Strain Name:
C57BL/6J-MtgxR6987Btlr/Mmmh
Stock Number:
045094-MU
Citation ID:
RRID:MMRRC_045094-MU
Other Names:
R6987 (G1)
Major Collection:

Strain Information

Elavl4
Name: ELAV like RNA binding protein 4
Synonyms: Hud
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15572
HGNC: HGNC:3315
Homologene: 40729
Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: Nos-1, nNOS, 2310005C01Rik, bNOS, NO
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Enc1
Name: ectodermal-neural cortex 1
Synonyms: PIG10, Nrpb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13803
VEGA: 13
HGNC: HGNC:3345
Homologene: 2694
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, Depdc2, C030045D06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Taf15
Name: TATA-box binding protein associated factor 15
Synonyms: 68kDa, TAFII68, 2610111C21Rik, Taf2n
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70439
Homologene: 131088
Ttc27
Name: tetratricopeptide repeat domain 27
Synonyms: 2610511O17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74196
VEGA: 17
Homologene: 41191
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212281
Homologene: 133713
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F37S1, D15F32S1h, D7H15F32S1, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Trp53bp2
Name: transformation related protein 53 binding protein 2
Synonyms: 53BP2, ASPP2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 209456
Homologene: 3959
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Cnr1
Name: cannabinoid receptor 1
Synonyms: CB1R, CB1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12801
HGNC: HGNC:2159
Homologene: 7273
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Ccdc3
Name: coiled-coil domain containing 3
Synonyms: 2310045O21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74186
Homologene: 12870
Akt2
Name: thymoma viral proto-oncogene 2
Synonyms: PKBbeta, 2410016A19Rik, PKB
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11652
HGNC: HGNC:392
Homologene: 48773
Sptb
Name: spectrin beta, erythrocytic
Synonyms: LOC383567, brain erythroid spectrin (235E), spectrin R, D330027P03Rik, Spnb-1, Spnb1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20741
Homologene: 295
Tes
Name: testin LIM domain protein
Synonyms: testin, Tes1, Tes2, testin2, D6Ertd352e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21753
Homologene: 41051
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: Pla2epsilon, 2310026J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329502
Homologene: 65339
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Cldnd1
Name: claudin domain containing 1
Synonyms: Cldn25, 1110019C08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224250
HGNC: HGNC:1322
Homologene: 10534
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Vmn1r69
Name: vomeronasal 1 receptor 69
Synonyms: V1re9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252904
Homologene: 120153
Osbp2
Name: oxysterol binding protein 2
Synonyms: ORP-4, C630001G20Rik, OSBPL1, 1700095P05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74309
HGNC: HGNC:8504
Homologene: 75303
Npas3
Name: neuronal PAS domain protein 3
Synonyms: 4930423H22Rik, bHLHe12
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Vmn1r124
Name: vomeronasal 1 receptor 124
Synonyms: Gm9500
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 670764
Homologene: 104166
Ccdc148
Name: coiled-coil domain containing 148
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227933
Homologene: 16353
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Masp1
Name: MBL associated serine protease 1
Synonyms: Crarf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
Or8b12i
Name: olfactory receptor family 8 subfamily B member 12I
Synonyms: Olfr870, MOR141-1, GA_x6K02T2PVTD-13912679-13911744
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57251
Homologene: 138319
Adam10
Name: a disintegrin and metallopeptidase domain 10
Synonyms: kuzbanian, kuz, 1700031C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11487
