Strain Name:
C57BL/6J-MtgxR6877Btlr/Mmmh
Stock Number:
044973-MU
Citation ID:
RRID:MMRRC_044973-MU
Other Names:
R6877 (G1)
Major Collection:

Strain Information

Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: StIP1, Stat3-interacting protein, Statip1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58523
VEGA: 18
Homologene: 6019
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd, Edd1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Esco2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms: D030072L07Rik, 2410004I17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71988
Homologene: 12432
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: Spna-2, 2610027H02Rik, alphaII-spectrin, alpha-fodrin, Spna2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100763
Homologene: 8783
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Pcnt
Name: pericentrin (kendrin)
Synonyms: m239Asp, m275Asp, Pcnt2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18541
VEGA: 10
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lphn2, Lec1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Zfp516
Name: zinc finger protein 516
Synonyms: C330029B10Rik, Zfp26l
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Kcnk5
Name: potassium channel, subfamily K, member 5
Synonyms: TASK-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16529
VEGA: 14
HGNC: HGNC:6280
Homologene: 2773
Bcl7a
Name: B cell CLL/lymphoma 7A
Synonyms: 4432415N06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77045
HGNC: HGNC:1004
Homologene: 10869
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: 5430414H02Rik, E330005K07Rik, peroxisome biogenesis factor 1, ZWS1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Aqr
Name: aquarius
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11834
Homologene: 7629
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 404710
Homologene: 26400
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Arhgef17
Name: Rho guanine nucleotide exchange factor 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207212
Homologene: 129601
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: CI-MPR, IGF-II/CI-MPR, Mpr300, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Prkrip1
Name: Prkr interacting protein 1 (IL11 inducible)
Synonyms: C114, 8430424D23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66801
Homologene: 6323
Btbd10
Name: BTB domain containing 10
Synonyms: Gmrp1, 1110056N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68815
Homologene: 13009
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 2700048G21Rik, CCCAP, 5730470G24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76816
Homologene: 4839
Tsc22d4
Name: Tsc22 domain family, member 4
Synonyms: Thg-1pit, 1700023B23Rik, Spacdr, 0610009M14Rik, Tsc22d4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78829
Homologene: 11390
AU041133
Name: expressed sequence AU041133
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216177
Homologene: 87560
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: A030003E17Rik, IF2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226982
Homologene: 134613
Zic5
Name: zinc finger protein of the cerebellum 5
Synonyms: odd-paired related, 1700049L20Rik, Opr
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65100
Homologene: 11301
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Pcdhb4
Name: protocadherin beta 4
Synonyms: Pcdhb5A, PcdhbD
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93875
HGNC: HGNC:8690
Homologene: 62176
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC382129, LOC234973, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, Dnahc14, A230079K17Rik, LOC381311
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Vwf
Name: Von Willebrand factor
Synonyms: 6820430P06Rik, B130011O06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Zc3h12d
Name: zinc finger CCCH type containing 12D
Synonyms: TFL, D730019B10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237256
VEGA: 10
Homologene: 18225
Stx2
Name: syntaxin 2
Synonyms: G1-536-1, Syn-2, Epim, repro34
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13852
HGNC: HGNC:3403
Homologene: 37559
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Nol4
Name: nucleolar protein 4
Synonyms: 1700013J13Rik, 4930568N03Rik, LOC383304
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Sumf2
Name: sulfatase modifying factor 2
Synonyms: 2610040F05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67902
