Strain Name:
C57BL/6J-MtgxR6954Btlr/Mmmh
Stock Number:
045066-MU
Citation ID:
RRID:MMRRC_045066-MU
Other Names:
R6954 (G1)
Major Collection:

Strain Information

Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Synonyms: Pipk5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18720
HGNC: HGNC:8994
Homologene: 93492
Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Igf1
Name: insulin-like growth factor 1
Synonyms: Igf-1, Igf-I, C730016P09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16000
HGNC: HGNC:5464
Homologene: 515
Hspa12a
Name: heat shock protein 12A
Synonyms: Hspa12a, 1700063D12Rik, Gm19925
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73442
VEGA: 19
Homologene: 18422
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Hsf2
Name: heat shock factor 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15500
VEGA: 10
HGNC: HGNC:5225
Homologene: 37931
Ung
Name: uracil DNA glycosylase
Synonyms: UNG1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22256
Homologene: 6585
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58198
Homologene: 2230
Ccm2
Name: cerebral cavernous malformation 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216527
Homologene: 12868
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, 6530403D07Rik, D2Ertd145e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Vdac1
Name: voltage-dependent anion channel 1
Synonyms: Vdac5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22333
Homologene: 107244
Scfd1
Name: Sec1 family domain containing 1
Synonyms: 3110021P21Rik, STXBP1L2, RA410
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76983
VEGA: 12
Homologene: 5650
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Letm1
Name: leucine zipper-EF-hand containing transmembrane protein 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56384
HGNC: HGNC:6556
Homologene: 56320
Eif2b2
Name: eukaryotic translation initiation factor 2B, subunit 2 beta
Synonyms: EIF-2Bbeta, EIF2B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217715
HGNC: HGNC:3258
Homologene: 6507
Furin
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: Fur, PACE, SPC1, Pcsk3, 9130404I01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, A230083H22Rik, Olfaxin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Sidt2
Name: SID1 transmembrane family, member 2
Synonyms: CGI-40
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214597
Homologene: 22943
Fcrl2
Name: Fc receptor like 2
Synonyms: 2810439C17Rik, IFGP2, Fcrh2, moFcRH2sc, Msr2, Fcrls
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80891
Homologene: 57117
Pprc1
Name: peroxisome proliferative activated receptor, gamma, coactivator-related 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226169
Homologene: 9006
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Zfp280b
Name: zinc finger protein 280B
Synonyms: Suhw2, D10Jhu82e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64453
VEGA: 10
Homologene: 62794
Stxbp1
Name: syntaxin binding protein 1
Synonyms: Unc18h, Munc18-1, Rb-sec1, Sxtbp1, Munc-18a, N-sec1, nsec1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20910
Homologene: 2382
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Slc35b4
Name: solute carrier family 35, member B4
Synonyms: 4930474D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58246
Homologene: 5799
Vmn1r24
Name: vomeronasal 1 receptor 24
Synonyms: V1rc18
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171191
Homologene: 134024
Ctrb1
Name: chymotrypsinogen B1
Synonyms: Prt-2, 2200008D09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66473
Homologene: 88564
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Zkscan4
Name: zinc finger with KRAB and SCAN domains 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544922
Homologene: 128718
Prob1
Name: proline rich basic protein 1
Synonyms: LOC381148, Gm1614
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381148
Homologene: 83773
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LO, 5-LOX, 5LX
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Cntnap3
Name: contactin associated protein-like 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238680
VEGA: 13
Homologene: 129602
Or9g4b
Name: olfactory receptor family 9 subfamily G member 4B
Synonyms: GA_x6K02T2Q125-47264151-47265089, MOR213-3, Olfr1015
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258564
Homologene: 115499
Pik3c2b
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms: PI3K-C2beta, C330011J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240752
HGNC: HGNC:8972
Homologene: 20582
Lypd8l
Name: LY6/PLAUR domain containing 8 like
Synonyms: 2210407C18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78354
Homologene: 87212
B4galnt4
Name: beta-1,4-N-acetyl-galactosaminyl transferase 4
Synonyms: LOC381951
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330671