HGNC: HGNC:188
Homologene: 865
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68802
VEGA: 10
Homologene: 23778
Agtr1b
Name: angiotensin II receptor, type 1b
Synonyms: Agtr-1b, Angtr-1b, AT1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11608
HGNC: HGNC:336
Homologene: 84871
Tmem168
Name: transmembrane protein 168
Synonyms: 8430437G11Rik, 5730526F17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101118
Homologene: 11202
Zfp882
Name: zinc finger protein 882
Synonyms: ENSMUSG00000052439
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382019
Homologene: 136303
Cyp2c40
Name: cytochrome P450, family 2, subfamily c, polypeptide 40
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13099
Homologene: 74936
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: Nhe9, 5730527A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331004
Homologene: 69753
Prr14
Name: proline rich 14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233895
Homologene: 11424
Or5p4
Name: olfactory receptor family 5 subfamily P member 4
Synonyms: MOR204-39, MOR204-2, Olfr481, GA_x6K02T2PBJ9-10409785-10410723
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258927
Homologene: 105166
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Zfp850
Name: zinc finger protein 850
Synonyms: C130069I09Rik, Gm4636
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043772
Pira12
Name: paired-Ig-like receptor A12
Synonyms: Gm14548
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100038909
Homologene: 134028
Ffar2
Name: free fatty acid receptor 2
Synonyms: Gpr43
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233079
HGNC: HGNC:4501
Homologene: 133911
Trav14-1
Name: T cell receptor alpha variable 14-1
Synonyms: Gm5770
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 436467
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 11,170,752 bp
  • A to T, chromosome 1 at 182,446,635 bp
  • T to A, chromosome 2 at 5,138,304 bp
  • C to A, chromosome 2 at 58,982,914 bp
  • C to T, chromosome 2 at 82,948,286 bp
  • C to T, chromosome 2 at 120,186,380 bp
  • A to C, chromosome 3 at 20,316,421 bp
  • A to G, chromosome 4 at 33,944,739 bp
  • A to T, chromosome 4 at 110,251,405 bp
  • C to T, chromosome 5 at 117,895,785 bp
  • T to A, chromosome 6 at 13,591,477 bp
  • C to A, chromosome 6 at 17,086,155 bp
  • T to A, chromosome 6 at 91,234,229 bp
  • A to G, chromosome 7 at 3,897,661 bp
  • A to G, chromosome 7 at 10,580,564 bp
  • A to T, chromosome 7 at 21,259,818 bp
  • G to T, chromosome 7 at 27,633,241 bp
  • A to T, chromosome 7 at 27,990,001 bp
  • A to G, chromosome 7 at 30,819,683 bp
  • G to A, chromosome 7 at 56,106,453 bp
  • C to A, chromosome 7 at 105,704,585 bp
  • C to A, chromosome 7 at 108,081,131 bp
  • A to G, chromosome 7 at 127,473,805 bp
  • T to A, chromosome 8 at 71,914,673 bp
  • A to T, chromosome 9 at 20,170,834 bp
  • A to G, chromosome 9 at 70,722,696 bp
  • A to G, chromosome 9 at 94,669,990 bp
  • A to G, chromosome 9 at 118,558,532 bp
  • A to G, chromosome 10 at 39,074,279 bp
  • T to C, chromosome 10 at 63,193,131 bp
  • T to C, chromosome 10 at 127,575,005 bp
  • T to C, chromosome 11 at 3,717,958 bp
  • A to G, chromosome 11 at 8,902,575 bp
  • A to G, chromosome 11 at 72,855,514 bp
  • C to A, chromosome 11 at 83,484,695 bp
  • A to G, chromosome 12 at 54,068,253 bp
  • A to G, chromosome 12 at 76,613,247 bp
  • C to A, chromosome 12 at 112,025,593 bp
  • T to A, chromosome 13 at 67,619,939 bp
  • T to C, chromosome 13 at 97,245,636 bp
  • C to T, chromosome 14 at 53,554,459 bp
  • C to A, chromosome 16 at 23,513,915 bp
  • A to G, chromosome 16 at 58,731,371 bp
  • T to A, chromosome 16 at 77,077,180 bp
  • A to G, chromosome 17 at 30,662,091 bp
  • C to T, chromosome 17 at 56,269,900 bp
  • T to C, chromosome 17 at 74,777,741 bp
  • A to G, chromosome 19 at 39,812,767 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6987 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045094-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.