Strain Name:
C57BL/6J-MtgxR6892Btlr/Mmmh
Stock Number:
044986-MU
Citation ID:
RRID:MMRRC_044986-MU
Other Names:
R6892 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: spectrin G, Spnb-2, non-erythrocytic, brain spectrin, Spnb2, elf1, elf3, 9930031C03Rik, beta fodrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Cdk18
Name: cyclin dependent kinase 18
Synonyms: Pctk3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18557
HGNC: HGNC:8751
Homologene: 1949
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4921507G06Rik, 4930435C18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Ano6
Name: anoctamin 6
Synonyms: F730003B03Rik, Tmem16f, 2900059G15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68510
Homologene: 53111
Bltp3b
Name: bridge-like lipid transfer protein family member 3B
Synonyms: 4930506D01Rik, E030041M21Rik, Uhrf1bp1l, 2010319N22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75089
VEGA: 10
Homologene: 12590
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Synonyms: C3G, 4932418O06Rik, Grf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107746
HGNC: HGNC:4568
Homologene: 50501
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: RPA194, Rpo1-4, mRPA1, 194kDa, 2900087K15Rik, 3010014K16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20019
Homologene: 7033
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, dynein heavy chain, retrograde transport, Dnchc1, Swl, MAP1C, 9930018I23Rik, Dnec1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14055
HGNC: HGNC:3526
Homologene: 20458
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
Synonyms: Rock-I, 1110055K06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19877
VEGA: 18
Homologene: 55899
Iws1
Name: IWS1, SUPT6 interacting protein
Synonyms: 1700069O15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 73473
Homologene: 134421
Gm14403
Name: predicted gene 14403
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433520
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: L-CPT I, CPTI, Cpt1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Dcdc2a
Name: doublecortin domain containing 2a
Synonyms: Dcdc2, RU2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195208
Homologene: 9483
Peg3
Name: paternally expressed 3
Synonyms: Zfp102, End4, Gcap4, Pw1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Fzd3
Name: frizzled class receptor 3
Synonyms: D930050A07Rik, Fz3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14365
HGNC: HGNC:4041
Homologene: 23004
Cpa4
Name: carboxypeptidase A4
Synonyms: 1110019K20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71791
Homologene: 56753
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, ENSMUSG00000043296, E130209G04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
4930442H23Rik
Name: RIKEN cDNA 4930442H23 gene
Type: Gene
Species: Mouse
Chromosome: 10
Syk
Name: spleen tyrosine kinase
Synonyms: Sykb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20963
Homologene: 2390
Sppl2a
Name: signal peptide peptidase like 2A
Synonyms: 2010106G01Rik, C130089K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66552
Homologene: 36411
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, Nesp2g, diminished cone electroretinogram
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244484
Homologene: 12460
Cdt1
Name: chromatin licensing and DNA replication factor 1
Synonyms: Ris2, 2610318F11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67177
Homologene: 32650
Gm17067
Name: predicted gene 17067
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 115486519
Nhsl1
Name: NHS like 1
Synonyms: D10Bwg0940e, A630035H13Rik, 5730409E15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215819
Homologene: 27834
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: T2dm1, insulin level locus 1, A830015P08Rik, LLGL4, t2md1, tomosyn-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207227
Homologene: 18173
Or10a49
Name: olfactory receptor family 10 subfamily A member 49
Synonyms: GA_x6K02T2PBJ9-11199311-11198367, Olfr517, MOR268-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258136
Homologene: 79413
Tarm1
Name: T cell-interacting, activating receptor on myeloid cells 1
Synonyms: Gm9904, 9930022N03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245126
Homologene: 120241
Ift140
Name: intraflagellar transport 140
Synonyms: Tce5, Wdtc2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106633
Homologene: 40979
Zfp454
Name: zinc finger protein 454
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237758
Homologene: 72226
Tor1aip2
Name: torsin A interacting protein 2
Synonyms: LULL1, 1110020D10Rik, Ifrg15, 15kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240832
Homologene: 17028
