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Strain Name:
C57BL/6J-MtgxR6877Btlr/Mmmh
Stock Number:
044973-MU
Citation ID:
RRID:MMRRC_044973-MU
Other Names:
R6877 (G1)
Major Collection:

Strain Information

Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: Stat3-interacting protein, StIP1, Statip1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58523
VEGA: 18
Homologene: 6019
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Esco2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms: D030072L07Rik, 2410004I17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71988
Homologene: 12432
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna-2, 2610027H02Rik, Spna2, alphaII-spectrin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100763
Homologene: 8783
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 38,050,239 bp
  • G to A, chromosome 1 at 177,011,935 bp
  • C to A, chromosome 1 at 181,628,432 bp
  • C to G, chromosome 2 at 30,030,973 bp
  • T to C, chromosome 2 at 91,114,396 bp
  • T to C, chromosome 2 at 111,944,839 bp
  • A to T, chromosome 2 at 114,116,571 bp
  • T to C, chromosome 3 at 66,255,084 bp
  • GGAGAG to GGAG, chromosome 3 at 88,112,771 bp
  • T to C, chromosome 3 at 89,350,360 bp
  • T to C, chromosome 3 at 148,817,286 bp
  • T to C, chromosome 4 at 141,404,832 bp
  • A to T, chromosome 5 at 3,635,505 bp
  • G to T, chromosome 5 at 29,587,318 bp
  • A to G, chromosome 5 at 123,351,895 bp
  • A to G, chromosome 5 at 128,987,820 bp
  • G to A, chromosome 5 at 129,850,026 bp
  • A to T, chromosome 5 at 136,189,624 bp
  • A to G, chromosome 5 at 137,762,593 bp
  • A to G, chromosome 6 at 23,649,487 bp
  • T to A, chromosome 6 at 125,657,201 bp
  • T to C, chromosome 7 at 12,305,363 bp
  • A to G, chromosome 7 at 100,881,341 bp
  • G to A, chromosome 7 at 107,790,108 bp
  • A to T, chromosome 7 at 113,322,760 bp
  • C to T, chromosome 7 at 141,809,744 bp
  • T to C, chromosome 8 at 43,625,237 bp
  • A to C, chromosome 9 at 15,999,268 bp
  • T to C, chromosome 9 at 119,609,782 bp
  • G to T, chromosome 10 at 7,839,971 bp
  • A to C, chromosome 10 at 76,434,017 bp
  • A to G, chromosome 10 at 82,151,571 bp
  • A to T, chromosome 10 at 118,860,423 bp
  • G to A, chromosome 11 at 120,873,702 bp
  • A to G, chromosome 12 at 59,068,767 bp
  • T to C, chromosome 14 at 20,144,716 bp
  • T to A, chromosome 14 at 52,349,813 bp
  • A to G, chromosome 14 at 65,831,045 bp
  • G to A, chromosome 14 at 122,459,688 bp
  • A to G, chromosome 15 at 38,002,570 bp
  • C to A, chromosome 15 at 58,153,678 bp
  • G to A, chromosome 16 at 8,683,309 bp
  • A to G, chromosome 16 at 20,179,594 bp
  • C to T, chromosome 16 at 55,251,671 bp
  • A to G, chromosome 17 at 12,697,341 bp
  • A to G, chromosome 17 at 18,168,822 bp
  • G to T, chromosome 17 at 30,746,959 bp
  • A to T, chromosome 18 at 22,719,129 bp
  • T to A, chromosome 18 at 24,634,976 bp
  • A to G, chromosome 18 at 37,309,572 bp
  • T to C, chromosome 18 at 82,955,791 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6877 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044973-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.