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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR6880Btlr/Mmmh
Stock Number:
044976-MU
Citation ID:
RRID:MMRRC_044976-MU
Other Names:
R6880 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Qki
Name: quaking, KH domain containing RNA binding
Synonyms: l(17)-1Wis, QkI, l17Wis1, 1110003F05Rik, Qk
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19317
VEGA: 17
Homologene: 11059

Additional Resources
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Gene Ontology
BioGPS
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KOMP Phenotyping
Monarch
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ClinGen
Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Gid4
Name: GID complex subunit 4, VID24 homolog
Synonyms: 4933439F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66771
Homologene: 5971

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Rxra
Name: retinoid X receptor alpha
Synonyms: RXRalpha1, RXR alpha 1, 9530071D11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20181
Homologene: 2220

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 11,132,384 bp
  • T to C, chromosome 1 at 12,842,755 bp
  • T to C, chromosome 1 at 38,535,162 bp
  • T to C, chromosome 1 at 38,627,128 bp
  • T to C, chromosome 1 at 46,527,671 bp
  • A to G, chromosome 1 at 83,257,257 bp
  • A to G, chromosome 1 at 131,804,101 bp
  • T to A, chromosome 1 at 149,851,451 bp
  • T to C, chromosome 1 at 162,657,033 bp
  • G to A, chromosome 2 at 27,748,656 bp
  • G to T, chromosome 2 at 31,343,056 bp
  • T to A, chromosome 2 at 59,912,939 bp
  • T to C, chromosome 2 at 76,720,498 bp
  • A to G, chromosome 2 at 86,483,725 bp
  • A to G, chromosome 2 at 132,872,112 bp
  • T to C, chromosome 2 at 167,105,807 bp
  • T to A, chromosome 3 at 36,069,705 bp
  • T to A, chromosome 3 at 53,477,839 bp
  • A to G, chromosome 3 at 54,738,843 bp
  • A to G, chromosome 3 at 86,547,156 bp
  • A to G, chromosome 4 at 14,516,159 bp
  • A to T, chromosome 4 at 62,336,495 bp
  • A to T, chromosome 5 at 32,830,867 bp
  • T to C, chromosome 5 at 37,105,623 bp
  • T to C, chromosome 5 at 65,277,386 bp
  • C to A, chromosome 5 at 120,901,940 bp
  • A to T, chromosome 5 at 144,191,633 bp
  • A to G, chromosome 6 at 85,348,845 bp
  • A to G, chromosome 6 at 136,561,040 bp
  • A to G, chromosome 7 at 5,030,549 bp
  • T to C, chromosome 7 at 55,933,251 bp
  • A to G, chromosome 7 at 89,510,825 bp
  • A to T, chromosome 7 at 106,805,812 bp
  • T to C, chromosome 7 at 144,644,742 bp
  • C to T, chromosome 9 at 64,177,053 bp
  • T to A, chromosome 9 at 80,404,800 bp
  • G to A, chromosome 10 at 99,126,084 bp
  • T to C, chromosome 11 at 5,628,748 bp
  • C to T, chromosome 11 at 34,688,452 bp
  • T to A, chromosome 11 at 60,436,435 bp
  • T to A, chromosome 11 at 80,002,172 bp
  • T to C, chromosome 12 at 113,307,106 bp
  • T to C, chromosome 12 at 114,773,043 bp
  • T to C, chromosome 13 at 34,894,453 bp
  • T to C, chromosome 13 at 78,025,494 bp
  • T to A, chromosome 13 at 89,712,381 bp
  • A to C, chromosome 13 at 98,354,717 bp
  • C to A, chromosome 14 at 70,440,015 bp
  • T to G, chromosome 15 at 25,971,739 bp
  • T to C, chromosome 15 at 59,350,172 bp
  • T to C, chromosome 15 at 76,602,539 bp
  • T to C, chromosome 16 at 93,690,538 bp
  • T to C, chromosome 16 at 97,997,427 bp
  • T to C, chromosome 17 at 10,215,447 bp
  • A to T, chromosome 17 at 18,914,508 bp
  • A to G, chromosome 17 at 25,934,828 bp
  • A to T, chromosome 17 at 57,509,187 bp
  • C to T, chromosome 17 at 75,321,049 bp
  • T to A, chromosome 18 at 20,088,372 bp
  • A to G, chromosome 18 at 52,869,064 bp
  • A to T, chromosome 18 at 74,722,430 bp
  • A to G, chromosome 19 at 12,268,610 bp
  • G to C, chromosome 19 at 40,376,800 bp
  • A to G, chromosome 19 at 45,007,416 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6880 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
044976-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.