Strain Name:
C57BL/6J-MtgxR6853Btlr/Mmmh
Stock Number:
044956-MU
Citation ID:
RRID:MMRRC_044956-MU
Other Names:
R6853 (G1)
Major Collection:

Strain Information

Fga
Name: fibrinogen alpha chain
Synonyms: ENSMUSG00000059807, Fib
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14161
HGNC: HGNC:3661
Homologene: 428
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: Src homology 2 domain-containing inositol-5-phosphatase, SHIP1, s-SHIP, SHIP, SHIP-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Lhx9
Name: LIM homeobox protein 9
Synonyms: 3110009O07Rik, Lhx9 alpha, LH2B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16876
Homologene: 7816
Efr3a
Name: EFR3 homolog A
Synonyms: A130089M23Rik, D030063F01Rik, C920006C10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76740
Homologene: 44222
Lgals9
Name: lectin, galactose binding, soluble 9
Synonyms: gal-9, galectin-9, LGALS35, Lgals5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16859
Homologene: 134662
Pabpc4
Name: poly(A) binding protein, cytoplasmic 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230721
HGNC: HGNC:8557
Homologene: 37855
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: Mll, Mll1, All1, trithorax Drosophila, ALL-1, HTRX1, Cxxc7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Cacul1
Name: CDK2 associated, cullin domain 1
Synonyms: 2810417M16Rik, 9830127L17Rik, 2700078E11Rik, D130033C15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78832
VEGA: 19
Homologene: 17821
Gabpa
Name: GA repeat binding protein, alpha
Synonyms: GABPalpha
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14390
HGNC: HGNC:4071
Homologene: 1543
Ddias
Name: DNA damage-induced apoptosis suppressor
Synonyms: 4632434I11Rik, noxin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74041
Homologene: 51655
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Bcam
Name: basal cell adhesion molecule
Synonyms: B-CAM, Lu, 1200005K12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57278
HGNC: HGNC:6722
Homologene: 21149
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: SPT6, 5131400N11Rik, Supt6h
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20926
Homologene: 40661
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268878
Homologene: 77451
Ctsa
Name: cathepsin A
Synonyms: PPCA, Ppgb
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19025
HGNC: HGNC:9251
Homologene: 80163
Ralbp1
Name: ralA binding protein 1
Synonyms: RLIP76, Rip1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19765
VEGA: 17
HGNC: HGNC:9841
Homologene: 4940
Msh3
Name: mutS homolog 3
Synonyms: Rep3, D13Em1, Rep-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Cntrl
Name: centriolin
Synonyms: 6720467O09Rik, IB3/5, Cep110, Cep1, Ma2a8, b2b1468Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Slc39a6
Name: solute carrier family 39 (metal ion transporter), member 6
Synonyms: Ermelin, Zip6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106957
Homologene: 8199
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Cyp2c70
Name: cytochrome P450, family 2, subfamily c, polypeptide 70
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226105
Homologene: 120027
Sis
Name: sucrase isomaltase
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Kif1a
Name: kinesin family member 1A
Synonyms: Kns1, N-3 kinesin, ATSV, C630002N23Rik, LOC381283
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Sik1
Name: salt inducible kinase 1
Synonyms: Msk, Snf1lk
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17691
VEGA: 17
Homologene: 7847
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Farp2
Name: FERM, RhoGEF and pleckstrin domain protein 2
Synonyms: D030026M03Rik, Fir
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227377
Homologene: 8877
Tnfaip3
Name: tumor necrosis factor, alpha-induced protein 3
Synonyms: A20, zinc finger protein A20, Tnfip3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21929
Homologene: 4582
L3mbtl4
Name: L3MBTL4 histone methyl-lysine binding protein
Synonyms: A730037L19Rik, D930040M24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320858
Homologene: 114383
Mtus2
Name: microtubule associated tumor suppressor candidate 2
Synonyms: A730013O20Rik, C130038G02Rik, 5730592G18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77521
Homologene: 78141
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74362
Homologene: 52601
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224552
Homologene: 115024
Tmf1
Name: TATA element modulatory factor 1
Synonyms: LOC232286, 7030402D04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232286
Homologene: 133801
Or7g32
Name: olfactory receptor family 7 subfamily G member 32
Synonyms: GA_x6K02T2PVTD-13234278-13235216, MOR155-1, Olfr851
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258907
HGNC: HGNC:8466
Homologene: 74178
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Itih-2, Intin2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Stt3a
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Synonyms: Itm1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16430
HGNC: HGNC:6172
Homologene: 40617
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627569
Homologene: 129606
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: Gpd-1, Gpd1, G6pd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Bmp8a
