Strain Name:
C57BL/6J-MtgxR7024Btlr/Mmmh
Stock Number:
045125-MU
Citation ID:
RRID:MMRRC_045125-MU
Other Names:
R7024 (G1)
Major Collection:

Strain Information

En1
Name: engrailed 1
Synonyms: En-1, Mo-en.1, engrailed-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13798
HGNC: HGNC:3342
Homologene: 50663
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: Hsp89, Hspca, Hsp86-1, hsp4, Hsp90
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Thoc7
Name: THO complex 7
Synonyms: 1500006O09Rik, 9230101K24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66231
VEGA: 14
Homologene: 11821
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69697
Homologene: 18966
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: Hsn2, Prkwnk1, 6430573H23Rik, EG406236
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: Wolfram syndrome 1 homolog (human), wolframin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22393
Homologene: 4380
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: Red, 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Dock6
Name: dedicator of cytokinesis 6
Synonyms: C330023D02Rik, 2410095B20Rik, 4931431C02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Brd4
Name: bromodomain containing 4
Synonyms: WI-11513, HUNK1, MCAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57261
Homologene: 136213
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Rps6kc1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: RPK118, B130003F20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320119
Homologene: 8244
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269470
Homologene: 4937
Lamb2
Name: laminin, beta 2
Synonyms: Lams, npht, Lamb-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Nhsl3
Name: NHS like 3
Synonyms: C77080
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 97130
Homologene: 45837
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Sfrp5
Name: secreted frizzled-related sequence protein 5
Synonyms: SARP3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54612
Homologene: 2268
Xpot
Name: exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms: C79645, 1110004L07Rik, EXPORTIN-T
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73192
VEGA: 10
Homologene: 38291
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, hlb381, Ras GTPase-activating protein III, GAPIII, GAPIII activator 3, scat
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19414
Homologene: 7217
Ccnb1
Name: cyclin B1
Synonyms: Ccnb1-rs13, Cycb-4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268697
HGNC: HGNC:1579
Homologene: 68982
Dync2i2
Name: dynein 2 intermediate chain 2
Synonyms: Wdr34, 3200002I06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71820
Homologene: 14156
Mavs
Name: mitochondrial antiviral signaling protein
Synonyms: IPS-1, D430028G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228607
Homologene: 17004
Optn
Name: optineurin
Synonyms: 4930441O07Rik, TFIIIA-INTP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71648
Homologene: 11085
Zfp287
Name: zinc finger protein 287
Synonyms: B230333C16Rik, SKAT-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170740
Homologene: 23244
Vav1
Name: vav 1 oncogene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22324
Homologene: 3961
Trpv2
Name: transient receptor potential cation channel, subfamily V, member 2
Synonyms: OTRPC2, Vrl1, VRL-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22368
Homologene: 7993
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629499
Homologene: 51864
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Slc21a5, Oatp1a4, Oatp2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28250
Homologene: 130782
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: Armc4, 4930463I21Rik, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Myf6
Name: myogenic factor 6
Synonyms: MRF4, bHLHc4, herculin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17878
VEGA: 10
HGNC: HGNC:7566
Homologene: 1850
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Snx15
Name: sorting nexin 15
Synonyms: 1500032B08Rik, E130013C21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69024
Homologene: 12294
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Atg2a
Name: autophagy related 2A
Synonyms: 1810013C15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329015
Homologene: 86985
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: 6430548I20Rik, Pynod, Nalp10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244202
Homologene: 18468
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Psd4
Name: pleckstrin and Sec7 domain containing 4
Synonyms: EFA6B, SEC7 homolog
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215632
Homologene: 8261
Tbc1d7
Name: TBC1 domain family, member 7
Synonyms: 2610009C09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67046
VEGA: 13
Homologene: 9538
Gfer
Name: growth factor, augmenter of liver regeneration
Synonyms: Alr, ERV1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11692
VEGA: 17
HGNC: HGNC:4236
Homologene: 55884
Sorcs2
Name: sortilin-related VPS10 domain containing receptor 2
Synonyms: VPS10 domain receptor protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81840
Homologene: 56899
Or13a19
Name: olfactory receptor family 13 subfamily A member 19
Synonyms: Olfr525, GA_x6K02T2PBJ9-42472898-42473827, MOR251-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258958
Homologene: 138321
Ino80b
Name: INO80 complex subunit B
Synonyms: HMG1YL4, Hmga1l4, 2510009I23Rik, Papa1, Znhit4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70020
Homologene: 32566
