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Strain Name:
C57BL/6J-MtgxR7007Btlr/Mmmh
Stock Number:
045109-MU
Citation ID:
RRID:MMRRC_045109-MU
Other Names:
R7007 (G1)
Major Collection:

Strain Information

Tyr
Name: tyrosinase
Synonyms: skc35, Oca1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22173
Homologene: 30969
Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Htr5b
Name: 5-hydroxytryptamine (serotonin) receptor 5B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15564
Homologene: 74951
Rcan2
Name: regulator of calcineurin 2
Synonyms: MCIP2, ZAKI-4, Csp2, Dscr1l1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Tkfc
Name: triokinase, FMN cyclase
Synonyms: Dak
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225913
VEGA: 19
Homologene: 56710
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 17,004,186 bp
  • C to A, chromosome 1 at 31,190,427 bp
  • A to G, chromosome 1 at 45,378,449 bp
  • T to A, chromosome 1 at 46,532,750 bp
  • C to A, chromosome 1 at 58,330,892 bp
  • A to G, chromosome 1 at 121,510,494 bp
  • T to C, chromosome 1 at 131,319,537 bp
  • T to A, chromosome 1 at 179,610,568 bp
  • G to A, chromosome 1 at 184,037,217 bp
  • G to A, chromosome 1 at 192,693,826 bp
  • A to T, chromosome 2 at 28,451,159 bp
  • T to C, chromosome 2 at 32,402,306 bp
  • G to A, chromosome 2 at 76,707,046 bp
  • A to G, chromosome 2 at 87,809,886 bp
  • G to A, chromosome 3 at 18,097,618 bp
  • G to A, chromosome 3 at 19,969,973 bp
  • T to C, chromosome 3 at 94,364,071 bp
  • A to C, chromosome 4 at 41,206,221 bp
  • A to T, chromosome 4 at 47,471,881 bp
  • T to A, chromosome 4 at 63,166,480 bp
  • T to C, chromosome 5 at 124,787,426 bp
  • T to A, chromosome 5 at 127,359,615 bp
  • G to A, chromosome 5 at 146,483,837 bp
  • G to A, chromosome 5 at 148,352,446 bp
  • G to C, chromosome 6 at 84,113,980 bp
  • A to G, chromosome 6 at 126,866,476 bp
  • T to C, chromosome 7 at 12,971,215 bp
  • A to T, chromosome 7 at 16,946,256 bp
  • A to T, chromosome 7 at 19,673,357 bp
  • A to G, chromosome 7 at 44,757,763 bp
  • G to A, chromosome 7 at 87,493,340 bp
  • A to T, chromosome 8 at 3,476,309 bp
  • T to C, chromosome 9 at 44,090,042 bp
  • C to T, chromosome 10 at 88,553,412 bp
  • A to T, chromosome 10 at 120,952,232 bp
  • A to T, chromosome 10 at 129,487,408 bp
  • A to G, chromosome 11 at 5,689,168 bp
  • G to A, chromosome 11 at 49,524,184 bp
  • A to G, chromosome 11 at 67,288,316 bp
  • A to G, chromosome 11 at 79,447,023 bp
  • T to A, chromosome 11 at 83,520,620 bp
  • G to A, chromosome 11 at 116,767,007 bp
  • T to C, chromosome 11 at 118,118,871 bp
  • T to G, chromosome 13 at 49,436,705 bp
  • T to C, chromosome 13 at 50,423,772 bp
  • C to T, chromosome 13 at 54,738,256 bp
  • T to A, chromosome 13 at 59,703,634 bp
  • T to A, chromosome 13 at 81,536,364 bp
  • C to T, chromosome 14 at 36,095,164 bp
  • A to T, chromosome 14 at 54,616,709 bp
  • T to C, chromosome 15 at 64,704,716 bp
  • A to T, chromosome 15 at 82,093,999 bp
  • T to C, chromosome 16 at 3,865,927 bp
  • T to C, chromosome 16 at 10,511,307 bp
  • T to A, chromosome 16 at 18,620,939 bp
  • T to G, chromosome 16 at 33,226,939 bp
  • G to A, chromosome 16 at 50,202,488 bp
  • T to C, chromosome 17 at 23,683,078 bp
  • C to T, chromosome 17 at 43,836,325 bp
  • C to T, chromosome 17 at 57,218,809 bp
  • C to T, chromosome 17 at 71,709,643 bp
  • T to C, chromosome 18 at 12,210,548 bp
  • T to A, chromosome 19 at 4,744,145 bp
  • C to T, chromosome 19 at 5,274,517 bp
  • T to A, chromosome 19 at 10,596,363 bp
  • T to A, chromosome 19 at 34,112,097 bp
  • T to A, chromosome 19 at 47,071,211 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7007 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045109-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.