Strain Name:
C57BL/6J-MtgxR7015Btlr/Mmmh
Stock Number:
045116-MU
Citation ID:
RRID:MMRRC_045116-MU
Other Names:
R7015 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: Gmt1, Eaat1, B430115D02Rik, MGluT1, GLAST
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20512
Homologene: 20882
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20562
Homologene: 2302
Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, 1700008J19Rik, Ankycorbin, Norpeg
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: BCATc, Bcat-1, Eca39
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Zranb2
Name: zinc finger, RAN-binding domain containing 2
Synonyms: Zis, Zfp265, Znf265
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53861
Aplf
Name: aprataxin and PNKP like factor
Synonyms: 2010301N04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72103
Homologene: 49753
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Tara, Mus EST 478828, EST478828
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: D130072O21Rik, Parp5a, 4930554K12Rik, mTNKS1, TANK1, tankyrase 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21951
Homologene: 18405
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: GMAP-210, TRIP230, 3110031G15Rik, 6030460N08Rik, 2610511G22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109181
Homologene: 20897
Rack1
Name: receptor for activated C kinase 1
Synonyms: Gnb2-rs1, p205, GB-like, Gnb2l1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14694
HGNC: HGNC:4399
Homologene: 4446
Ergic1
Name: endoplasmic reticulum-golgi intermediate compartment 1
Synonyms: 1200007D18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67458
Homologene: 41667
Cog3
Name: component of oligomeric golgi complex 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338337
VEGA: 14
Homologene: 5854
Tjap1
Name: tight junction associated protein 1
Synonyms: Tjp4, Pilt, 0610041D19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74094
VEGA: 17
Homologene: 12534
Pdcd11
Name: programmed cell death 11
Synonyms: 1110021I22Rik, ALG-4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, MAP1C, Swl, Dnec1, Loa, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Or51e2
Name: olfactory receptor family 51 subfamily E member 2
Synonyms: MOL2.3, Olfr78, MOR18-2, 4633402A21Rik, RA1c, PSGR, GA_x6K02T2PBJ9-5459657-5458695
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 170639
Homologene: 23713
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: D4Ertd659e, FLASH
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: 1200013F24Rik, SRrp53
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66880
Homologene: 41147
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216766
Homologene: 9155
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: D430002O22Rik, LOC381127, D930044O18Rik, C230079D11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211961
Homologene: 19371
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Me2
Name: malic enzyme 2, NAD(+)-dependent, mitochondrial
Synonyms: D030040L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107029
VEGA: 18
HGNC: HGNC:6984
Homologene: 37615
Camk1
Name: calcium/calmodulin-dependent protein kinase I
Synonyms: CaMKIalpha, Camk, D6Ertd263e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52163
HGNC: HGNC:1459
Homologene: 117458
Foxn4
Name: forkhead box N4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116810
Homologene: 17526
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101056073
Il11ra1
Name: interleukin 11 receptor subunit alpha 1
Synonyms: Il-11ra, NR1, Il11ra, Il-11ra-alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16157
HGNC: HGNC:5967
Homologene: 88705
Ptprh
Name: protein tyrosine phosphatase receptor type H
Synonyms: SAP-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545902
HGNC: HGNC:9672
Homologene: 37693
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20663
Homologene: 38253
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Sh3md1, 2310014D11Rik, Fish, Tks5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231238
Homologene: 9054
Mroh3
Name: maestro heat-like repeat family member 3
Synonyms: 2310006M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76422
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Myo15b
Name: myosin XVB
Synonyms: LOC380737, E330039G21Rik, LOC217328
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Ss18l2
Name: SS18, nBAF chromatin remodeling complex subunit like 2
Synonyms: Band 47B, 1110020I04Rik, Deb1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26901
VEGA: 9
Homologene: 32307
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233437
Homologene: 115466
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Tas2r120
Name: taste receptor, type 2, member 120
Synonyms: mGR20, T2R20, Tas2r20, mt2r47
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387348
Homologene: 135705
Or52a24
Name: olfactory receptor family 52 subfamily A member 24
Synonyms: MOR22-4P, MOR22-1, MOR22-4P, Olfr628, Olfr1526-ps1, GA_x6K02T2PBJ9-6457667-6458617
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259159
Homologene: 8420
Rab34
