERM domain containing 4B
Synonyms: GRSP1, 6030440G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232288
Homologene: 14916
Clcn2
Name: chloride channel, voltage-sensitive 2
Synonyms: nmf240, Clc2, ClC-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12724
HGNC: HGNC:2020
Homologene: 3213
Gas6
Name: growth arrest specific 6
Synonyms: Gas-6, GAS 6, growth arrest-specific
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14456
HGNC: HGNC:4168
Homologene: 638
Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Synonyms: CP12, P450-3, aromatic compound inducible
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13077
VEGA: 9
HGNC: HGNC:2596
Homologene: 68082
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232748
Homologene: 17147
Arhgef5
Name: Rho guanine nucleotide exchange factor 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54324
Homologene: 66300
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist, Egfr-rs, Dist1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13650
Homologene: 32085
Tns1
Name: tensin 1
Synonyms: Tns, E030018G17Rik, E030037J05Rik, 1110018I21Rik, 1200014E20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: SemG, SemG, Semag
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20357
Homologene: 8427
Adam10
Name: a disintegrin and metallopeptidase domain 10
Synonyms: kuzbanian, kuz, 1700031C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11487
HGNC: HGNC:188
Homologene: 865
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cebpa-rs1, CBF2, Cbf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12607
VEGA: 17
Homologene: 4210
Faxc
Name: failed axon connections homolog
Synonyms: 6230409E13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76132
Homologene: 32781
Pold4
Name: polymerase (DNA-directed), delta 4
Synonyms: p12, DNA polymerase delta smallest subunit p12, 2410012M21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69745
VEGA: 19
Homologene: 10909
Fut9
Name: fucosyltransferase 9
Synonyms: mFUT9, mFuc-TIX
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14348
HGNC: HGNC:4020
Homologene: 4800
Or4c104
Name: olfactory receptor family 4 subfamily C member 104
Synonyms: GA_x6K02T2Q125-50231574-50230642, MOR230-8, Olfr1199
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258450
Homologene: 128092
H2-Q1
Name: histocompatibility 2, Q region locus 1
Synonyms: Q1, Q1k, Q1d, Q1b, H-2Q1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15006
Homologene: 128352
Cyp3a44
Name: cytochrome P450, family 3, subfamily a, polypeptide 44
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 337924
HGNC: HGNC:2638
Homologene: 133568
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53791
Homologene: 20698
Prl7d1
Name: prolactin family 7, subfamily d, member 1
Synonyms: Plfr, PLF-RP, PRP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18814
Homologene: 7894
4930447C04Rik
Name: RIKEN cDNA 4930447C04 gene
Synonyms: Six6as, Six6os1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75801
Homologene: 49922
Or5b3
Name: olfactory receptor family 5 subfamily B member 3
Synonyms: Olfr1469, MOR202-11, GA_x6K02T2RE5P-3743369-3744289
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258690
HGNC: HGNC:8324
Homologene: 133675
Vamp5
Name: vesicle-associated membrane protein 5
Synonyms: Camp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53620
Homologene: 4833
Rab3gap1
Name: RAB3 GTPase activating protein subunit 1
Synonyms: p130, 1700003B17Rik, 4732493F09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226407
Homologene: 45617
Hepacam
Name: hepatocyte cell adhesion molecule
Synonyms: 2900042E01Rik, Glialcam
