Strain Name:
C57BL/6J-MtgxR6904Btlr/Mmmh
Stock Number:
045033-MU
Citation ID:
RRID:MMRRC_045033-MU
Other Names:
R6904 (G1)
Major Collection:

Strain Information

Bmp7
Name: bone morphogenetic protein 7
Synonyms: osteogenic protein 1, OP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12162
HGNC: HGNC:1074
Homologene: 20410
Myl12b
Name: myosin, light chain 12B, regulatory
Synonyms: RLC-B, 1500001M02Rik, Mylc2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67938
Homologene: 23407
Snx4
Name: sorting nexin 4
Synonyms: 1810036H14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69150
VEGA: 16
Homologene: 36143
2610021A01Rik
Name: RIKEN cDNA 2610021A01 gene
Type: Gene
Species: Mouse
Chromosome: 7
Xrcc6
Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms: Ku p70, Ku70, G22p1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14375
HGNC: HGNC:4055
Homologene: 37483
Tsc22d1
Name: TSC22 domain family, member 1
Synonyms: TSC-22, Egr5, Tgfb1i4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21807
Homologene: 7573
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77097
Homologene: 64680
Acadvl
Name: acyl-Coenzyme A dehydrogenase, very long chain
Synonyms: VLCAD
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11370
HGNC: HGNC:92
Homologene: 5
Mpdu1
Name: mannose-P-dolichol utilization defect 1
Synonyms: SL15, Supl15h, LEC35
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24070
HGNC: HGNC:7207
Homologene: 3581
Boc
Name: BOC cell adhesion associated, oncogene regulated
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117606
Homologene: 32819
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109332
Homologene: 11276
Pi4kb
Name: phosphatidylinositol 4-kinase beta
Synonyms: ESTM41, Pik4cb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 107650
HGNC: HGNC:8984
Homologene: 6741
Tcf25
Name: transcription factor 25 (basic helix-loop-helix)
Synonyms: 1810041K11Rik, 1100001J13Rik, Nulp1, D8Ertd325e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66855
Homologene: 5701
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, ZFYVE2, A430109M19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Atg4a-ps
Name: autophagy related 4A, pseudogene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 102926
Zbtb1
Name: zinc finger and BTB domain containing 1
Synonyms: C430003J21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268564
Homologene: 8974
Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
Synonyms: Hpk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26411
HGNC: HGNC:6863
Homologene: 5199
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: Myak, 1110062K04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15257
Homologene: 56483
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Jmjd8
Name: jumonji domain containing 8
Synonyms: 2610003J06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72106
Homologene: 12441
Zc3h7a
Name: zinc finger CCCH type containing 7 A
Synonyms: A430104C18Rik, Zc3h7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106205
Homologene: 8563
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67230
Homologene: 23459
Cntn4
Name: contactin 4
Synonyms: BIG-2A, Axcam
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
Or4c119
Name: olfactory receptor family 4 subfamily C member 119
Synonyms: GA_x6K02T2Q125-50635980-50635046, MOR233-15, Olfr1224
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258026
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93880
HGNC: HGNC:8689
Homologene: 87124
B3glct
Name: beta-3-glucosyltransferase
Synonyms: LOC381694, B3galtl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381694
Homologene: 14978
Adam24
Name: ADAM metallopeptidase domain 24
Synonyms: Dtgn5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Angpt1
Name: angiopoietin 1
Synonyms: Ang-1, Angiopoietin-1, 1110046O21Rik, ang1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11600
VEGA: 15
HGNC: HGNC:484
Homologene: 37447
Ndufaf5
Name: NADH:ubiquinone oxidoreductase complex assembly factor 5
Synonyms: 2310003L22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69487
Homologene: 11474
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Prss41
