Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7015Btlr/Mmmh
Stock Number:
045116-MU
Citation ID:
RRID:MMRRC_045116-MU
Other Names:
R7015 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: MGluT1, Eaat1, B430115D02Rik, GLAST, Gmt1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20512
Homologene: 20882
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20562
Homologene: 2302
Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, Ankycorbin, Norpeg, 1700008J19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Eca39, BCATc, Bcat-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Zranb2
Name: zinc finger, RAN-binding domain containing 2
Synonyms: Znf265, Zis, Zfp265
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53861
Aplf
Name: aprataxin and PNKP like factor
Synonyms: 2010301N04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72103
Homologene: 49753
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 42,898,546 bp
  • A to G, chromosome 1 at 58,282,758 bp
  • G to A, chromosome 1 at 82,506,950 bp
  • A to T, chromosome 1 at 136,183,331 bp
  • A to G, chromosome 1 at 160,075,168 bp
  • A to G, chromosome 2 at 155,792,624 bp
  • A to G, chromosome 2 at 165,002,081 bp
  • C to T, chromosome 3 at 66,994,649 bp
  • A to T, chromosome 3 at 157,536,733 bp
  • T to C, chromosome 4 at 32,644,278 bp
  • A to T, chromosome 4 at 41,765,421 bp
  • A to G, chromosome 4 at 110,478,500 bp
  • G to T, chromosome 4 at 145,536,635 bp
  • A to T, chromosome 5 at 53,172,574 bp
  • A to T, chromosome 5 at 67,946,362 bp
  • A to G, chromosome 5 at 87,139,796 bp
  • G to A, chromosome 5 at 114,256,855 bp
  • T to C, chromosome 5 at 123,613,612 bp
  • G to A, chromosome 6 at 87,641,902 bp
  • T to C, chromosome 6 at 113,341,926 bp
  • T to C, chromosome 6 at 132,657,165 bp
  • G to C, chromosome 6 at 145,039,583 bp
  • C to A, chromosome 7 at 4,552,627 bp
  • T to C, chromosome 7 at 43,476,927 bp
  • T to C, chromosome 7 at 84,995,558 bp
  • C to A, chromosome 7 at 102,742,444 bp
  • T to C, chromosome 7 at 103,732,817 bp
  • T to G, chromosome 8 at 34,838,547 bp
  • A to T, chromosome 9 at 40,101,455 bp
  • A to T, chromosome 9 at 67,362,647 bp
  • C to T, chromosome 9 at 106,033,755 bp
  • A to T, chromosome 9 at 121,712,608 bp
  • C to A, chromosome 10 at 49,535,436 bp
  • T to C, chromosome 10 at 53,349,055 bp
  • T to C, chromosome 11 at 48,801,765 bp
  • A to T, chromosome 11 at 58,156,740 bp
  • G to T, chromosome 11 at 78,190,152 bp
  • A to G, chromosome 11 at 98,718,852 bp
  • A to T, chromosome 11 at 115,022,707 bp
  • G to A, chromosome 11 at 115,871,844 bp
  • T to A, chromosome 12 at 69,585,235 bp
  • C to T, chromosome 12 at 101,893,683 bp
  • C to T, chromosome 12 at 110,666,087 bp
  • C to T, chromosome 14 at 75,713,276 bp
  • T to C, chromosome 15 at 8,649,568 bp
  • G to A, chromosome 15 at 10,589,315 bp
  • T to C, chromosome 15 at 74,574,110 bp
  • C to A, chromosome 15 at 78,994,060 bp
  • G to A, chromosome 17 at 26,654,879 bp
  • A to G, chromosome 17 at 46,129,456 bp
  • G to A, chromosome 17 at 46,263,774 bp
  • A to T, chromosome 17 at 71,709,568 bp
  • T to A, chromosome 17 at 74,027,119 bp
  • A to G, chromosome 18 at 22,523,921 bp
  • G to T, chromosome 18 at 73,781,147 bp
  • T to A, chromosome 19 at 41,629,886 bp
  • A to G, chromosome 19 at 43,798,178 bp
  • A to G, chromosome 19 at 47,098,226 bp
  • C to T, chromosome 19 at 47,268,123 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7015 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045116-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.