Strain Name:
C57BL/6J-MtgxR6857Btlr/Mmmh
Stock Number:
044959-MU
Citation ID:
RRID:MMRRC_044959-MU
Other Names:
R6857 (G1)
Major Collection:

Strain Information

Tagln3
Name: transgelin 3
Synonyms: 2700038H05Rik, Np25, 2900005O10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56370
Homologene: 22337
Plxnd1
Name: plexin D1
Synonyms: b2b553Clo, 6230425C21Rik, b2b1863Clo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Nek7
Name: NIMA (never in mitosis gene a)-related expressed kinase 7
Synonyms: 2810460C19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59125
Homologene: 69340
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
Mtmr12
Name: myotubularin related protein 12
Synonyms: Pip3ap, C730015A02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268783
Homologene: 10403
Tcf3
Name: transcription factor 3
Synonyms: Pan1, bHLHb21, A1, Pan2, E2A, ALF2, E12, E47, Tcfe2a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21423
Homologene: 2408
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66691
Homologene: 32637
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 3526402J09Rik, 5730590C14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77097
Homologene: 64680
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, Swl, Dnec1, Loa, dynein heavy chain, retrograde transport, 9930018I23Rik, Dnchc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Zswim7
Name: zinc finger SWIM-type containing 7
Synonyms: 2410012H22Rik, SWS1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69747
Homologene: 15565
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, Zubr1, D930005K06Rik, 1810009A16Rik, p600
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Mxra8
Name: matrix-remodelling associated 8
Synonyms: 1200013A08Rik, Asp3, DICAM, limitrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74761
HGNC: HGNC:7542
Homologene: 11500
Copg2
Name: coatomer protein complex, subunit gamma 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54160
HGNC: HGNC:2237
Homologene: 56292
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68187
Homologene: 32665
Zfp998
Name: zinc finger protein 998
Synonyms: 2410141K09Rik, Gt(pU21)35Imeg, Gt(Ayu21)35Imeg, Snerv1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76803
Homologene: 136362
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546144
Homologene: 52326
Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms: Tak1 binding protein 2, 1110030N06Rik, A530078N03Rik, Map3k7ip2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68652
Homologene: 9019
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Or8b50
Name: olfactory receptor family 8 subfamily B member 50
Synonyms: GA_x6K02T2PVTD-32308823-32309773, Olfr914, MOR165-7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258782
VEGA: 9
Homologene: 115511
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Itpr5, Ip3r2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Ahnak
Name: AHNAK nucleoprotein
Synonyms: 2310047C17Rik, DY6, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Ugt2b37
Name: UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms: 0610033E06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 112417
Homologene: 137225
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MHC2B, MyHC-IIb, Minmus, Minimsc, Myhsf, MYH-2B, MM
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Serpina3m
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3M
Synonyms: alpha-1 antiproteinase, Spi2-rs1, MMSPi2.4, Spi2.4, contrapsin-like, MMCM7, 3e46, Spi-2l, antitrypsin, Spi-2rs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20717
HGNC: HGNC:16
Homologene: 111129
Lao1
Name: L-amino acid oxidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100470
Homologene: 44223
Prdm9
Name: PR domain containing 9
Synonyms: G1-419-29, repro7, Rcr1, Meisetz, Dsbc1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213389
Homologene: 104139
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: UNC45, D230041A13Rik, Cmya4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217012
Homologene: 14666
Kctd8
Name: potassium channel tetramerisation domain containing 8
Synonyms: A730087N02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243043
Homologene: 18464
Zfp1004
Name: zinc finger protein 1004
Synonyms: Gm14139
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100271882
Homologene: 134546
Hdac9
Name: histone deacetylase 9
Synonyms: HDRP, Mitr, Hdac7b, D030072B18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 79221
Homologene: 128578
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Pygm
Name: muscle glycogen phosphorylase
Synonyms: PG
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19309
HGNC: HGNC:9726
Homologene: 2145
Plekha8
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Synonyms: FAPP2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231999
Homologene: 32284
Ky
Name: kyphoscoliosis peptidase
Synonyms: D9Mgc44e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16716
