Strain Name:
C57BL/6J-MtgxR6963Btlr/Mmmh
Stock Number:
045073-MU
Citation ID:
RRID:MMRRC_045073-MU
Other Names:
R6963 (G1)
Major Collection:

Strain Information

Myo10
Name: myosin X
Synonyms: D15Ertd600e, myosin-X
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Ly6k
Name: lymphocyte antigen 6 family member K
Synonyms: mLy-6K, 3110035B01Rik, 2410015A16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76486
Homologene: 130772
Nrg1
Name: neuregulin 1
Synonyms: GGF, NDF, GGFII, HRG, 6030402G23Rik, SMDF, ARIA, HRGalpha, heregulin, HGL, Hgl, D230005F13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Rnf145
Name: ring finger protein 145
Synonyms: 3732413I11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74315
Homologene: 14427
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, XAP8, Hbxap, C030033M12Rik, p325
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Skp2
Name: S-phase kinase-associated protein 2
Synonyms: FBXL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27401
Homologene: 55942
Pals2
Name: protein associated with LIN7 2, MAGUK family member
Synonyms: Mpp6, P55t, Pals2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56524
Homologene: 22976
Brms1
Name: breast cancer metastasis-suppressor 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107392
VEGA: 19
Homologene: 32260
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Adgrb2
Name: adhesion G protein-coupled receptor B2
Synonyms: Bai2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230775
HGNC: HGNC:944
Homologene: 1288
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: Ccdc132, 8430415E05Rik, 1700034M03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73288
Homologene: 11498
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: Mcmdc1, 9030408O17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Scfd2
Name: Sec1 family domain containing 2
Synonyms: STXBP1L1, E430013M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212986
Homologene: 77411
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244049
Homologene: 69254
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, ST3GalI, Siat4, Siat4a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Gp2
Name: glycoprotein 2 zymogen granule membrane
Synonyms: 2310037I18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67133
HGNC: HGNC:4441
Homologene: 133790
Kdm5d
Name: lysine demethylase 5D
Synonyms: Jarid1d, Smcy, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Gstm3
Name: glutathione S-transferase, mu 3
Synonyms: Fsc2, mGSTM5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14864
HGNC: HGNC:4632
Homologene: 37356
Mcoln2
Name: mucolipin 2
Synonyms: 3300002C04Rik, mucolipidin 2, TRPML2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68279
Homologene: 12258
Pde9a
Name: phosphodiesterase 9A
Synonyms: PDE9A1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18585
HGNC: HGNC:8795
Homologene: 113565
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69047
Homologene: 73463
Abi3
Name: ABI family member 3
Synonyms: 2210414K06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66610
Homologene: 9505
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Myo15b
Name: myosin XVB
Synonyms: E330039G21Rik, LOC380737, LOC217328
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Ggn
Name: gametogenetin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243897
Homologene: 45139
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228846
Homologene: 18598
Idua
Name: iduronidase, alpha-L
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15932
HGNC: HGNC:5391
Homologene: 170
Ccdc149
Name: coiled-coil domain containing 149
Synonyms: Gm447, LOC242997
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503884
Homologene: 65264
Or5b24
Name: olfactory receptor family 5 subfamily B member 24
Synonyms: GA_x6K02T2RE5P-3264213-3265157, Olfr1449, MOR202-34
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258300
Homologene: 17184
Zfp326
Name: zinc finger protein 326
Synonyms: ZAN75, 5730470H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54367
Homologene: 10297
Gm57858
Name: gene model 57858
Synonyms: Ccdc144b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241943
Homologene: 87263
Vmn1r4
Name: vomeronasal 1 receptor 4
Synonyms: C230065D10Rik, V1rc21
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171194
Homologene: 131060
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: 9130203F04Rik, D130016B08Rik, Zfx1b, SIP1, Zfhx1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Igsf21
Name: immunoglobulin superfamily, member 21
Synonyms: LOC230868
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230868
Homologene: 13153
Tekt2
Name: tektin 2
Synonyms: tektin-t
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24084
Homologene: 8043
Asgr1
Name: asialoglycoprotein receptor 1
Synonyms: Asgr-1, Asgr, ASGPR1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11889
HGNC: HGNC:742
Homologene: 1263
Gm5150
Name: predicted gene 5150
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381484
Homologene: 129516
Rfc5
Name: replication factor C (activator 1) 5
Synonyms: 2610020K06Rik, 36kDa, Recc5, 2610209F07Rik, 36.5kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72151
HGNC: HGNC:9973
Homologene: 6730
Zfp1002
Name: zinc finger protein 1002
Synonyms: Gm21994
Type: Gene
Species: Mouse
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 74,681,816 bp
  • T to G, chromosome 2 at 44,988,799 bp
  • A to G, chromosome 2 at 150,255,345 bp
  • T to C, chromosome 2 at 158,200,308 bp
  • A to G, chromosome 3 at 16,006,391 bp
  • A to G, chromosome 3 at 36,050,662 bp
  • A to G, chromosome 3 at 107,967,624 bp
  • A to G, chromosome 3 at 146,172,035 bp
  • T to C, chromosome 4 at 126,324,317 bp
  • CG to C, chromosome 4 at 130,014,362 bp
  • A to G, chromosome 4 at 140,027,730 bp
  • G to A, chromosome 5 at 52,439,097 bp
  • A to G, chromosome 5 at 74,482,209 bp
  • G to A, chromosome 5 at 76,896,456 bp
  • T to A, chromosome 5 at 105,911,493 bp
  • A to G, chromosome 5 at 108,679,775 bp
  • T to A, chromosome 5 at 117,387,866 bp
  • A to G, chromosome 5 at 150,457,844 bp
  • T to C, chromosome 6 at 3,592,577 bp
  • T to C, chromosome 6 at 50,163,655 bp
  • T to C, chromosome 6 at 56,956,784 bp
  • A to G, chromosome 7 at 29,171,582 bp
  • T to C, chromosome 7 at 72,228,056 bp
  • G to A, chromosome 7 at 97,579,910 bp
  • A to G, chromosome 7 at 119,452,897 bp
  • A to G, chromosome 8 at 31,917,662 bp
  • C to T, chromosome 8 at 119,730,267 bp
  • A to G, chromosome 10 at 53,548,617 bp
  • T to C, chromosome 11 at 44,564,277 bp
  • T to C, chromosome 11 at 70,055,968 bp
  • G to A, chromosome 11 at 95,832,741 bp
  • G to T, chromosome 11 at 115,890,714 bp
  • T to C, chromosome 15 at 9,139,428 bp
  • T to C, chromosome 15 at 25,734,063 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • G to C, chromosome 15 at 74,798,582 bp
  • T to C, chromosome 17 at 18,316,587 bp
  • G to T, chromosome 17 at 31,443,887 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • T to A, chromosome 19 at 5,046,653 bp
  • C to T, chromosome 19 at 12,935,638 bp
  • C to A, chromosome Y at 937,975 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6963 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045073-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.