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Strain Name:
C57BL/6J-MtgxR6841Btlr/Mmmh
Stock Number:
044947-MU
Citation ID:
RRID:MMRRC_044947-MU
Other Names:
R6841 (G1)
Major Collection:

Strain Information

Fxyd6
Name: FXYD domain-containing ion transport regulator 6
Synonyms: 0610030I18Rik, Php
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59095
VEGA: 9
HGNC: HGNC:4030
Homologene: 11090
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: aldosterone synthase, Cyp11b-2, Cyp11b, steroid-11-beta-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75786
Homologene: 8844
Wdr59
Name: WD repeat domain 59
Synonyms: 5430401O09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319481
Homologene: 38685
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, CHAK1, CHAK, TRP-PLIK, Ltpr7, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Cstf3
Name: cleavage stimulation factor, 3' pre-RNA, subunit 3
Synonyms: 4732468G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228410
HGNC: HGNC:2485
Homologene: 1014
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: BUB2-like protein 1, HBLP1, AD3, GRAM domain
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54610
Homologene: 31421
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, IP3R1, Itpr-1, Ip3r, Pcp-1, opt, InsP3R type I, Pcp1, wblo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Cep85
Name: centrosomal protein 85
Synonyms: 2410030J07Rik, Ccdc21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70012
Homologene: 11254
Dhx8
Name: DEAH-box helicase 8
Synonyms: mDEAH6, RNA helicase, Ddx8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217207
HGNC: HGNC:2749
Homologene: 3628
Ipo9
Name: importin 9
Synonyms: 0710008K06Rik, Imp9
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226432
Homologene: 5874
Ticam2
Name: TIR domain containing adaptor molecule 2
Synonyms: TRAM, Tirp
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225471
Homologene: 11014
Htr2b
Name: 5-hydroxytryptamine (serotonin) receptor 2B
Synonyms: 5-HT2B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15559
HGNC: HGNC:5294
Homologene: 55492
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Ttc23
Name: tetratricopeptide repeat domain 23
Synonyms: 1600012K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67009
Homologene: 11289
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Hoxd10
Name: homeobox D10
Synonyms: Hox-4.5, Hox-5.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15430
HGNC: HGNC:5133
Homologene: 1619
Mrpl2
Name: mitochondrial ribosomal protein L2
Synonyms: MRP-L14, CGI-22, Rpml14
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27398
Homologene: 69198
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Map3k2
Name: mitogen-activated protein kinase kinase kinase 2
Synonyms: Mekk2, MEK kinase 2, 9630061B06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26405
VEGA: 18
HGNC: HGNC:6854
Homologene: 74576
Vps26b
Name: VPS26 retromer complex component B
Synonyms: 1810012I05Rik, 2310075A12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69091
VEGA: 9
Homologene: 3601
Elfn1
Name: leucine rich repeat and fibronectin type III, extracellular 1
Synonyms: A930017N06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243312
Homologene: 18465
Cars2
Name: cysteinyl-tRNA synthetase 2, mitochondrial
Synonyms: D530030H10Rik, 2310051N18Rik, 2410044A07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71941
Homologene: 11575
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: connectin, L56, 1100001C23Rik, mdm, 2310036G12Rik, D830007G01Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213121
Homologene: 16977
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Commd6
Name: COMM domain containing 6
Synonyms: 1700063H17Rik, 1110059J08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66200
Homologene: 52572
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Dynap
Name: dynactin associated protein
Synonyms: 2310002L13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75577
VEGA: 18
Homologene: 82463
