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Strain Name:
C57BL/6J-MtgxR6964Btlr/Mmmh
Stock Number:
045074-MU
Citation ID:
RRID:MMRRC_045074-MU
Other Names:
R6964 (G1)
Major Collection:

Strain Information

Gfap
Name: glial fibrillary acidic protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14580
HGNC: HGNC:4235
Homologene: 1554
Dclre1c
Name: DNA cross-link repair 1C
Synonyms: 9930121L06Rik, Artemis, Art
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227525
Homologene: 32547
Tacr3
Name: tachykinin receptor 3
Synonyms: neuromedin K receptor, Tac3r, Nk3r
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21338
Homologene: 824
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Ambra1
Name: autophagy/beclin 1 regulator 1
Synonyms: 2310079H06Rik, D030051N19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228361
Homologene: 18204
Eif3e
Name: eukaryotic translation initiation factor 3, subunit E
Synonyms: eIF3-p48, eIF3-p46, Int6, 48kDa, Eif3s6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16341
VEGA: 15
HGNC: HGNC:3277
Homologene: 1205
Bcl7a
Name: B cell CLL/lymphoma 7A
Synonyms: 4432415N06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77045
HGNC: HGNC:1004
Homologene: 10869
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 16,390,005 bp
  • T to C, chromosome 1 at 36,796,292 bp
  • T to C, chromosome 1 at 75,260,649 bp
  • T to A, chromosome 1 at 80,503,648 bp
  • A to T, chromosome 1 at 130,657,272 bp
  • T to C, chromosome 2 at 3,453,169 bp
  • T to A, chromosome 2 at 29,197,029 bp
  • T to C, chromosome 2 at 76,714,113 bp
  • T to C, chromosome 2 at 87,607,613 bp
  • T to A, chromosome 2 at 89,574,989 bp
  • C to T, chromosome 2 at 91,917,416 bp
  • T to A, chromosome 2 at 181,230,428 bp
  • T to C, chromosome 3 at 134,829,739 bp
  • A to G, chromosome 4 at 40,225,697 bp
  • A to G, chromosome 4 at 86,156,854 bp
  • A to G, chromosome 5 at 7,975,568 bp
  • A to T, chromosome 5 at 92,566,052 bp
  • T to C, chromosome 5 at 123,369,456 bp
  • C to T, chromosome 5 at 137,957,497 bp
  • C to T, chromosome 5 at 142,960,660 bp
  • T to G, chromosome 5 at 149,581,850 bp
  • C to T, chromosome 6 at 13,082,423 bp
  • A to C, chromosome 6 at 23,583,459 bp
  • A to G, chromosome 6 at 47,516,509 bp
  • C to T, chromosome 6 at 97,305,197 bp
  • T to A, chromosome 6 at 124,999,390 bp
  • T to A, chromosome 7 at 12,489,592 bp
  • G to A, chromosome 7 at 30,657,615 bp
  • T to A, chromosome 7 at 66,909,400 bp
  • A to G, chromosome 7 at 67,004,353 bp
  • A to G, chromosome 7 at 79,600,531 bp
  • A to T, chromosome 7 at 107,933,759 bp
  • A to G, chromosome 7 at 142,439,421 bp
  • T to A, chromosome 8 at 25,811,823 bp
  • T to G, chromosome 8 at 45,043,945 bp
  • G to A, chromosome 8 at 75,051,965 bp
  • C to T, chromosome 8 at 83,165,952 bp
  • A to G, chromosome 8 at 104,543,581 bp
  • G to C, chromosome 9 at 8,112,100 bp
  • C to T, chromosome 10 at 83,191,381 bp
  • A to T, chromosome 11 at 62,724,817 bp
  • G to A, chromosome 11 at 69,309,491 bp
  • G to A, chromosome 11 at 102,896,957 bp
  • C to T, chromosome 11 at 109,603,764 bp
  • A to C, chromosome 12 at 35,119,789 bp
  • T to A, chromosome 12 at 75,375,389 bp
  • T to C, chromosome 12 at 81,773,003 bp
  • T to A, chromosome 13 at 41,032,591 bp
  • C to T, chromosome 13 at 119,450,770 bp
  • A to T, chromosome 14 at 45,465,142 bp
  • A to T, chromosome 14 at 55,099,265 bp
  • G to A, chromosome 15 at 43,272,289 bp
  • A to G, chromosome 15 at 83,547,931 bp
  • G to A, chromosome 16 at 11,149,224 bp
  • A to G, chromosome 16 at 31,880,162 bp
  • A to G, chromosome 16 at 91,681,219 bp
  • A to T, chromosome 16 at 98,065,759 bp
  • G to T, chromosome 17 at 48,272,819 bp
  • T to A, chromosome 19 at 13,471,361 bp
  • A to C, chromosome 19 at 43,798,076 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6964 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045074-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.