Strain Name:
C57BL/6J-MtgxR6953Btlr/Mmmh
Stock Number:
045065-MU
Citation ID:
RRID:MMRRC_045065-MU
Other Names:
R6953 (G1)
Major Collection:

Strain Information

Dnmt1
Name: DNA methyltransferase 1
Synonyms: MommeD2, Cxxc9, Dnmt1o, MTase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Ap2m1
Name: adaptor-related protein complex 2, mu 1 subunit
Synonyms: clathrin-associated AP-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11773
HGNC: HGNC:564
Homologene: 3000
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, ASC1p200, Helic1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Sec23ip
Name: Sec23 interacting protein
Synonyms: D7Ertd373e, p125
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207352
Homologene: 38288
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: 2610024N01Rik, Tarsl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71807
Homologene: 23520
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71472
Homologene: 41730
Racgap1
Name: Rac GTPase-activating protein 1
Synonyms: MgcRacGAP, gtl11, Band25, GTPase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26934
HGNC: HGNC:9804
Homologene: 8077
Ccp110
Name: centriolar coiled coil protein 110
Synonyms: 6330503K22Rik, CP110
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101565
Homologene: 8810
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: 5730503J23Rik, Pumm2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80913
Homologene: 69183
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, Gm21044, LOC385009
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Isoc1
Name: isochorismatase domain containing 1
Synonyms: 2610034N03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66307
VEGA: 18
Homologene: 9361
Phactr4
Name: phosphatase and actin regulator 4
Synonyms: 3110001B12Rik, C330013F19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100169
Homologene: 41537
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 170721
Homologene: 71541
Ier3ip1
Name: immediate early response 3 interacting protein 1
Synonyms: 1110057H19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66191
Homologene: 41106
Plcxd2
Name: phosphatidylinositol-specific phospholipase C, X domain containing 2
Synonyms: EG433022
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 433022
Homologene: 44374
Adgrd1
Name: adhesion G protein-coupled receptor D1
Synonyms: Gpr133, E230012M21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243277
Homologene: 34616
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ush2a
Name: usherin
Synonyms: Ushrn, A930037M10Rik, MUSH2A, LOC269160, A930011D15Rik, LOC381317, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Zim1
Name: zinc finger, imprinted 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22776
Homologene: 129793
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
C3ar1
Name: complement component 3a receptor 1
Synonyms: C3aR, anaphylatoxin C3a receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12267
HGNC: HGNC:1319
Homologene: 2992
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56552
Homologene: 135915
Or7e175
Name: olfactory receptor family 7 subfamily E member 175
Synonyms: GA_x6K02T2PVTD-13878275-13879204, MOR145-6, Olfr869
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258550
HGNC: HGNC:8396
Homologene: 138312
Zfp607a
Name: zinc finger protein 607A
Synonyms: 4732475C15Rik, Zfp607
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545938
Homologene: 134321
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83561
Homologene: 12850
Spag17
Name: sperm associated antigen 17
Synonyms: PF6, 4931427F14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74362
Homologene: 52601
Serpina1d
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1D
Synonyms: Spi1-4, PI4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20703
HGNC: HGNC:8941
Homologene: 20103
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Ogfod3
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 3
Synonyms: 1110031I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66179
Homologene: 11640
Or2y10
Name: olfactory receptor family 2 subfamily Y member 10
Synonyms: Olfr1380, GA_x6K02T2QP88-5871967-5871032, MOR256-66_i
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404336
Homologene: 72463
Mrs2
Name: MRS2 magnesium transporter
Synonyms: Mrs2l, LOC380836
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380836
Homologene: 31983
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms: Xpf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50505
HGNC: HGNC:3436
Homologene: 3836
Slc25a21
Name: solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Synonyms: 9930033G19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217593
Homologene: 6988
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
9130401M01Rik
Name: RIKEN cDNA 9130401M01 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75758
Homologene: 12622
Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Synonyms: 25-hydroxyvitamin D-24-hydroxylase, 24-OHase, Cyp24, CP24
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13081
