Strain Name:
C57BL/6J-MtgxR6940Btlr/Mmmh
Stock Number:
045054-MU
Citation ID:
RRID:MMRRC_045054-MU
Other Names:
R6940 (G1)
Major Collection:

Strain Information

Prkacb
Name: protein kinase, cAMP dependent, catalytic, beta
Synonyms: cAMP-dependent protein kinase C beta, Pkacb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18749
HGNC: HGNC:9381
Homologene: 121718
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 55935
Homologene: 9087
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Lrrfip1
Name: leucine rich repeat (in FLII) interacting protein 1
Synonyms: FLAP (FLI LRR associated protein), Fliiap1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16978
HGNC: HGNC:6702
Homologene: 48301
Gtf2b
Name: general transcription factor IIB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229906
HGNC: HGNC:4648
Homologene: 1158
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Trak1
Name: trafficking protein, kinesin binding 1
Synonyms: 2310001H13Rik, hyrt
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67095
Homologene: 25103
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Syvn1
Name: synovial apoptosis inhibitor 1, synoviolin
Synonyms: Hrd1, 1200010C09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74126
Homologene: 32700
Sc5d
Name: sterol-C5-desaturase
Synonyms: A830073K23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235293
VEGA: 9
Homologene: 5044
Cckbr
Name: cholecystokinin B receptor
Synonyms: CCK-B/gastrin receptor, CCK2/gastrin, CCK2R, CCKR-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12426
HGNC: HGNC:1571
Homologene: 7258
Morc1
Name: microrchidia 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17450
VEGA: 16
HGNC: HGNC:7198
Homologene: 7843
Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Synonyms: PERK
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13666
HGNC: HGNC:3255
Homologene: 3557
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74044
Homologene: 37826
Armc5
Name: armadillo repeat containing 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233912
Homologene: 32601
Rnf214
Name: ring finger protein 214
Synonyms: D130054N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235315
Homologene: 109357
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: TEC, NOR-1, Nor1, MINOR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Ern2
Name: endoplasmic reticulum to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26918
Homologene: 22687
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: RIP2, RhoGEF, Rho specific exchange factor, D13Bwg1089e, 9230110L08Rik, p190RhoGEF, Rgnef
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1289Clo, b2b1727Clo, b2b1203Clo, b2b1279Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Csn1s1
Name: casein alpha s1
Synonyms: Csna
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12990
HGNC: HGNC:2445
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: PDE5A1, Pde5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Trpm5
Name: transient receptor potential cation channel, subfamily M, member 5
Synonyms: Mtr1, Ltrpc5, 9430099A16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56843
Homologene: 22818
Ppp2r2c
Name: protein phosphatase 2, regulatory subunit B, gamma
Synonyms: IMYPNO1, PR52, 6330548O06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269643
HGNC: HGNC:9306
Homologene: 36386
Cd101
Name: CD101 antigen
Synonyms: LOC381460, Igsf2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 630146
HGNC: HGNC:5949
Homologene: 3142
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Chaf1b
Name: chromatin assembly factor 1, subunit B
Synonyms: 2600017H24Rik, MPHOSPH7, CAF-I 60 kDa subunit, CAF-1 subunit B, CAF-IP60, CAF1P60, CAF1A, CAF1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637908
Homologene: 104040
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Ranbp3l
Name: RAN binding protein 3-like
Synonyms: C130037N17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223332
VEGA: 15
Homologene: 35407
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Lrit1
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Synonyms: Lrrc21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239037