Homologene: 27982
Tmem69
Name: transmembrane protein 69
Synonyms: A630048M13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230657
Homologene: 9531
Or4k6
Name: olfactory receptor family 4 subfamily K member 6
Synonyms: GA_x6K02T2PMLR-5936117-5935137, MOR246-5, Olfr731
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258360
Homologene: 84579
Tas2r134
Name: taste receptor, type 2, member 134
Synonyms: T2R134, Tas2r34
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 387511
Homologene: 66001
Vgll4
Name: vestigial like family member 4
Synonyms: VGL-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232334
Homologene: 18603
Slc22a6
Name: solute carrier family 22 (organic anion transporter), member 6
Synonyms: mOat1, Oat1, Orctl1, NKT
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18399
VEGA: 19
Homologene: 16813
Gm6309
Name: predicted gene 6309
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622306
Homologene: 86127
Igfbpl1
Name: insulin-like growth factor binding protein-like 1
Synonyms: 2810011G06Rik, IGFBP-like protein, 2810453O06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75426
Homologene: 10292
Slc46a3
Name: solute carrier family 46, member 3
Synonyms: 1200006F02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71706
Homologene: 41733
Slc25a10
Name: solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms: Dic
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27376
Homologene: 6519
4930451I11Rik
Name: RIKEN cDNA 4930451I11 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78118
Homologene: 52331
Tdpoz2
Name: TD and POZ domain containing 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 399673
Homologene: 133956
Tmppe
Name: transmembrane protein with metallophosphoesterase domain
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100504715
VEGA: 9
Homologene: 62675
Mfsd4b4
Name: major facilitator superfamily domain containing 4B4
Synonyms: AA474331
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213332
Gm29106
Name: predicted gene 29106
Type: Gene
Species: Mouse
Chromosome: 1
Tcstv6a
Name: Tcstv family member 6A
Synonyms: D13Ertd608e, Tcstv6
Type: Gene
Species: Mouse
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 105,553,897 bp
  • T to A, chromosome 1 at 118,200,587 bp
  • T to G, chromosome 1 at 133,066,303 bp
  • T to A, chromosome 1 at 139,168,945 bp
  • T to A, chromosome 2 at 32,801,893 bp
  • C to T, chromosome 2 at 51,627,770 bp
  • T to G, chromosome 2 at 52,112,691 bp
  • T to A, chromosome 2 at 85,786,382 bp
  • T to C, chromosome 2 at 127,064,951 bp
  • A to G, chromosome 3 at 87,263,676 bp
  • A to T, chromosome 3 at 93,652,275 bp
  • A to T, chromosome 3 at 95,068,247 bp
  • C to T, chromosome 4 at 45,826,663 bp
  • T to C, chromosome 4 at 116,554,724 bp
  • G to A, chromosome 5 at 33,782,507 bp
  • A to T, chromosome 5 at 75,173,394 bp
  • G to T, chromosome 5 at 114,131,337 bp
  • A to T, chromosome 5 at 146,168,490 bp
  • T to C, chromosome 5 at 147,886,340 bp
  • A to G, chromosome 6 at 34,158,621 bp
  • T to A, chromosome 6 at 35,208,109 bp
  • A to G, chromosome 6 at 57,956,452 bp
  • T to C, chromosome 6 at 114,921,367 bp
  • A to C, chromosome 6 at 116,420,280 bp
  • G to T, chromosome 7 at 80,396,964 bp
  • A to T, chromosome 7 at 126,830,637 bp
  • A to G, chromosome 7 at 141,067,232 bp
  • A to G, chromosome 8 at 25,822,768 bp
  • A to G, chromosome 8 at 71,290,819 bp
  • A to G, chromosome 8 at 89,032,891 bp
  • A to G, chromosome 8 at 111,686,664 bp
  • A to T, chromosome 9 at 45,952,850 bp
  • G to A, chromosome 9 at 114,405,523 bp
  • A to T, chromosome 10 at 39,891,952 bp
  • T to A, chromosome 10 at 57,504,643 bp
  • C to T, chromosome 10 at 74,645,989 bp
  • T to A, chromosome 10 at 76,039,688 bp
  • G to C, chromosome 10 at 87,864,860 bp
  • T to A, chromosome 11 at 6,594,239 bp
  • T to C, chromosome 11 at 52,386,373 bp
  • T to A, chromosome 11 at 58,608,488 bp
  • T to C, chromosome 11 at 80,674,957 bp
  • A to G, chromosome 11 at 118,066,432 bp
  • A to G, chromosome 11 at 120,498,147 bp
  • T to C, chromosome 12 at 51,427,946 bp
  • T to A, chromosome 12 at 85,226,043 bp
  • A to G, chromosome 13 at 21,484,365 bp
  • G to A, chromosome 13 at 64,748,559 bp
  • A to T, chromosome 13 at 100,223,414 bp
  • A to G, chromosome 13 at 119,846,130 bp
  • A to T, chromosome 14 at 50,238,110 bp
  • A to G, chromosome 15 at 76,599,496 bp
  • A to T, chromosome 15 at 85,817,853 bp
  • A to G, chromosome 16 at 14,138,520 bp
  • A to G, chromosome 18 at 35,654,268 bp
  • G to A, chromosome 19 at 8,622,096 bp
  • C to A, chromosome 19 at 17,000,021 bp
  • T to C, chromosome 19 at 46,064,433 bp
  • T to C, chromosome 19 at 58,799,692 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6954 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045066-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.