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Strain Name:
C57BL/6J-MtgxR7000Btlr/Mmmh
Stock Number:
045105-MU
Citation ID:
RRID:MMRRC_045105-MU
Other Names:
R7000 (G1)
Major Collection:

Strain Information

Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Synonyms: Acra7, alpha7, alpha7 nicotinic receptor, alpha7-nAChR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11441
Homologene: 593
Elf1
Name: E74 like ETS transcription factor 1
Synonyms: Elf-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13709
VEGA: 14
HGNC: HGNC:3316
Homologene: 7303
Scarb2
Name: scavenger receptor class B, member 2
Synonyms: LIMP II, LGP85, Cd36l2, LIMP-2, 9330185J12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12492
HGNC: HGNC:1665
Homologene: 48353
Auts2
Name: autism susceptibility candidate 2
Synonyms: D830032G16Rik, A730011F23Rik, 2700063G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319974
Homologene: 22907
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, D430004I05Rik, A130082H20Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 82,497,330 bp
  • T to C, chromosome 1 at 135,889,954 bp
  • T to A, chromosome 1 at 153,166,127 bp
  • C to T, chromosome 1 at 164,179,506 bp
  • T to C, chromosome 1 at 185,349,856 bp
  • G to A, chromosome 2 at 22,942,041 bp
  • A to G, chromosome 2 at 25,467,816 bp
  • G to A, chromosome 2 at 102,611,623 bp
  • A to T, chromosome 2 at 103,712,442 bp
  • T to C, chromosome 2 at 132,094,203 bp
  • G to A, chromosome 2 at 140,660,884 bp
  • C to T, chromosome 2 at 157,216,977 bp
  • T to G, chromosome 3 at 67,462,371 bp
  • T to C, chromosome 3 at 86,987,773 bp
  • G to A, chromosome 3 at 87,988,379 bp
  • T to C, chromosome 3 at 89,402,242 bp
  • C to T, chromosome 3 at 96,580,467 bp
  • G to A, chromosome 3 at 108,876,648 bp
  • C to A, chromosome 3 at 129,872,873 bp
  • T to C, chromosome 4 at 14,552,476 bp
  • A to T, chromosome 4 at 43,556,302 bp
  • A to T, chromosome 4 at 96,447,351 bp
  • T to A, chromosome 4 at 107,209,580 bp
  • C to A, chromosome 4 at 111,937,025 bp
  • C to T, chromosome 4 at 139,414,404 bp
  • A to T, chromosome 4 at 144,195,327 bp
  • G to A, chromosome 4 at 148,929,236 bp
  • G to A, chromosome 4 at 155,903,849 bp
  • G to A, chromosome 5 at 8,702,823 bp
  • A to G, chromosome 5 at 36,821,869 bp
  • T to C, chromosome 5 at 92,454,075 bp
  • A to G, chromosome 5 at 120,695,083 bp
  • T to A, chromosome 5 at 131,440,218 bp
  • T to A, chromosome 5 at 142,960,627 bp
  • T to A, chromosome 5 at 145,463,170 bp
  • C to A, chromosome 6 at 37,958,678 bp
  • A to G, chromosome 6 at 50,297,157 bp
  • A to G, chromosome 6 at 87,434,193 bp
  • T to G, chromosome 6 at 136,612,838 bp
  • T to A, chromosome 7 at 23,894,337 bp
  • A to T, chromosome 7 at 43,476,830 bp
  • T to C, chromosome 7 at 45,475,274 bp
  • A to G, chromosome 7 at 46,005,522 bp
  • A to G, chromosome 7 at 63,106,039 bp
  • A to G, chromosome 7 at 83,882,779 bp
  • A to T, chromosome 7 at 85,559,611 bp
  • A to T, chromosome 7 at 100,106,658 bp
  • A to T, chromosome 7 at 104,841,285 bp
  • G to A, chromosome 7 at 104,975,131 bp
  • T to C, chromosome 8 at 84,928,969 bp
  • A to G, chromosome 8 at 109,530,589 bp
  • A to T, chromosome 9 at 35,235,264 bp
  • T to C, chromosome 9 at 39,600,789 bp
  • G to C, chromosome 9 at 57,615,948 bp
  • T to C, chromosome 9 at 63,454,610 bp
  • A to C, chromosome 9 at 99,322,153 bp
  • A to G, chromosome 10 at 20,443,292 bp
  • T to C, chromosome 10 at 51,615,047 bp
  • T to A, chromosome 10 at 53,298,199 bp
  • T to C, chromosome 10 at 58,222,992 bp
  • T to C, chromosome 10 at 86,080,252 bp
  • T to C, chromosome 10 at 107,779,831 bp
  • T to G, chromosome 11 at 49,216,379 bp
  • A to G, chromosome 11 at 59,136,038 bp
  • C to T, chromosome 11 at 69,817,756 bp
  • T to C, chromosome 11 at 113,803,169 bp
  • T to C, chromosome 11 at 118,025,702 bp
  • A to T, chromosome 12 at 32,192,129 bp
  • G to A, chromosome 12 at 86,244,184 bp
  • C to A, chromosome 12 at 118,017,661 bp
  • A to G, chromosome 13 at 74,058,325 bp
  • A to G, chromosome 13 at 74,182,166 bp
  • C to T, chromosome 13 at 100,534,962 bp
  • C to T, chromosome 14 at 13,679,108 bp
  • A to T, chromosome 14 at 51,573,961 bp
  • A to T, chromosome 14 at 52,171,450 bp
  • A to G, chromosome 14 at 79,570,768 bp
  • A to T, chromosome 15 at 54,752,347 bp
  • C to G, chromosome 17 at 43,627,708 bp
  • T to A, chromosome 18 at 37,726,893 bp
  • T to C, chromosome 18 at 77,372,433 bp
  • G to T, chromosome 19 at 10,710,329 bp
  • A to G, chromosome 19 at 13,364,623 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7000 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045105-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.