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mrp1, Abcc1a, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Or7g28
Name: olfactory receptor family 7 subfamily G member 28
Synonyms: Olfr846, MOR149-3, GA_x6K02T2PVTD-13098546-13097608
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258279
Lrrc3
Name: leucine rich repeat containing 3
Synonyms: 1300011L04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237387
Homologene: 12789
Or12e8
Name: olfactory receptor family 12 subfamily E member 8
Synonyms: MOR264-2, Olfr1120, GA_x6K02T2Q125-48849180-48850100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259031
Homologene: 72054
Esd
Name: esterase D/formylglutathione hydrolase
Synonyms: Es-10, Es10, Esd
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13885
HGNC: HGNC:3465
Homologene: 55623
Rab3gap1
Name: RAB3 GTPase activating protein subunit 1
Synonyms: p130, 1700003B17Rik, 4732493F09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226407
Homologene: 45617
Lhfpl5
Name: lipoma HMGIC fusion partner-like 5
Synonyms: 9330179O15Rik, Tmhs
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328789
Homologene: 18794
Or1o1
Name: olfactory receptor family 1 subfamily O member 1
Synonyms: Olfr107, GA_x6K02T2PSCP-1867165-1868094, MOR156-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258504
Homologene: 115498
Lpo
Name: lactoperoxidase
Synonyms: 5830499B15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76113
HGNC: HGNC:6678
Homologene: 21240
Or5g9
Name: olfactory receptor family 5 subfamily G member 9
Synonyms: GA_x6K02T2Q125-47195323-47196267, MOR175-3, Olfr1009
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258565
Homologene: 17297
Top1mt
Name: DNA topoisomerase 1, mitochondrial
Synonyms: 2900052H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72960
Homologene: 43082
S100a3
Name: S100 calcium binding protein A3
Synonyms: S100E
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20197
Homologene: 2223
2310079G19Rik
Name: RIKEN cDNA 2310079G19 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69699
Homologene: 137381
Gm2832
Name: predicted gene 2832
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100040545
Morn4
Name: MORN repeat containing 4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226123
VEGA: 19
Homologene: 16635
Ciart
Name: circadian associated repressor of transcription
Synonyms: Gm129, LOC229599
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229599
Homologene: 79670
Or1e1d-ps1
Name: olfactory receptor family 1 subfamily E member 1D, pseudogene 1
Synonyms: GA_x6K02T2P1NL-4083149-4084087, Olfr396-ps1, MOR135-19
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258208
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 120,603,322 bp
  • T to A, chromosome 1 at 127,891,098 bp
  • A to G, chromosome 1 at 190,800,210 bp
  • T to C, chromosome 2 at 5,052,837 bp
  • T to G, chromosome 2 at 24,394,543 bp
  • A to G, chromosome 2 at 30,038,266 bp
  • T to A, chromosome 2 at 85,721,608 bp
  • A to G, chromosome 2 at 87,357,722 bp
  • C to A, chromosome 2 at 131,243,131 bp
  • G to A, chromosome 2 at 157,221,263 bp
  • A to G, chromosome 3 at 59,331,701 bp
  • T to A, chromosome 3 at 90,602,440 bp
  • T to A, chromosome 3 at 95,879,080 bp
  • A to G, chromosome 3 at 100,154,997 bp
  • T to A, chromosome 4 at 129,225,408 bp
  • C to A, chromosome 5 at 36,021,261 bp
  • C to T, chromosome 5 at 36,966,950 bp
  • T to A, chromosome 5 at 43,733,929 bp
  • T to A, chromosome 6 at 32,192,269 bp
  • T to C, chromosome 6 at 83,122,325 bp
  • A to T, chromosome 6 at 119,965,726 bp
  • T to C, chromosome 6 at 141,834,708 bp
  • T to A, chromosome 7 at 108,925,198 bp
  • T to C, chromosome 7 at 140,322,846 bp
  • A to G, chromosome 8 at 3,608,242 bp
  • T to C, chromosome 8 at 13,631,826 bp
  • T to C, chromosome 9 at 19,361,283 bp
  • A to G, chromosome 9 at 21,820,370 bp
  • T to A, chromosome 9 at 105,912,475 bp
  • C to A, chromosome 9 at 108,489,488 bp
  • C to T, chromosome 10 at 77,900,991 bp
  • T to C, chromosome 10 at 107,494,529 bp
  • G to T, chromosome 10 at 121,602,399 bp
  • T to G, chromosome 10 at 128,720,487 bp
  • C to A, chromosome 11 at 62,584,461 bp
  • A to T, chromosome 11 at 62,714,938 bp
  • T to A, chromosome 11 at 73,928,506 bp
  • C to A, chromosome 11 at 87,816,443 bp
  • T to C, chromosome 12 at 110,694,112 bp
  • G to A, chromosome 12 at 111,326,085 bp
  • A to T, chromosome 13 at 43,154,735 bp
  • A to G, chromosome 13 at 96,658,910 bp
  • A to G, chromosome 13 at 100,786,380 bp
  • A to G, chromosome 14 at 13,953,528 bp
  • G to T, chromosome 14 at 32,964,626 bp
  • G to A, chromosome 14 at 41,279,739 bp
  • T to A, chromosome 14 at 74,744,662 bp
  • A to T, chromosome 15 at 47,710,991 bp
  • T to A, chromosome 15 at 75,667,448 bp
  • G to C, chromosome 16 at 14,413,383 bp
  • A to G, chromosome 16 at 88,627,220 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • C to A, chromosome 17 at 24,695,968 bp
  • A to G, chromosome 17 at 28,582,983 bp
  • T to C, chromosome 17 at 32,221,910 bp
  • T to C, chromosome 17 at 37,406,204 bp
  • C to A, chromosome 17 at 57,279,268 bp
  • A to C, chromosome 18 at 7,211,593 bp
  • A to T, chromosome 18 at 70,516,849 bp
  • T to A, chromosome 19 at 6,120,596 bp
  • G to A, chromosome 19 at 6,250,219 bp
  • C to T, chromosome 19 at 42,078,044 bp
  • T to C, chromosome 19 at 42,201,765 bp
  • A to T, chromosome 19 at 57,638,450 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7024 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045125-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.