Strain Name:
C57BL/6J-MtgxR6956Btlr/Mmmh
Stock Number:
045067-MU
Citation ID:
RRID:MMRRC_045067-MU
Other Names:
R6956 (G1)
Major Collection:

Strain Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Vcan
Name: versican
Synonyms: Cspg2, hdf, DPEAAE, PG-M, heart defect, 5430420N07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230484
Homologene: 2528
Psmd3
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Synonyms: AntP91a, Psd3, Tstap91a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22123
HGNC: HGNC:9560
Homologene: 2102
Bmpr1a
Name: bone morphogenetic protein receptor, type 1A
Synonyms: ALK3, Bmpr, BMPR-IA, 1110037I22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12166
HGNC: HGNC:1076
Homologene: 20911
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Socs7
Name: suppressor of cytokine signaling 7
Synonyms: Nap4, 2310063P06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192157
Homologene: 16331
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98956
Homologene: 6785
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: 7330410C13Rik, A630023E24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64706
Homologene: 11224
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7a, LOC381341, Dnahc7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Dcdc2a
Name: doublecortin domain containing 2a
Synonyms: RU2, Dcdc2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195208
Homologene: 9483
Aars1
Name: alanyl-tRNA synthetase 1
Synonyms: Aars
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: KCC1, K-Cl Co-transporter-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20498
Homologene: 21056
Amotl2
Name: angiomotin-like 2
Synonyms: Lccp, MASCOT
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56332
Homologene: 9420
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: MPP9, 9630025B04Rik, B930097C17Rik, MPP-9, 4930548D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Gipc2
Name: GIPC PDZ domain containing family, member 2
Synonyms: Semcap2, 2200002N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54120
Homologene: 22994
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Usp2
Name: ubiquitin specific peptidase 2
Synonyms: ubp41, B930035K21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53376
Homologene: 3098
Rpgrip1l
Name: Rpgrip1-like
Synonyms: Ftm, Nphp8, 1700047E16Rik, fantom
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244585
Homologene: 18296
Fam184b
Name: family with sequence similarity 184, member B
Synonyms: 9630031F12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58227
Homologene: 137353
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: LOC384168, Peplb, Rw, B930011P16Rik, In(5)6H-p, Dpp-6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625068
Homologene: 129606
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: PFK-2/FBPase-2 gene B, 4930568D07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Mboat1
Name: membrane bound O-acyltransferase domain containing 1
Synonyms: 9130215M02Rik, Oact1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218121
Homologene: 57467
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: 4632412N22Rik, Fam179a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320159
Homologene: 65315
C9
Name: complement component 9
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Cc2d1a
Name: coiled-coil and C2 domain containing 1A
Synonyms: Freud-1, Tape
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212139
Homologene: 23040
Tgm4
Name: transglutaminase 4 (prostate)
Synonyms: experimental autoimmune prostatitis antigen 1, Eapa1, 9530008N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331046
Homologene: 20689
Ccdc202
Name: coiled-coil domain containing 202
Synonyms: 4921530L21Rik, Spertl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66732
VEGA: 14
Homologene: 41645
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Gbp11
Name: guanylate binding protein 11
Synonyms: Gm7141
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 634650
Homologene: 128731
Marchf3
Name: membrane associated ring-CH-type finger 3
Synonyms: A530081L18Rik, March3, 6330411I15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 320253
Homologene: 35310
Or6c208
Name: olfactory receptor family 6 subfamily C member 208
Synonyms: Olfr784, MOR110-3, GA_x6K02T2PULF-11068246-11069205
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258724
Homologene: 138306
Nalf1
Name: NALCN channel auxiliary factor 1
Synonyms: Fam155a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270028
Homologene: 83472
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108682
Homologene: 68832
H2-T3
Name: histocompatibility 2, T region locus 3
Synonyms: H2-Tw3, TL, H-2T3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15043
Homologene: 74884
Fam229b
Name: family with sequence similarity 229, member B
Synonyms: 1700025K23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66337
Homologene: 84685
Vmn2r31
Name: vomeronasal 2, receptor 31
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042591
Homologene: 113703
Sult2a6
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6
Synonyms: Gm6957
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 629219
Homologene: 37741
Tdpoz8
Name: TD and POZ domain containing 8
Synonyms: Gm4858
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229571
Homologene: 130121
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 53,577,287 bp
  • T to C, chromosome 1 at 130,707,600 bp
  • T to C, chromosome 2 at 103,734,412 bp
  • T to C, chromosome 2 at 118,422,267 bp
  • T to A, chromosome 3 at 83,353,926 bp
  • T to C, chromosome 3 at 93,073,972 bp
  • A to G, chromosome 3 at 152,094,248 bp
  • A to G, chromosome 3 at 158,289,031 bp
  • A to G, chromosome 4 at 98,931,006 bp
  • A to G, chromosome 4 at 101,614,273 bp
  • A to T, chromosome 5 at 27,598,821 bp
  • T to C, chromosome 5 at 45,530,757 bp
  • A to G, chromosome 5 at 105,328,375 bp
  • T to C, chromosome 5 at 124,297,558 bp
  • T to G, chromosome 6 at 41,687,973 bp
  • G to A, chromosome 7 at 7,394,506 bp
  • T to A, chromosome 7 at 14,254,823 bp
  • T to A, chromosome 8 at 9,770,744 bp
  • G to T, chromosome 8 at 84,135,899 bp
  • G to A, chromosome 8 at 85,518,052 bp
  • A to C, chromosome 8 at 91,286,313 bp
  • A to G, chromosome 8 at 105,953,852 bp
  • G to A, chromosome 8 at 111,055,130 bp
  • T to C, chromosome 9 at 18,645,026 bp
  • T to A, chromosome 9 at 44,092,756 bp
  • A to G, chromosome 9 at 102,724,768 bp
  • G to T, chromosome 9 at 123,064,703 bp
  • T to A, chromosome 10 at 39,133,847 bp
  • A to T, chromosome 10 at 129,388,297 bp
  • C to A, chromosome 10 at 130,389,267 bp
  • T to C, chromosome 11 at 97,377,023 bp
  • T to A, chromosome 11 at 98,695,551 bp
  • T to C, chromosome 11 at 104,318,255 bp
  • A to G, chromosome 12 at 104,731,023 bp
  • A to G, chromosome 12 at 112,036,354 bp
  • T to A, chromosome 13 at 25,119,366 bp
  • T to C, chromosome 13 at 30,238,076 bp
  • T to A, chromosome 13 at 89,689,431 bp
  • A to G, chromosome 14 at 34,441,175 bp
  • T to A, chromosome 14 at 95,882,433 bp
  • A to T, chromosome 15 at 6,445,464 bp
  • A to T, chromosome 15 at 9,684,935 bp
  • T to C, chromosome 15 at 83,721,876 bp
  • T to A, chromosome 17 at 36,189,371 bp
  • T to C, chromosome 17 at 71,729,188 bp
  • A to G, chromosome 18 at 56,775,981 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6956 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045067-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.