Homologene: 11506
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627814
Homologene: 129678
Tmem14a
Name: transmembrane protein 14A
Synonyms: PTD011, 5730496E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75712
Homologene: 36341
Epx
Name: eosinophil peroxidase
Synonyms: EPO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13861
HGNC: HGNC:3423
Homologene: 20144
Clvs1
Name: clavesin 1
Synonyms: 4933402J24Rik, Rlbp1l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74438
Homologene: 65267
Or8k35
Name: olfactory receptor family 8 subfamily K member 35
Synonyms: Olfr1082, MOR192-4_p, GA_x6K02T2Q125-48079993-48079157
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404473
Homologene: 104285
Cd38
Name: CD38 antigen
Synonyms: Cd38-rs1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12494
HGNC: HGNC:1667
Homologene: 1345
Paqr5
Name: progestin and adipoQ receptor family member V
Synonyms: 0610010I15Rik, mPRg
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74090
Homologene: 9788
Or5w17
Name: olfactory receptor family 5 subfamily W member 17
Synonyms: MOR177-10, Olfr1141, GA_x6K02T2Q125-49257818-49256883
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258630
Homologene: 74080
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11498
Homologene: 86950
Plpbp
Name: pyridoxal phosphate binding protein
Synonyms: Prosc, 2200002F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114863
HGNC: HGNC:9457
Homologene: 5211
Hax1
Name: HCLS1 associated X-1
Synonyms: mHAX-1s, Hs1bp1, HS1-associated protein X-1, Silg111, HAX-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23897
Homologene: 4463
Vmn1r88
Name: vomeronasal 1 receptor, 88
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312474
Homologene: 74345
Best2
Name: bestrophin 2
Synonyms: Vmd2l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212989
Homologene: 41187
Cd3d
Name: CD3 antigen, delta polypeptide
Synonyms: T3d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12500
VEGA: 9
HGNC: HGNC:1673
Homologene: 585
B020011L13Rik
Name: RIKEN cDNA B020011L13 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 547097
Homologene: 140625
Cc2d2b
Name: coiled-coil and C2 domain containing 2B
Synonyms: EG668310
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 668310
Homologene: 141114
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 21,229,545 bp
  • G to C, chromosome 1 at 24,014,789 bp
  • A to T, chromosome 1 at 117,801,288 bp
  • C to T, chromosome 1 at 138,515,682 bp
  • A to G, chromosome 2 at 34,728,377 bp
  • T to A, chromosome 2 at 76,917,931 bp
  • A to T, chromosome 2 at 86,594,264 bp
  • A to T, chromosome 2 at 87,753,487 bp
  • G to T, chromosome 2 at 150,192,062 bp
  • T to G, chromosome 3 at 89,997,452 bp
  • T to A, chromosome 3 at 127,581,447 bp
  • A to G, chromosome 4 at 9,449,433 bp
  • T to A, chromosome 4 at 58,814,065 bp
  • C to A, chromosome 4 at 70,245,396 bp
  • T to C, chromosome 4 at 118,963,826 bp
  • G to A, chromosome 4 at 139,486,051 bp
  • A to G, chromosome 4 at 155,843,136 bp
  • A to T, chromosome 5 at 35,030,022 bp
  • T to A, chromosome 5 at 43,906,198 bp
  • T to C, chromosome 5 at 69,296,702 bp
  • C to G, chromosome 5 at 87,240,846 bp
  • G to T, chromosome 6 at 30,863,598 bp
  • T to C, chromosome 6 at 54,629,935 bp
  • G to T, chromosome 6 at 115,993,763 bp
  • C to A, chromosome 6 at 146,397,019 bp
  • A to T, chromosome 7 at 13,178,331 bp
  • A to G, chromosome 8 at 27,045,426 bp
  • C to A, chromosome 8 at 62,061,017 bp
  • A to G, chromosome 8 at 85,007,823 bp
  • T to C, chromosome 9 at 38,607,011 bp
  • T to G, chromosome 9 at 44,985,604 bp
  • G to T, chromosome 9 at 61,976,088 bp
  • G to T, chromosome 9 at 74,155,041 bp
  • G to A, chromosome 9 at 102,542,432 bp
  • T to C, chromosome 10 at 7,920,413 bp
  • T to C, chromosome 10 at 80,416,899 bp
  • A to T, chromosome 11 at 62,281,129 bp
  • T to C, chromosome 11 at 67,249,885 bp
  • A to G, chromosome 11 at 82,913,212 bp
  • T to A, chromosome 11 at 87,869,955 bp
  • A to G, chromosome 11 at 105,910,288 bp
  • A to G, chromosome 11 at 110,219,688 bp
  • T to G, chromosome 12 at 34,393,363 bp
  • T to C, chromosome 12 at 81,419,949 bp
  • T to C, chromosome 12 at 104,389,326 bp
  • T to C, chromosome 12 at 110,658,547 bp
  • A to T, chromosome 13 at 66,432,102 bp
  • A to T, chromosome 13 at 113,319,958 bp
  • T to A, chromosome 15 at 12,263,832 bp
  • T to C, chromosome 15 at 102,223,465 bp
  • G to T, chromosome 16 at 45,724,236 bp
  • T to A, chromosome 17 at 7,772,170 bp
  • T to C, chromosome 17 at 15,544,256 bp
  • C to T, chromosome 17 at 20,540,670 bp
  • A to T, chromosome 18 at 49,864,835 bp
  • G to T, chromosome 19 at 6,393,757 bp
  • C to T, chromosome 19 at 9,037,168 bp
  • T to C, chromosome 19 at 40,770,865 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6857 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044959-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.