Name: RAB34, member RAS oncogene family
Synonyms: Narr, Rah1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19376
Homologene: 12908
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: 4632412N22Rik, Fam179a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320159
Homologene: 65315
Iglon5
Name: IgLON family member 5
Synonyms: A230106M20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210094
Homologene: 46295
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: Clip 170, Clip50, CLIP-170, 4631429H07Rik, cytoplasmic linker protein 50, Rsn, restin, 1110007I12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4931433A01Rik, 4930578N11Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: Glurbeta2, Glur-6, C130030K03Rik, Glur6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Ugt2b5
Name: UDP glucuronosyltransferase 2 family, polypeptide B5
Synonyms: Udpgt-3, m-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22238
Homologene: 137225
Ncoa5
Name: nuclear receptor coactivator 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228869
Homologene: 32496
Rsph9
Name: radial spoke head 9 homolog (Chlamydomonas)
Synonyms: 1700027N10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75564
Homologene: 12606
Mrps9
Name: mitochondrial ribosomal protein S9
Synonyms: 2310002A08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69527
Homologene: 32565
Mmp24
Name: matrix metallopeptidase 24
Synonyms: MT5-MMP, Membrane type 5-MMP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17391
HGNC: HGNC:7172
Homologene: 21331
Or4d5
Name: olfactory receptor family 4 subfamily D member 5
Synonyms: Olfr984, GA_x6K02T2PVTD-33799484-33798540, MOR239-6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258601
VEGA: 9
Homologene: 17314
Srd5a2
Name: steroid 5 alpha-reductase 2
Synonyms: 5ART2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 94224
VEGA: 17
Homologene: 37292
Med24
Name: mediator complex subunit 24
Synonyms: DRIP100, Trap100, Gse2, Pparb2, R75526, D11Ertd307e, Thrap4, 100kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
4930523C07Rik
Name: RIKEN cDNA 4930523C07 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67647
Homologene: 124386
Gm21905
Name: predicted gene, 21905
Type: Gene
Species: Mouse
Chromosome: 5
Cd300ld4
Name: CD300 molecule like family member D4
Synonyms: Gm11710
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100043123
Homologene: 129719
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 42,898,546 bp
  • A to G, chromosome 1 at 58,282,758 bp
  • G to A, chromosome 1 at 82,506,950 bp
  • A to T, chromosome 1 at 136,183,331 bp
  • A to G, chromosome 1 at 160,075,168 bp
  • A to G, chromosome 2 at 155,792,624 bp
  • A to G, chromosome 2 at 165,002,081 bp
  • C to T, chromosome 3 at 66,994,649 bp
  • A to T, chromosome 3 at 157,536,733 bp
  • T to C, chromosome 4 at 32,644,278 bp
  • A to T, chromosome 4 at 41,765,421 bp
  • A to G, chromosome 4 at 110,478,500 bp
  • G to T, chromosome 4 at 145,536,635 bp
  • A to T, chromosome 5 at 53,172,574 bp
  • A to T, chromosome 5 at 67,946,362 bp
  • A to G, chromosome 5 at 87,139,796 bp
  • G to A, chromosome 5 at 114,256,855 bp
  • T to C, chromosome 5 at 123,613,612 bp
  • G to A, chromosome 6 at 87,641,902 bp
  • T to C, chromosome 6 at 113,341,926 bp
  • T to C, chromosome 6 at 132,657,165 bp
  • G to C, chromosome 6 at 145,039,583 bp
  • C to A, chromosome 7 at 4,552,627 bp
  • T to C, chromosome 7 at 43,476,927 bp
  • T to C, chromosome 7 at 84,995,558 bp
  • C to A, chromosome 7 at 102,742,444 bp
  • T to C, chromosome 7 at 103,732,817 bp
  • T to G, chromosome 8 at 34,838,547 bp
  • A to T, chromosome 9 at 40,101,455 bp
  • A to T, chromosome 9 at 67,362,647 bp
  • C to T, chromosome 9 at 106,033,755 bp
  • A to T, chromosome 9 at 121,712,608 bp
  • C to A, chromosome 10 at 49,535,436 bp
  • T to C, chromosome 10 at 53,349,055 bp
  • T to C, chromosome 11 at 48,801,765 bp
  • A to T, chromosome 11 at 58,156,740 bp
  • G to T, chromosome 11 at 78,190,152 bp
  • A to G, chromosome 11 at 98,718,852 bp
  • A to T, chromosome 11 at 115,022,707 bp
  • G to A, chromosome 11 at 115,871,844 bp
  • T to A, chromosome 12 at 69,585,235 bp
  • C to T, chromosome 12 at 101,893,683 bp
  • C to T, chromosome 12 at 110,666,087 bp
  • C to T, chromosome 14 at 75,713,276 bp
  • T to C, chromosome 15 at 8,649,568 bp
  • G to A, chromosome 15 at 10,589,315 bp
  • T to C, chromosome 15 at 74,574,110 bp
  • C to A, chromosome 15 at 78,994,060 bp
  • G to A, chromosome 17 at 26,654,879 bp
  • A to G, chromosome 17 at 46,129,456 bp
  • G to A, chromosome 17 at 46,263,774 bp
  • A to T, chromosome 17 at 71,709,568 bp
  • T to A, chromosome 17 at 74,027,119 bp
  • A to G, chromosome 18 at 22,523,921 bp
  • G to T, chromosome 18 at 73,781,147 bp
  • T to A, chromosome 19 at 41,629,886 bp
  • A to G, chromosome 19 at 43,798,178 bp
  • A to G, chromosome 19 at 47,098,226 bp
  • C to T, chromosome 19 at 47,268,123 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7015 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045116-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.