Name: serine protease 41
Synonyms: Tessp1, 4931440B09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71003
Homologene: 28091
Apol7b
Name: apolipoprotein L 7b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 278679
HGNC: HGNC:619
Homologene: 40940
Krt39
Name: keratin 39
Synonyms: 4732494G06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237934
Homologene: 19078
Or52z12
Name: olfactory receptor family 52 subfamily Z member 12
Synonyms: GA_x6K02T2PBJ9-6306819-6307775, MOR31-10, Olfr617
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258838
Homologene: 105208
Or5w17
Name: olfactory receptor family 5 subfamily W member 17
Synonyms: GA_x6K02T2Q125-49257818-49256883, MOR177-10, Olfr1141
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258630
Homologene: 74080
Or4d5
Name: olfactory receptor family 4 subfamily D member 5
Synonyms: GA_x6K02T2PVTD-33799484-33798540, MOR239-6, Olfr984
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258601
VEGA: 9
Homologene: 17314
Zfp456
Name: zinc finger protein 456
Synonyms: Rslcan-13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408065
Homologene: 110878
Klhl3
Name: kelch-like 3
Synonyms: 7530408C15Rik, EG627648
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Oxgr1
Name: oxoglutarate (alpha-ketoglutarate) receptor 1
Synonyms: LOC239283, P2Y15, Gpr80, Gpr99, Cysltr3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239283
VEGA: 14
HGNC: HGNC:4531
Homologene: 25878
Vmn2r30
Name: vomeronasal 2, receptor 30
Synonyms: V2r15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22306
Homologene: 113703
Ankrd33
Name: ankyrin repeat domain 33
Synonyms: A930021G21Rik, Panky
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 208258
VEGA: 15
Homologene: 16992
Or51v15-ps1
Name: olfactory receptor family 51 subfamily V member 15, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-6352653-6351709, MOR4-3P, MOR4-4_p, EG667639, Olfr621-ps1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667639
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 139,731,653 bp
  • A to G, chromosome 2 at 87,753,879 bp
  • G to A, chromosome 2 at 89,156,813 bp
  • T to A, chromosome 2 at 140,188,780 bp
  • A to G, chromosome 2 at 172,872,913 bp
  • G to T, chromosome 3 at 94,993,150 bp
  • A to G, chromosome 3 at 103,645,864 bp
  • A to T, chromosome 3 at 103,777,512 bp
  • G to A, chromosome 4 at 101,910,094 bp
  • A to G, chromosome 5 at 149,739,604 bp
  • A to T, chromosome 6 at 106,697,583 bp
  • A to G, chromosome 7 at 7,312,548 bp
  • C to A, chromosome 7 at 12,806,530 bp
  • C to T, chromosome 7 at 28,137,213 bp
  • A to G, chromosome 7 at 28,986,802 bp
  • T to A, chromosome 7 at 41,626,092 bp
  • T to A, chromosome 7 at 103,584,520 bp
  • A to T, chromosome 7 at 103,629,583 bp
  • G to A, chromosome 8 at 40,681,503 bp
  • T to A, chromosome 8 at 93,060,410 bp
  • G to A, chromosome 8 at 123,400,698 bp
  • T to C, chromosome 9 at 40,101,356 bp
  • T to C, chromosome 9 at 123,173,915 bp
  • T to A, chromosome 10 at 39,821,481 bp
  • T to C, chromosome 10 at 53,349,098 bp
  • T to G, chromosome 10 at 96,002,879 bp
  • T to A, chromosome 11 at 69,658,585 bp
  • T to C, chromosome 11 at 70,014,333 bp
  • T to C, chromosome 11 at 99,519,821 bp
  • C to T, chromosome 11 at 105,835,230 bp
  • C to T, chromosome 12 at 76,386,211 bp
  • T to A, chromosome 13 at 58,030,445 bp
  • A to T, chromosome 13 at 67,366,265 bp
  • A to T, chromosome 14 at 76,506,483 bp
  • T to A, chromosome 14 at 120,022,019 bp
  • T to C, chromosome 15 at 42,459,740 bp
  • G to A, chromosome 15 at 77,423,425 bp
  • G to A, chromosome 15 at 80,374,801 bp
  • A to G, chromosome 15 at 82,029,122 bp
  • G to A, chromosome 15 at 101,117,112 bp
  • A to G, chromosome 16 at 11,145,671 bp
  • A to G, chromosome 16 at 33,294,738 bp
  • A to G, chromosome 16 at 44,491,791 bp
  • T to C, chromosome 17 at 23,837,648 bp
  • G to A, chromosome 17 at 25,829,052 bp
  • A to T, chromosome 17 at 70,977,140 bp
  • T to A, chromosome 18 at 37,401,917 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6904 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045033-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.