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Strain Name:
C57BL/6J-MtgxR6848Btlr/Mmmh
Stock Number:
045022-MU
Citation ID:
RRID:MMRRC_045022-MU
Other Names:
R6848 (G1)
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: Steel Factor Receptor, c-KIT, Dominant white spotting, belly-spot, Tr-kit, SOW3, SCO5, SCO1, Gsfsow3, Gsfsco5, Gsfsco1, CD117
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Nrg1
Name: neuregulin 1
Synonyms: HGL, HRG, Hgl, SMDF, GGF, ARIA, heregulin, D230005F13Rik, HRGalpha, 6030402G23Rik, GGFII, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Cep70
Name: centrosomal protein 70
Synonyms: 6720484E09Rik, C030018L16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68121
Homologene: 11387
Psmb1
Name: proteasome (prosome, macropain) subunit, beta type 1
Synonyms: Lmpc5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19170
VEGA: 17
HGNC: HGNC:9537
Homologene: 2087
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Glur4, spkw1, Gluralpha4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: mCD46, Cdc46, Mcmd5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 65,024,769 bp
  • A to T, chromosome 1 at 127,551,380 bp
  • G to A, chromosome 1 at 136,092,694 bp
  • T to C, chromosome 1 at 172,495,762 bp
  • C to T, chromosome 1 at 175,663,049 bp
  • T to A, chromosome 2 at 9,858,528 bp
  • A to T, chromosome 2 at 82,982,787 bp
  • A to T, chromosome 2 at 87,974,170 bp
  • C to A, chromosome 2 at 131,282,626 bp
  • T to C, chromosome 3 at 40,694,255 bp
  • T to C, chromosome 4 at 63,302,371 bp
  • T to C, chromosome 4 at 116,052,934 bp
  • G to T, chromosome 5 at 35,592,184 bp
  • A to T, chromosome 5 at 75,607,212 bp
  • A to G, chromosome 5 at 104,074,737 bp
  • G to A, chromosome 5 at 107,426,918 bp
  • A to C, chromosome 5 at 109,557,031 bp
  • A to C, chromosome 5 at 112,985,775 bp
  • G to T, chromosome 6 at 92,863,354 bp
  • T to C, chromosome 6 at 116,556,775 bp
  • T to A, chromosome 7 at 66,171,037 bp
  • T to G, chromosome 7 at 68,004,179 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • T to C, chromosome 7 at 85,152,632 bp
  • A to G, chromosome 7 at 103,506,457 bp
  • A to G, chromosome 8 at 31,818,056 bp
  • A to G, chromosome 8 at 64,098,510 bp
  • G to T, chromosome 8 at 75,127,290 bp
  • A to T, chromosome 8 at 86,029,617 bp
  • G to A, chromosome 8 at 122,790,590 bp
  • C to T, chromosome 9 at 4,793,822 bp
  • T to C, chromosome 9 at 7,159,632 bp
  • G to A, chromosome 9 at 99,262,901 bp
  • A to G, chromosome 9 at 117,251,741 bp
  • T to C, chromosome 10 at 31,332,857 bp
  • C to G, chromosome 10 at 78,184,293 bp
  • A to T, chromosome 10 at 108,699,590 bp
  • A to T, chromosome 11 at 54,007,789 bp
  • T to C, chromosome 11 at 69,884,661 bp
  • T to A, chromosome 12 at 69,308,976 bp
  • T to C, chromosome 13 at 59,701,963 bp
  • C to T, chromosome 13 at 74,038,276 bp
  • T to A, chromosome 13 at 74,309,840 bp
  • T to C, chromosome 13 at 74,695,933 bp
  • A to G, chromosome 13 at 112,993,885 bp
  • A to G, chromosome 14 at 16,409,958 bp
  • C to A, chromosome 14 at 64,028,218 bp
  • T to A, chromosome 14 at 88,467,254 bp
  • G to A, chromosome 15 at 9,280,052 bp
  • G to A, chromosome 15 at 76,091,483 bp
  • T to G, chromosome 15 at 102,208,808 bp
  • A to G, chromosome 17 at 15,477,247 bp
  • A to T, chromosome 17 at 23,551,079 bp
  • T to A, chromosome 17 at 25,367,828 bp
  • T to A, chromosome 17 at 25,836,184 bp
  • T to A, chromosome 17 at 63,991,606 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6848 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045022-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.