Strain Name:
C57BL/6J-MtgxR6842Btlr/Mmmh
Stock Number:
044948-MU
Citation ID:
RRID:MMRRC_044948-MU
Other Names:
R6842 (G1)
Major Collection:

Strain Information

Cbfa2t2
Name: CBFA2/RUNX1 translocation partner 2
Synonyms: C330013D05Rik, MTGR1, Cbfa2t2h
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12396
HGNC: HGNC:1536
Homologene: 3733
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: Spar, 4931426N11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: 5430402I23Rik, LEC3, Lphn3, D130075K09Rik, lectomedin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Armh3
Name: armadillo-like helical domain containing 3
Synonyms: 9130011E15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71617
VEGA: 19
Homologene: 15843
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: 2310020L09Rik, LOC383951
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Ddx19a
Name: DEAD box helicase 19a
Synonyms: DBP5, Eif4a-rs1, Ddx19, DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13680
Homologene: 5240
Utp6
Name: UTP6 small subunit processome component
Synonyms: 4732497O03Rik, HCA66
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216987
Homologene: 41265
Nav2
Name: neuron navigator 2
Synonyms: 5330421F07Rik, Unc53H2, HELAD1, RAINB2, Rainb1, POMFIL2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Cep85
Name: centrosomal protein 85
Synonyms: Ccdc21, 2410030J07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70012
Homologene: 11254
Msr1
Name: macrophage scavenger receptor 1
Synonyms: SR-AII, MRS-A, Scara1, Scvr, SR-AI, MSR-A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20288
HGNC: HGNC:7376
Homologene: 12822
Prdx6
Name: peroxiredoxin 6
Synonyms: Lvtw-4, Ltw4, 9430088D19Rik, Brp-12, 1-Cys Prx, GPx, Aop2, NSGP, CC26, aiPLA2, acidic calcium-independent phospholipase A2, CP-3, Ltw-4, 1-cysPrx
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11758
Homologene: 3606
Lypla1
Name: lysophospholipase 1
Synonyms: Pla1a, Gm39587
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18777
HGNC: HGNC:6737
Homologene: 100781
Trim66
Name: tripartite motif-containing 66
Synonyms: Tif1d, D7H11orf29
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330627
Homologene: 28044
Fgfr1op2
Name: FGFR1 oncogene partner 2
Synonyms: 1500031J01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67529
Homologene: 9222
Fbxl5
Name: F-box and leucine-rich repeat protein 5
Synonyms: Fbl4, Fir4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242960
Homologene: 8129
Sgk3
Name: serum/glucocorticoid regulated kinase 3
Synonyms: cytokine-independent survival kinase, Cisk, 2510015P22Rik, A330005P07Rik, fy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170755
Homologene: 56582
Mme
Name: membrane metallo endopeptidase
Synonyms: NEP, CD10, 6030454K05Rik, neprilysin, neutral endopeptidase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Tgfbr1
Name: transforming growth factor, beta receptor I
Synonyms: TbetaRI, TbetaR-I, ALK5, Alk-5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21812
Homologene: 3177
Pax1
Name: paired box 1
Synonyms: Pax-1, wt, hunchback, wavy tail, hbs
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Ccdc127
Name: coiled-coil domain containing 127
Synonyms: 0610011N22Rik, 5430420E17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67433
Homologene: 11482
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: 4832426G23Rik, Myhs-p, Myhsp, MyHC-pn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Fbxw26
Name: F-box and WD-40 domain protein 26
Synonyms: Gm5163
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382109
Homologene: 110776
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: Armc4, 4930463I21Rik, b2b643Clo, b2b227.1Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Cap2
Name: cyclase associated actin cytoskeleton regulatory protein 2
Synonyms: 2810452G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67252
Homologene: 101397
Or13f5
Name: olfactory receptor family 13 subfamily F member 5
Synonyms: GA_x6K02T2N78B-7168533-7167574, Olfr275, MOR262-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258857
Homologene: 17418
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Or8b12i
Name: olfactory receptor family 8 subfamily B member 12I
Synonyms: Olfr870, MOR141-1, GA_x6K02T2PVTD-13912679-13911744
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57251