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Mogat1
Name: monoacylglycerol O-acyltransferase 1
Synonyms: 0610030A14Rik, mDC2, MGAT1, Dgat2l1, 1110064N14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68393
Homologene: 105237
Cyp2d40
Name: cytochrome P450, family 2, subfamily d, polypeptide 40
Synonyms: 1300013D18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71754
VEGA: 15
Homologene: 135470
Ildr2
Name: immunoglobulin-like domain containing receptor 2
Synonyms: 3110063L10Rik, 2810478N18Rik, OTTMUSG00000021748, ENSMUSG00000040612, Dbsm1, D1Ertd471e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100039795
Homologene: 52388
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11981
Homologene: 69194
I830077J02Rik
Name: RIKEN cDNA I830077J02 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433638
Homologene: 45482
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Tyro 12, Nyk, Eyk, Mer, nmf12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Nxpe3
Name: neurexophilin and PC-esterase domain family, member 3
Synonyms: LOC208684, LOC385658, Fam55c
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385658
VEGA: 16
Homologene: 17030
Has1
Name: hyaluronan synthase 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15116
VEGA: 17
HGNC: HGNC:4818
Homologene: 1165
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, LGR8, Gpr106
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140498
Homologene: 15402
Cdk5r1
Name: cyclin dependent kinase 5, regulatory subunit 1
Synonyms: p35, D11Bwg0379e, p25
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12569
HGNC: HGNC:1775
Homologene: 31200
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: C80741, 2310041G17Rik, Tm7sf1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Skint8
Name: selection and upkeep of intraepithelial T cells 8
Synonyms: OTTMUSG00000009475
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 639774
Homologene: 106613
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Pdia2
Name: protein disulfide isomerase associated 2
Synonyms: 1810041F13Rik, Pdipl, Pdip
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69191
Homologene: 55994
Mgat2
Name: mannoside acetylglucosaminyltransferase 2
Synonyms: GNT-II, CDGS2, GNT2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217664
HGNC: HGNC:7045
Homologene: 1806
Acads
Name: acyl-Coenzyme A dehydrogenase, short chain
Synonyms: SCAD, Bcd-1, Bcd1, Hdlq8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11409
HGNC: HGNC:90
Homologene: 20057
Cblc
Name: Casitas B-lineage lymphoma c
Synonyms: Cbl3, 2310079L19Rik, 2310076I21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80794
Homologene: 8108
Ugt2b34
Name: UDP glucuronosyltransferase 2 family, polypeptide B34
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100727
Homologene: 117389
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: 9130020O16Rik, Gpr128
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Duoxa1
Name: dual oxidase maturation factor 1
Synonyms: Nip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213696
Homologene: 16043
Tpp1
Name: tripeptidyl peptidase I
Synonyms: Cln2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12751
HGNC: HGNC:2073
Homologene: 335
Top1mt
Name: DNA topoisomerase 1, mitochondrial
Synonyms: 2900052H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72960
Homologene: 43082
Timp3
Name: tissue inhibitor of metalloproteinase 3
Synonyms: Timp-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21859
Homologene: 36322
Klra4
Name: killer cell lectin-like receptor, subfamily A, member 4
Synonyms: Chok, Ly49d, ly49r129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16635
Homologene: 110821
Cnot11
Name: CCR4-NOT transcription complex, subunit 11
Synonyms: 2410015L18Rik, D1Bwg0212e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 52846
Homologene: 9711
Slc35a3
Name: solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
Synonyms: 2310050P13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229782
Homologene: 40826
Ccdc198
Name: coiled-coil domain containing 198