HGNC: HGNC:2602
Homologene: 68094
Dapk2
Name: death-associated protein kinase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13143
HGNC: HGNC:2675
Homologene: 74940
Aadacl2
Name: arylacetamide deacetylase like 2
Synonyms: EG639634
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 639634
Homologene: 28634
Tldc2
Name: TBC/LysM associated domain containing 2
Synonyms: LOC383766, Gm1332
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 383766
Homologene: 31961
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627814
Homologene: 129678
Lcn4
Name: lipocalin 4
Synonyms: Vnsp2, A630045M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16821
Homologene: 86960
Prl3d3
Name: prolactin family 3, subfamily d, member 3
Synonyms: PL-Ig, Plig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 215029
Homologene: 137215
Or2m13
Name: olfactory receptor family 2 subfamily M member 13
Synonyms: GA_x54KRFPKG5P-15855164-15854223, MOR279-1, Olfr165
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258458
Homologene: 128262
Sbspon
Name: somatomedin B and thrombospondin, type 1 domain containing
Synonyms: LOC226866, Gm106
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226866
Homologene: 45950
Ifi211
Name: interferon activated gene 211
Synonyms: Mnda, Ifi205b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381308
Homologene: 115929
Or6c204
Name: olfactory receptor family 6 subfamily C member 204
Synonyms: MOR114-15, GA_x6K02T2PULF-10872859-10871923, Olfr773-ps1, Olfr773
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257664
Homologene: 123776
Zfp551
Name: zinc finger protein 551
Synonyms: 9630004E07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 619331
Homologene: 64631
Vmn2r-ps117
Name: vomeronasal 2, receptor, pseudogene 117
Synonyms: EG665303
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665303
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Pcdhac2
Name: protocadherin alpha subfamily C, 2
Synonyms: CNRc2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353237
HGNC: HGNC:8677
Homologene: 49562
Pcdhgc5
Name: protocadherin gamma subfamily C, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93708
HGNC: HGNC:8718
Homologene: 110933
Smim20
Name: small integral membrane protein 20
Synonyms: 1810013D10Rik, 1110067B18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66278
Homologene: 82612
BC024063
Name: cDNA sequence BC024063
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 666584
VEGA: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 15,860,295 bp
  • A to G, chromosome 1 at 25,826,511 bp
  • T to C, chromosome 1 at 173,906,266 bp
  • A to G, chromosome 1 at 178,874,072 bp
  • A to G, chromosome 1 at 188,263,145 bp
  • A to G, chromosome 2 at 26,669,355 bp
  • T to C, chromosome 2 at 66,319,469 bp
  • A to G, chromosome 2 at 76,771,585 bp
  • T to G, chromosome 2 at 157,089,278 bp
  • T to G, chromosome 2 at 170,487,946 bp
  • A to C, chromosome 3 at 60,024,760 bp
  • T to C, chromosome 3 at 95,753,114 bp
  • T to G, chromosome 3 at 100,034,975 bp
  • T to C, chromosome 4 at 132,377,351 bp
  • T to A, chromosome 5 at 53,277,916 bp
  • A to T, chromosome 5 at 129,115,078 bp
  • G to A, chromosome 6 at 122,850,632 bp
  • T to C, chromosome 6 at 124,039,782 bp
  • T to A, chromosome 7 at 6,687,707 bp
  • A to T, chromosome 7 at 12,416,788 bp
  • T to A, chromosome 7 at 27,878,365 bp
  • T to C, chromosome 7 at 118,722,421 bp
  • C to A, chromosome 7 at 128,752,796 bp
  • T to C, chromosome 9 at 18,640,529 bp
  • A to T, chromosome 9 at 20,138,003 bp
  • G to T, chromosome 9 at 20,918,526 bp
  • C to G, chromosome 9 at 66,254,622 bp
  • T to C, chromosome 9 at 108,498,931 bp
  • A to G, chromosome 10 at 50,645,666 bp
  • T to A, chromosome 10 at 82,107,899 bp
  • A to G, chromosome 10 at 92,994,678 bp
  • A to T, chromosome 10 at 129,186,605 bp
  • A to G, chromosome 11 at 49,564,290 bp
  • A to T, chromosome 11 at 69,741,711 bp
  • A to G, chromosome 11 at 94,374,835 bp
  • A to G, chromosome 11 at 121,202,998 bp
  • T to A, chromosome 12 at 8,728,779 bp
  • T to A, chromosome 12 at 57,159,169 bp
  • G to A, chromosome 12 at 83,781,885 bp
  • G to A, chromosome 12 at 103,767,730 bp
  • C to A, chromosome 13 at 25,001,788 bp
  • A to G, chromosome 13 at 27,161,046 bp
  • T to A, chromosome 14 at 50,891,516 bp
  • C to A, chromosome 15 at 58,028,827 bp
  • T to C, chromosome 15 at 99,626,329 bp
  • T to A, chromosome 16 at 13,130,686 bp
  • C to T, chromosome 16 at 19,407,528 bp
  • T to A, chromosome 16 at 20,542,718 bp
  • T to C, chromosome 16 at 45,980,519 bp
  • T to G, chromosome 17 at 18,824,833 bp
  • G to A, chromosome 17 at 20,540,711 bp
  • A to G, chromosome 18 at 37,144,426 bp
  • C to T, chromosome 18 at 37,690,754 bp
  • C to A, chromosome 18 at 37,820,461 bp
  • A to G, chromosome 18 at 58,671,302 bp
  • C to G, chromosome 18 at 76,939,613 bp
  • C to T, chromosome 19 at 56,831,371 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6953 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045065-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.