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: Rgsl2, 4930415K13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240816
Homologene: 129962
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Capn5
Name: calpain 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12337
HGNC: HGNC:1482
Homologene: 31212
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19731
Homologene: 9039
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: NSS2, SNS2, NaT, NaN
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Cab39
Name: calcium binding protein 39
Synonyms: MO25alpha, 39kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12283
Homologene: 69212
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Grep1
Name: glycine rich extracellular protein 1
Synonyms: 1520401A03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320309
Cyp3a11
Name: cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms: Pcn, Cyp3a, IIIAm1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13112
HGNC: HGNC:2638
Homologene: 133568
Pgm1
Name: phosphoglucomutase 1
Synonyms: Pgm-2, Pgm1a, 2610020G18Rik, Pgm2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72157
HGNC: HGNC:8905
Homologene: 1979
Tcte1
Name: t-complex-associated testis expressed 1
Synonyms: D17Sil1, Tcte-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21645
VEGA: 17
Homologene: 8434
A930002H24Rik
Name: RIKEN cDNA A930002H24 gene
Type: Gene
Species: Mouse
Chromosome: 17
Sgms2
Name: sphingomyelin synthase 2
Synonyms: 4933405A16Rik, 5133401H06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74442
Homologene: 32705
4933421I07Rik
Name: RIKEN cDNA 4933421I07 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71162
Homologene: 86127
Tbc1d22b
Name: TBC1 domain family, member 22B
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381085
Homologene: 23043
Vmn1r41
Name: vomeronasal 1 receptor 41
Synonyms: V1rb9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113857
Homologene: 113975
Gm38119
Name: predicted gene, 38119
Type: Gene
Species: Mouse
Chromosome: 3
Mptx1
Name: mucosal pentraxin 1
Synonyms: 1810030J14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66289
Homologene: 134535
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 20,523,515 bp
  • A to G, chromosome 1 at 54,415,941 bp
  • A to G, chromosome 1 at 85,848,377 bp
  • G to T, chromosome 1 at 132,122,110 bp
  • A to T, chromosome 1 at 152,539,940 bp
  • G to T, chromosome 1 at 153,821,499 bp
  • A to T, chromosome 1 at 156,065,181 bp
  • A to G, chromosome 1 at 174,332,265 bp
  • T to C, chromosome 2 at 29,699,840 bp
  • T to A, chromosome 2 at 48,897,075 bp
  • T to A, chromosome 2 at 126,343,002 bp
  • A to G, chromosome 2 at 126,913,575 bp
  • T to G, chromosome 2 at 177,509,247 bp
  • A to G, chromosome 3 at 92,738,222 bp
  • A to G, chromosome 3 at 131,342,154 bp
  • A to G, chromosome 4 at 99,929,708 bp
  • A to T, chromosome 5 at 139,767,828 bp
  • A to T, chromosome 5 at 142,046,298 bp
  • G to A, chromosome 5 at 145,860,448 bp
  • G to T, chromosome 6 at 30,583,629 bp
  • A to T, chromosome 6 at 71,964,712 bp
  • C to A, chromosome 6 at 89,747,181 bp
  • T to C, chromosome 7 at 3,497,490 bp
  • C to T, chromosome 7 at 6,708,899 bp
  • T to C, chromosome 7 at 42,446,407 bp
  • A to C, chromosome 7 at 42,710,675 bp
  • A to T, chromosome 7 at 98,135,941 bp
  • A to G, chromosome 7 at 108,868,515 bp
  • T to C, chromosome 8 at 54,673,596 bp
  • T to A, chromosome 8 at 122,570,212 bp
  • G to A, chromosome 9 at 45,683,830 bp
  • T to A, chromosome 9 at 88,844,924 bp
  • T to A, chromosome 9 at 119,806,969 bp
  • C to T, chromosome 10 at 18,524,343 bp
  • C to A, chromosome 10 at 81,183,144 bp
  • G to A, chromosome 10 at 89,805,123 bp
  • T to C, chromosome 10 at 107,576,004 bp
  • A to G, chromosome 11 at 30,142,187 bp
  • A to G, chromosome 11 at 50,873,198 bp
  • A to T, chromosome 11 at 101,199,361 bp
  • T to A, chromosome 12 at 75,962,528 bp
  • G to A, chromosome 12 at 110,638,901 bp
  • A to G, chromosome 13 at 25,056,460 bp
  • A to T, chromosome 13 at 52,632,898 bp
  • G to C, chromosome 14 at 65,209,881 bp
  • T to C, chromosome 15 at 95,967,624 bp
  • A to T, chromosome 16 at 37,188,629 bp
  • A to G, chromosome 17 at 23,712,354 bp
  • A to G, chromosome 17 at 25,020,546 bp
  • A to G, chromosome 17 at 29,595,890 bp
  • A to G, chromosome 17 at 45,533,157 bp
  • T to G, chromosome 17 at 46,934,108 bp
  • C to T, chromosome 17 at 63,863,764 bp
  • C to T, chromosome 18 at 10,122,612 bp
  • A to G, chromosome 18 at 32,086,274 bp
  • G to A, chromosome 18 at 49,920,902 bp
  • G to A, chromosome 19 at 3,371,660 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6892 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044986-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.