Synonyms: 1700011H14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67082
Homologene: 49528
Gpsm3
Name: G-protein signalling modulator 3 (AGS3-like, C. elegans)
Synonyms: AGS4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106512
Homologene: 11136
Pcmtd2
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Synonyms: 5330414D10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245867
Homologene: 10099
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Uqcrb
Name: ubiquinol-cytochrome c reductase binding protein
Synonyms: QP-C, 2210415M14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67530
Homologene: 38164
A730071L15Rik
Name: RIKEN cDNA A730071L15Rik gene
Type: Gene
Species: Mouse
Chromosome: 11
Crygc
Name: crystallin, gamma C
Synonyms: Cryg-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12966
HGNC: HGNC:2410
Homologene: 36281
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 12,838,434 bp
  • T to C, chromosome 1 at 39,389,374 bp
  • C to T, chromosome 1 at 39,540,067 bp
  • C to T, chromosome 1 at 65,073,202 bp
  • T to C, chromosome 1 at 78,522,859 bp
  • T to A, chromosome 1 at 86,099,893 bp
  • T to C, chromosome 1 at 135,386,308 bp
  • C to G, chromosome 1 at 166,270,575 bp
  • A to G, chromosome 2 at 19,201,819 bp
  • T to A, chromosome 2 at 70,020,625 bp
  • T to A, chromosome 2 at 74,692,272 bp
  • T to C, chromosome 2 at 76,884,952 bp
  • T to A, chromosome 2 at 76,896,590 bp
  • T to A, chromosome 2 at 91,570,252 bp
  • A to G, chromosome 2 at 104,655,731 bp
  • G to T, chromosome 2 at 122,303,981 bp
  • A to T, chromosome 2 at 126,813,021 bp
  • A to G, chromosome 2 at 128,759,230 bp
  • C to A, chromosome 2 at 168,654,220 bp
  • T to G, chromosome 2 at 181,844,438 bp
  • A to G, chromosome 3 at 37,021,481 bp
  • T to C, chromosome 3 at 96,656,714 bp
  • T to A, chromosome 3 at 96,670,426 bp
  • T to C, chromosome 3 at 105,926,514 bp
  • T to A, chromosome 3 at 116,712,768 bp
  • T to C, chromosome 4 at 111,928,771 bp
  • C to G, chromosome 4 at 134,155,856 bp
  • C to T, chromosome 5 at 86,892,816 bp
  • A to G, chromosome 5 at 96,728,551 bp
  • G to A, chromosome 5 at 115,112,358 bp
  • G to T, chromosome 5 at 139,973,145 bp
  • A to T, chromosome 5 at 150,018,745 bp
  • A to T, chromosome 6 at 48,597,925 bp
  • A to G, chromosome 6 at 108,388,192 bp
  • C to A, chromosome 6 at 130,065,199 bp
  • A to G, chromosome 7 at 19,792,896 bp
  • A to T, chromosome 7 at 64,364,629 bp
  • A to G, chromosome 7 at 67,669,728 bp
  • G to A, chromosome 7 at 105,748,964 bp
  • C to T, chromosome 8 at 11,516,198 bp
  • G to C, chromosome 8 at 110,538,375 bp
  • A to G, chromosome 8 at 111,496,880 bp
  • A to G, chromosome 9 at 27,010,464 bp
  • T to A, chromosome 9 at 45,391,553 bp
  • T to C, chromosome 10 at 74,450,220 bp
  • T to C, chromosome 10 at 86,345,774 bp
  • T to A, chromosome 10 at 86,942,190 bp
  • T to C, chromosome 10 at 92,875,015 bp
  • G to A, chromosome 11 at 6,200,439 bp
  • T to A, chromosome 11 at 80,478,195 bp
  • T to A, chromosome 11 at 101,764,792 bp
  • C to T, chromosome 11 at 119,449,866 bp
  • T to A, chromosome 12 at 69,185,633 bp
  • A to T, chromosome 13 at 13,363,509 bp
  • A to G, chromosome 13 at 66,900,763 bp
  • T to C, chromosome 14 at 49,243,813 bp
  • A to T, chromosome 14 at 101,637,098 bp
  • G to T, chromosome 15 at 74,855,491 bp
  • C to T, chromosome 15 at 75,676,124 bp
  • T to C, chromosome 15 at 82,761,486 bp
  • T to C, chromosome 16 at 55,844,322 bp
  • T to A, chromosome 16 at 56,750,424 bp
  • A to T, chromosome 17 at 12,703,376 bp
  • C to T, chromosome 17 at 17,843,860 bp
  • A to T, chromosome 17 at 26,196,604 bp
  • A to T, chromosome 17 at 34,590,562 bp
  • A to T, chromosome 17 at 46,647,456 bp
  • T to A, chromosome 18 at 32,226,629 bp
  • A to C, chromosome 18 at 46,560,931 bp
  • A to T, chromosome 18 at 70,241,182 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6841 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044947-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.