Homologene: 41037
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627111
Homologene: 115024
Clcnkb
Name: chloride channel, voltage-sensitive Kb
Synonyms: Clck2, ClC-K2, Clcnk1l, Clcnk2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56365
Homologene: 107317
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: Veph, 2810471M23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72789
Homologene: 11624
Zpld1
Name: zona pellucida like domain containing 1
Synonyms: 9430016A21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239852
Homologene: 18401
Vmn1r82
Name: vomeronasal 1 receptor 82
Synonyms: V1rg12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171268
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244199
Homologene: 18255
Dyrk2
Name: dual-specificity tyrosine phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Rnf133
Name: ring finger protein 133
Synonyms: Greul2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 386611
Homologene: 44549
Or4f14b
Name: olfactory receptor family 4 subfamily F member 14B
Synonyms: MOR245-19P, Olfr1307, GA_x6K02T2Q125-72988111-72987173
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257956
Homologene: 128383
Dcst1
Name: DC-STAMP domain containing 1
Synonyms: A330106H01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77772
Homologene: 14981
Or10g3b
Name: olfactory receptor family 10 subfamily G member 3B
Synonyms: Olfr1513, GA_x6K02T2RJGY-644134-645075, MOR223-10, MOR223-7P
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258008
HGNC: HGNC:8171
Homologene: 79404
Ntaq1
Name: N-terminal glutamine amidase 1
Synonyms: Wdyhv1, 2410187C16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76773
VEGA: 15
Homologene: 9968
Spi1
Name: Spi-1 proto-oncogene
Synonyms: PU.1, Tcfpu1, Dis-1, Sfpi1, Spi-1, spleen focus forming virus (SFFV) proviral integration oncogene, Sfpi-1, Tfpu.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20375
Homologene: 2346
Litafd
Name: LITAF domain containing
Synonyms: Gm43786, Gm5767
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 436336
Homologene: 80030
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 38,050,239 bp
  • G to A, chromosome 1 at 177,011,935 bp
  • C to A, chromosome 1 at 181,628,432 bp
  • C to G, chromosome 2 at 30,030,973 bp
  • T to C, chromosome 2 at 91,114,396 bp
  • T to C, chromosome 2 at 111,944,839 bp
  • A to T, chromosome 2 at 114,116,571 bp
  • T to C, chromosome 3 at 66,255,084 bp
  • GGAGAG to GGAG, chromosome 3 at 88,112,771 bp
  • T to C, chromosome 3 at 89,350,360 bp
  • T to C, chromosome 3 at 148,817,286 bp
  • T to C, chromosome 4 at 141,404,832 bp
  • A to T, chromosome 5 at 3,635,505 bp
  • G to T, chromosome 5 at 29,587,318 bp
  • A to G, chromosome 5 at 123,351,895 bp
  • A to G, chromosome 5 at 128,987,820 bp
  • G to A, chromosome 5 at 129,850,026 bp
  • A to T, chromosome 5 at 136,189,624 bp
  • A to G, chromosome 5 at 137,762,593 bp
  • A to G, chromosome 6 at 23,649,487 bp
  • T to A, chromosome 6 at 125,657,201 bp
  • T to C, chromosome 7 at 12,305,363 bp
  • A to G, chromosome 7 at 100,881,341 bp
  • G to A, chromosome 7 at 107,790,108 bp
  • A to T, chromosome 7 at 113,322,760 bp
  • C to T, chromosome 7 at 141,809,744 bp
  • T to C, chromosome 8 at 43,625,237 bp
  • A to C, chromosome 9 at 15,999,268 bp
  • T to C, chromosome 9 at 119,609,782 bp
  • G to T, chromosome 10 at 7,839,971 bp
  • A to C, chromosome 10 at 76,434,017 bp
  • A to G, chromosome 10 at 82,151,571 bp
  • A to T, chromosome 10 at 118,860,423 bp
  • G to A, chromosome 11 at 120,873,702 bp
  • A to G, chromosome 12 at 59,068,767 bp
  • T to C, chromosome 14 at 20,144,716 bp
  • T to A, chromosome 14 at 52,349,813 bp
  • A to G, chromosome 14 at 65,831,045 bp
  • G to A, chromosome 14 at 122,459,688 bp
  • A to G, chromosome 15 at 38,002,570 bp
  • C to A, chromosome 15 at 58,153,678 bp
  • G to A, chromosome 16 at 8,683,309 bp
  • A to G, chromosome 16 at 20,179,594 bp
  • C to T, chromosome 16 at 55,251,671 bp
  • A to G, chromosome 17 at 12,697,341 bp
  • A to G, chromosome 17 at 18,168,822 bp
  • G to T, chromosome 17 at 30,746,959 bp
  • A to T, chromosome 18 at 22,719,129 bp
  • T to A, chromosome 18 at 24,634,976 bp
  • A to G, chromosome 18 at 37,309,572 bp
  • T to C, chromosome 18 at 82,955,791 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6877 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044973-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.