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72927
Homologene: 17652
Rpl18a
Name: ribosomal protein L18A
Synonyms: 2510019J09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76808
Homologene: 68104
Csf3
Name: colony stimulating factor 3 (granulocyte)
Synonyms: Csfg, MGI-IG, G-CSF
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12985
HGNC: HGNC:2438
Homologene: 7677
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66396
VEGA: 9
Homologene: 11678
Tomm5
Name: translocase of outer mitochondrial membrane 5
Synonyms: 1110019J04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68512
Homologene: 104342
Or2t43
Name: olfactory receptor family 2 subfamily T member 43
Synonyms: Olfr327-ps1, GA_x6K02T00261-652-347, GA_x6K02T2NKPP-858022-858862, MOR275-10_p, Olfr224, MOR275-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258198
Homologene: 133015
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,778,390 bp
  • T to A, chromosome 1 at 37,464,434 bp
  • G to T, chromosome 1 at 74,002,323 bp
  • A to T, chromosome 1 at 119,620,201 bp
  • T to C, chromosome 1 at 127,930,421 bp
  • T to C, chromosome 1 at 135,766,824 bp
  • ACC to ACCC, chromosome 1 at 138,841,806 bp
  • A to T, chromosome 1 at 182,973,044 bp
  • T to C, chromosome 2 at 88,755,911 bp
  • T to C, chromosome 4 at 21,931,672 bp
  • A to T, chromosome 4 at 25,619,925 bp
  • A to T, chromosome 4 at 45,106,443 bp
  • A to T, chromosome 4 at 123,383,222 bp
  • A to T, chromosome 5 at 32,828,548 bp
  • A to T, chromosome 5 at 76,888,849 bp
  • A to T, chromosome 5 at 100,792,695 bp
  • A to T, chromosome 5 at 110,250,769 bp
  • A to T, chromosome 5 at 115,981,774 bp
  • C to A, chromosome 5 at 140,878,082 bp
  • A to G, chromosome 5 at 143,727,807 bp
  • A to T, chromosome 5 at 145,096,126 bp
  • G to A, chromosome 5 at 145,779,586 bp
  • C to T, chromosome 6 at 42,629,518 bp
  • C to T, chromosome 6 at 43,274,961 bp
  • A to G, chromosome 6 at 47,866,331 bp
  • G to A, chromosome 6 at 48,465,525 bp
  • G to A, chromosome 6 at 72,380,441 bp
  • G to T, chromosome 6 at 89,320,615 bp
  • A to G, chromosome 6 at 97,325,476 bp
  • A to T, chromosome 6 at 124,414,381 bp
  • T to A, chromosome 7 at 127,750,015 bp
  • T to C, chromosome 8 at 13,483,674 bp
  • A to C, chromosome 8 at 70,896,192 bp
  • G to T, chromosome 9 at 13,251,976 bp
  • A to G, chromosome 9 at 37,367,680 bp
  • G to A, chromosome 9 at 44,818,407 bp
  • G to A, chromosome 9 at 57,677,260 bp
  • G to T, chromosome 9 at 70,761,602 bp
  • T to A, chromosome 11 at 9,131,707 bp
  • C to T, chromosome 11 at 32,209,970 bp
  • T to C, chromosome 11 at 36,046,884 bp
  • T to C, chromosome 11 at 58,566,650 bp
  • T to C, chromosome 11 at 73,118,496 bp
  • G to C, chromosome 11 at 98,702,447 bp
  • A to T, chromosome 12 at 72,907,880 bp
  • A to T, chromosome 12 at 85,883,328 bp
  • T to G, chromosome 13 at 27,710,142 bp
  • T to C, chromosome 13 at 108,158,809 bp
  • G to A, chromosome 14 at 63,495,832 bp
  • A to T, chromosome 15 at 5,143,950 bp
  • A to T, chromosome 15 at 27,889,308 bp
  • G to A, chromosome 15 at 65,829,830 bp
  • C to A, chromosome 16 at 20,709,658 bp
  • C to A, chromosome 16 at 35,628,007 bp
  • T to C, chromosome 17 at 30,741,173 bp
  • T to C, chromosome 17 at 35,321,052 bp
  • T to C, chromosome 17 at 78,919,963 bp
  • T to A, chromosome 18 at 3,434,946 bp
  • A to G, chromosome 18 at 42,548,477 bp
  • A to T, chromosome 19 at 4,232,110 bp
  • G to A, chromosome 19 at 13,411,150 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6825 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044937-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.