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Strain Name:
C57BL/6J-MtgxR6940Btlr/Mmmh
Stock Number:
045054-MU
Citation ID:
RRID:MMRRC_045054-MU
Other Names:
R6940 (G1)
Major Collection:

Strain Information

Prkacb
Name: protein kinase, cAMP dependent, catalytic, beta
Synonyms: cAMP-dependent protein kinase C beta, Pkacb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18749
HGNC: HGNC:9381
Homologene: 121718
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 55935
Homologene: 9087
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Lrrfip1
Name: leucine rich repeat (in FLII) interacting protein 1
Synonyms: FLAP (FLI LRR associated protein), Fliiap1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16978
HGNC: HGNC:6702
Homologene: 48301
Gtf2b
Name: general transcription factor IIB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229906
HGNC: HGNC:4648
Homologene: 1158
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 46,119,268 bp
  • T to C, chromosome 1 at 53,631,677 bp
  • T to A, chromosome 1 at 91,122,413 bp
  • T to C, chromosome 1 at 97,072,901 bp
  • T to C, chromosome 1 at 139,053,417 bp
  • T to G, chromosome 1 at 155,129,268 bp
  • A to T, chromosome 1 at 155,928,551 bp
  • A to G, chromosome 2 at 51,628,136 bp
  • T to C, chromosome 2 at 90,745,514 bp
  • T to A, chromosome 2 at 122,264,055 bp
  • T to A, chromosome 2 at 153,411,764 bp
  • G to A, chromosome 3 at 92,958,234 bp
  • T to C, chromosome 3 at 100,969,515 bp
  • T to C, chromosome 3 at 101,003,702 bp
  • T to A, chromosome 3 at 122,779,032 bp
  • G to A, chromosome 3 at 126,941,972 bp
  • C to A, chromosome 3 at 142,778,255 bp
  • A to T, chromosome 3 at 146,751,499 bp
  • C to T, chromosome 4 at 48,051,486 bp
  • A to G, chromosome 5 at 30,371,643 bp
  • A to G, chromosome 5 at 36,927,531 bp
  • A to T, chromosome 5 at 87,675,023 bp
  • A to T, chromosome 6 at 23,302,492 bp
  • T to C, chromosome 6 at 70,892,402 bp
  • T to C, chromosome 7 at 12,582,416 bp
  • A to C, chromosome 7 at 27,308,944 bp
  • T to C, chromosome 7 at 102,077,887 bp
  • A to G, chromosome 7 at 104,068,413 bp
  • T to C, chromosome 7 at 105,434,896 bp
  • T to C, chromosome 7 at 122,186,146 bp
  • C to T, chromosome 7 at 128,240,298 bp
  • C to A, chromosome 7 at 143,084,810 bp
  • A to G, chromosome 8 at 84,902,095 bp
  • A to T, chromosome 8 at 109,525,191 bp
  • A to G, chromosome 8 at 110,490,611 bp
  • T to C, chromosome 9 at 15,916,800 bp
  • A to T, chromosome 9 at 42,255,427 bp
  • T to A, chromosome 9 at 45,890,898 bp
  • C to A, chromosome 9 at 54,609,097 bp
  • T to C, chromosome 9 at 121,443,718 bp
  • G to T, chromosome 10 at 31,505,977 bp
  • T to C, chromosome 12 at 85,094,574 bp
  • T to C, chromosome 12 at 118,198,768 bp
  • A to G, chromosome 13 at 97,965,530 bp
  • G to C, chromosome 14 at 37,060,095 bp
  • A to G, chromosome 15 at 9,011,919 bp
  • C to A, chromosome 16 at 48,479,845 bp
  • G to A, chromosome 16 at 93,905,965 bp
  • C to A, chromosome 17 at 35,623,226 bp
  • A to T, chromosome 19 at 6,051,184 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6940 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045054-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.