Name: bone morphogenetic protein 8a
Synonyms: Bmp7r1, OP2, osteogenic protein 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12163
Homologene: 135983
Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13097
Homologene: 117948
H2-Q6
Name: histocompatibility 2, Q region locus 6
Synonyms: H-2Q6, Qa6, Qa-6, 0610037M15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110557
Homologene: 128352
Or2h2c
Name: olfactory receptor family 2 subfamily H member 2C
Synonyms: MOR256-29, Olfr92, GA_x6K02T2PSCP-1552066-1551128
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258448
HGNC: HGNC:8253
Homologene: 115562
Slc5a12
Name: solute carrier family 5 (sodium/glucose cotransporter), member 12
Synonyms: SMCT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241612
Homologene: 15107
Oas1a
Name: 2'-5' oligoadenylate synthetase 1A
Synonyms: L3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246730
HGNC: HGNC:8086
Homologene: 1903
Or5b121
Name: olfactory receptor family 5 subfamily B member 121
Synonyms: GA_x6K02T2RE5P-3862389-3863336, MOR202-44, Olfr1480
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 404339
Homologene: 110492
Vamp5
Name: vesicle-associated membrane protein 5
Synonyms: Camp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53620
Homologene: 4833
Thumpd2
Name: THUMP domain containing 2
Synonyms: 2810025A12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72167
VEGA: 17
Homologene: 11898
Or5k15
Name: olfactory receptor family 5 subfamily J member 15
Synonyms: Olfr178, GA_x54KRFPKG5P-55108059-55107100, MOR184-6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258999
Homologene: 79412
Sult2a1
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Synonyms: mSTa1, Std, Sth1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20859
Homologene: 37741
Htra2
Name: HtrA serine peptidase 2
Synonyms: Prss25, mnd2, HtrA2, OMI
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64704
Homologene: 113300
6030458C11Rik
Name: RIKEN cDNA 6030458C11 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77877
VEGA: 15
Homologene: 10149
Gm21798
Name: predicted gene, 21798
Type: Gene
Species: Mouse
Chromosome: 15
Zfp658
Name: zinc finger protein 658
Synonyms: Gm7145
Type: Gene
Species: Mouse
Chromosome: 1
Homologene: 88945
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 87,681,680 bp
  • T to G, chromosome 1 at 93,039,802 bp
  • T to C, chromosome 1 at 93,570,016 bp
  • A to C, chromosome 1 at 117,986,144 bp
  • ACC to ACCC, chromosome 1 at 138,841,806 bp
  • T to G, chromosome 1 at 188,911,237 bp
  • T to C, chromosome 2 at 10,115,266 bp
  • T to A, chromosome 2 at 35,129,821 bp
  • T to C, chromosome 2 at 101,642,221 bp
  • C to T, chromosome 2 at 104,241,155 bp
  • A to G, chromosome 2 at 110,624,194 bp
  • T to A, chromosome 2 at 164,837,364 bp
  • A to G, chromosome 3 at 72,891,426 bp
  • A to G, chromosome 3 at 83,030,912 bp
  • T to C, chromosome 3 at 100,013,235 bp
  • T to C, chromosome 4 at 123,294,743 bp
  • C to A, chromosome 4 at 123,342,683 bp
  • T to C, chromosome 4 at 149,982,462 bp
  • T to C, chromosome 5 at 30,388,239 bp
  • A to T, chromosome 5 at 109,092,905 bp
  • T to A, chromosome 5 at 120,907,428 bp
  • A to G, chromosome 5 at 148,107,011 bp
  • G to A, chromosome 6 at 72,380,441 bp
  • A to G, chromosome 6 at 83,053,831 bp
  • T to G, chromosome 6 at 97,168,849 bp
  • CAAAGTAA to CAAAGTAAAGTAA, chromosome 6 at 113,399,157 bp
  • C to T, chromosome 7 at 13,801,487 bp
  • T to C, chromosome 7 at 19,760,406 bp
  • T to C, chromosome 7 at 25,518,136 bp
  • C to T, chromosome 7 at 92,859,565 bp
  • G to A, chromosome 7 at 96,837,295 bp
  • G to A, chromosome 7 at 105,703,728 bp
  • T to G, chromosome 9 at 19,496,806 bp
  • G to A, chromosome 9 at 36,741,727 bp
  • G to A, chromosome 9 at 44,818,407 bp
  • A to G, chromosome 10 at 19,003,751 bp
  • T to C, chromosome 10 at 81,075,661 bp
  • T to C, chromosome 11 at 78,232,830 bp
  • A to T, chromosome 11 at 78,966,006 bp
  • A to G, chromosome 11 at 113,780,929 bp
  • T to G, chromosome 13 at 70,603,302 bp
  • A to G, chromosome 13 at 92,312,572 bp
  • G to T, chromosome 15 at 12,817,945 bp
  • A to T, chromosome 15 at 64,817,865 bp
  • A to T, chromosome 15 at 64,817,867 bp
  • G to A, chromosome 15 at 65,829,830 bp
  • A to G, chromosome 16 at 29,321,662 bp
  • C to T, chromosome 16 at 58,889,758 bp
  • T to A, chromosome 16 at 58,889,759 bp
  • T to A, chromosome 16 at 84,860,499 bp
  • A to T, chromosome 17 at 19,065,801 bp
  • A to T, chromosome 17 at 31,854,206 bp
  • T to C, chromosome 17 at 35,428,359 bp
  • G to A, chromosome 17 at 37,111,508 bp
  • C to T, chromosome 17 at 65,852,756 bp
  • G to A, chromosome 17 at 68,777,920 bp
  • A to T, chromosome 17 at 71,436,743 bp
  • C to A, chromosome 17 at 81,065,030 bp
  • A to T, chromosome 18 at 22,109,876 bp
  • A to G, chromosome 18 at 24,599,319 bp
  • T to A, chromosome 19 at 13,529,931 bp
  • T to A, chromosome 19 at 39,438,304 bp
  • C to T, chromosome 19 at 40,183,920 bp
  • A to T, chromosome 19 at 60,529,466 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6853 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044956-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.