Homologene: 9215
Nol4l
Name: nucleolar protein 4-like
Synonyms: LOC381396, 8430427H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329540
Homologene: 129589
Muc21
Name: mucin 21
Synonyms: epiglycanin, Gm9573
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 672682
Acsbg1
Name: acyl-CoA synthetase bubblegum family member 1
Synonyms: E230019G03Rik, BG1, Lpd, Bgm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 94180
Homologene: 9044
Or51a43
Name: olfactory receptor family 51 subfamily A member 43
Synonyms: GA_x6K02T2PBJ9-6803062-6802118, MOR13-1, Olfr644
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259125
Homologene: 17491
Rnf217
Name: ring finger protein 217
Synonyms: Ibrdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268291
Homologene: 66368
Mr1
Name: major histocompatibility complex, class I-related
Synonyms: MR1, H2ls
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15064
HGNC: HGNC:4975
Homologene: 123981
Tas2r134
Name: taste receptor, type 2, member 134
Synonyms: Tas2r34, T2R134
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 387511
Homologene: 66001
Prox2
Name: prospero homeobox 2
Synonyms: 1700058C01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73422
Homologene: 18421
Klf1
Name: Kruppel-like transcription factor 1 (erythroid)
Synonyms: Eklf, Nan
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16596
HGNC: HGNC:6345
Homologene: 4785
Xndc1
Name: Xrcc1 N-terminal domain containing 1
Synonyms: Xndr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102443350
Homologene: 128476
Sord
Name: sorbitol dehydrogenase
Synonyms: Sodh-1, Sdh-1, Sdh1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20322
Homologene: 56080
Lce3d
Name: late cornified envelope 3D
Synonyms: Gm9782
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 630994
Homologene: 134278
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 46,119,268 bp
  • T to C, chromosome 1 at 53,631,677 bp
  • T to A, chromosome 1 at 91,122,413 bp
  • T to C, chromosome 1 at 97,072,901 bp
  • T to C, chromosome 1 at 139,053,417 bp
  • T to G, chromosome 1 at 155,129,268 bp
  • A to T, chromosome 1 at 155,928,551 bp
  • A to G, chromosome 2 at 51,628,136 bp
  • T to C, chromosome 2 at 90,745,514 bp
  • T to A, chromosome 2 at 122,264,055 bp
  • T to A, chromosome 2 at 153,411,764 bp
  • G to A, chromosome 3 at 92,958,234 bp
  • T to C, chromosome 3 at 100,969,515 bp
  • T to C, chromosome 3 at 101,003,702 bp
  • T to A, chromosome 3 at 122,779,032 bp
  • G to A, chromosome 3 at 126,941,972 bp
  • C to A, chromosome 3 at 142,778,255 bp
  • A to T, chromosome 3 at 146,751,499 bp
  • C to T, chromosome 4 at 48,051,486 bp
  • A to G, chromosome 5 at 30,371,643 bp
  • A to G, chromosome 5 at 36,927,531 bp
  • A to T, chromosome 5 at 87,675,023 bp
  • A to T, chromosome 6 at 23,302,492 bp
  • T to C, chromosome 6 at 70,892,402 bp
  • T to C, chromosome 7 at 12,582,416 bp
  • A to C, chromosome 7 at 27,308,944 bp
  • T to C, chromosome 7 at 102,077,887 bp
  • A to G, chromosome 7 at 104,068,413 bp
  • T to C, chromosome 7 at 105,434,896 bp
  • T to C, chromosome 7 at 122,186,146 bp
  • C to T, chromosome 7 at 128,240,298 bp
  • C to A, chromosome 7 at 143,084,810 bp
  • A to G, chromosome 8 at 84,902,095 bp
  • A to T, chromosome 8 at 109,525,191 bp
  • A to G, chromosome 8 at 110,490,611 bp
  • T to C, chromosome 9 at 15,916,800 bp
  • A to T, chromosome 9 at 42,255,427 bp
  • T to A, chromosome 9 at 45,890,898 bp
  • C to A, chromosome 9 at 54,609,097 bp
  • T to C, chromosome 9 at 121,443,718 bp
  • G to T, chromosome 10 at 31,505,977 bp
  • T to C, chromosome 12 at 85,094,574 bp
  • T to C, chromosome 12 at 118,198,768 bp
  • A to G, chromosome 13 at 97,965,530 bp
  • G to C, chromosome 14 at 37,060,095 bp
  • A to G, chromosome 15 at 9,011,919 bp
  • C to A, chromosome 16 at 48,479,845 bp
  • G to A, chromosome 16 at 93,905,965 bp
  • C to A, chromosome 17 at 35,623,226 bp
  • A to T, chromosome 19 at 6,051,184 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6940 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045054-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.