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Strain Name:
C57BL/6J-MtgxR6831Btlr/Mmmh
Stock Number:
044941-MU
Citation ID:
RRID:MMRRC_044941-MU
Other Names:
R6831 (G1)
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Glrx3
Name: glutaredoxin 3
Synonyms: PKC interacting cousin of thioredoxin, PICOT, Txnl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30926
Homologene: 4769
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,349,864 bp
  • T to A, chromosome 1 at 34,190,684 bp
  • C to T, chromosome 1 at 65,014,672 bp
  • G to A, chromosome 1 at 87,596,733 bp
  • T to A, chromosome 1 at 87,701,476 bp
  • T to A, chromosome 1 at 136,144,758 bp
  • G to A, chromosome 1 at 150,770,293 bp
  • A to G, chromosome 2 at 76,771,502 bp
  • A to T, chromosome 2 at 90,460,647 bp
  • C to T, chromosome 2 at 102,614,931 bp
  • T to A, chromosome 4 at 101,836,897 bp
  • C to T, chromosome 5 at 14,788,429 bp
  • A to T, chromosome 5 at 33,433,803 bp
  • T to A, chromosome 5 at 113,280,380 bp
  • T to A, chromosome 5 at 120,493,066 bp
  • T to C, chromosome 5 at 123,700,909 bp
  • A to T, chromosome 6 at 38,332,168 bp
  • A to G, chromosome 6 at 43,280,999 bp
  • G to A, chromosome 6 at 48,484,833 bp
  • G to A, chromosome 6 at 146,112,429 bp
  • T to C, chromosome 7 at 30,540,356 bp
  • G to C, chromosome 7 at 43,023,580 bp
  • T to C, chromosome 7 at 68,207,319 bp
  • A to G, chromosome 7 at 105,056,879 bp
  • A to T, chromosome 7 at 106,752,571 bp
  • C to T, chromosome 7 at 137,459,222 bp
  • T to C, chromosome 8 at 84,571,231 bp
  • C to T, chromosome 9 at 15,915,061 bp
  • C to A, chromosome 9 at 16,376,551 bp
  • G to C, chromosome 9 at 59,675,115 bp
  • T to A, chromosome 9 at 71,162,420 bp
  • T to A, chromosome 9 at 111,377,899 bp
  • T to C, chromosome 10 at 21,341,868 bp
  • T to G, chromosome 10 at 29,224,679 bp
  • T to G, chromosome 10 at 93,527,256 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • T to C, chromosome 11 at 51,070,554 bp
  • G to A, chromosome 11 at 73,710,608 bp
  • A to G, chromosome 11 at 97,706,902 bp
  • T to A, chromosome 12 at 75,966,794 bp
  • T to C, chromosome 12 at 91,266,974 bp
  • T to G, chromosome 13 at 27,059,547 bp
  • T to C, chromosome 13 at 96,495,491 bp
  • T to C, chromosome 14 at 24,296,095 bp
  • T to C, chromosome 14 at 33,632,925 bp
  • C to T, chromosome 14 at 68,618,127 bp
  • G to C, chromosome 15 at 28,411,515 bp
  • A to G, chromosome 15 at 85,895,006 bp
  • A to T, chromosome 16 at 20,608,747 bp
  • A to G, chromosome 16 at 52,309,901 bp
  • T to A, chromosome 17 at 29,887,516 bp
  • T to A, chromosome 17 at 67,756,754 bp
  • T to A, chromosome 18 at 62,180,545 bp
  • C to A, chromosome 18 at 62,950,126 bp
  • T to A, chromosome 19 at 5,160,795 bp
  • T to A, chromosome 19 at 6,910,195 bp
  • A to T, chromosome 19 at 38,207,289 bp
  • G to A, chromosome 19 at 47,283,093 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6831 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044941-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.