Homologene: 138319
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 1700048E19Rik, 2610014F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72137
Homologene: 17609
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: alpha1E, Cav2.3, Cchra1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Mmp1b
Name: matrix metallopeptidase 1b (interstitial collagenase)
Synonyms: Mcol-B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83996
HGNC: HGNC:7155
Homologene: 130791
Acsbg3
Name: acyl-CoA synthetase bubblegum family member 3
Synonyms: 1700061G19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78625
Homologene: 28378
Or2ag12
Name: olfactory receptor family 2 subfamily AG member 12
Synonyms: MOR283-8, GA_x6K02T2PBJ9-9055944-9054994, Olfr693
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258445
Zfp956
Name: zinc finger protein 956
Synonyms: AI894139
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101197
Homologene: 128449
Ocm
Name: oncomodulin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18261
Homologene: 4511
Plbd1
Name: phospholipase B domain containing 1
Synonyms: 1100001H23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66857
Homologene: 11745
Klhdc10
Name: kelch domain containing 10
Synonyms: 2410127E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76788
Homologene: 15267
Oas1g
Name: 2'-5' oligoadenylate synthetase 1G
Synonyms: Oas1a, Mmu-L2, Oias1, Mmu-L, Oias-1, L2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23960
HGNC: HGNC:8086
Homologene: 1903
Cela3a
Name: chymotrypsin-like elastase family, member 3A
Synonyms: Gm13011
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242711
Homologene: 129880
C1s2
Name: complement component 1, s subcomponent 2
Synonyms: Gm5077
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 317677
HGNC: HGNC:1247
Homologene: 1314
Wfikkn2
Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Synonyms: 2610304F08Rik, Gasp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 278507
Homologene: 35284
Or8a1b
Name: olfactory receptor family 8 subfamily A member 1B
Synonyms: MOR171-3, GA_x6K02T2PVTD-31389446-31388517, MOR171-3, M72, Olfr160
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80706
HGNC: HGNC:8469
Homologene: 12726
Ighv1-37
Name: immunoglobulin heavy variable 1-37
Synonyms: Gm16716
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668517
HGNC: HGNC:5553
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 4,832,340 bp
  • T to C, chromosome 1 at 9,898,754 bp
  • A to G, chromosome 1 at 154,483,117 bp
  • A to T, chromosome 1 at 161,247,370 bp
  • A to C, chromosome 2 at 59,878,188 bp
  • A to G, chromosome 2 at 147,373,720 bp
  • A to G, chromosome 2 at 154,524,045 bp
  • T to A, chromosome 3 at 63,362,044 bp
  • T to C, chromosome 3 at 123,343,219 bp
  • T to C, chromosome 4 at 47,383,757 bp
  • T to C, chromosome 4 at 52,825,576 bp
  • T to C, chromosome 4 at 128,509,159 bp
  • C to G, chromosome 4 at 134,155,856 bp
  • A to G, chromosome 4 at 137,405,668 bp
  • T to C, chromosome 5 at 43,773,586 bp
  • C to T, chromosome 5 at 81,741,080 bp
  • T to C, chromosome 5 at 120,887,558 bp
  • T to A, chromosome 5 at 144,025,691 bp
  • T to C, chromosome 6 at 30,439,782 bp
  • C to T, chromosome 6 at 47,963,829 bp
  • T to A, chromosome 6 at 124,627,502 bp
  • T to A, chromosome 6 at 136,635,614 bp
  • T to A, chromosome 6 at 146,590,038 bp
  • T to C, chromosome 7 at 49,458,169 bp
  • T to C, chromosome 7 at 106,677,886 bp
  • T to C, chromosome 7 at 109,460,776 bp
  • T to C, chromosome 8 at 39,632,825 bp
  • A to G, chromosome 8 at 110,978,625 bp
  • T to A, chromosome 9 at 7,384,888 bp
  • A to G, chromosome 9 at 20,171,253 bp
  • T to C, chromosome 9 at 37,711,589 bp
  • A to T, chromosome 9 at 109,724,920 bp
  • A to G, chromosome 11 at 67,284,655 bp
  • C to T, chromosome 11 at 79,940,949 bp
  • T to C, chromosome 11 at 94,238,040 bp
  • T to C, chromosome 12 at 82,420,546 bp
  • A to T, chromosome 12 at 114,896,655 bp
  • T to C, chromosome 13 at 46,646,625 bp
  • T to C, chromosome 13 at 74,356,969 bp
  • A to G, chromosome 17 at 56,877,432 bp
  • C to T, chromosome 18 at 7,268,401 bp
  • A to G, chromosome 19 at 45,818,977 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6842 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044948-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.