Strain Name:
C57BL/6J-MtgxR7025Btlr/Mmmh
Stock Number:
045126-MU
Citation ID:
RRID:MMRRC_045126-MU
Other Names:
R7025 (G1)
Major Collection:

Strain Information

Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: FAK, Fadk, FRNK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, beta-MHC, MyHC-I, B-MHC, Myhcb, Myhc-b, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15950
HGNC: HGNC:5395
Homologene: 115929
Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: Gltscr1l, BC032203
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Ahcyl2
Name: S-adenosylhomocysteine hydrolase-like 2
Synonyms: 4631427C17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74340
Homologene: 69337
Kif2a
Name: kinesin family member 2A
Synonyms: Kif2, M-kinesin, Kns2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16563
HGNC: HGNC:6318
Homologene: 3320
Acot7
Name: acyl-CoA thioesterase 7
Synonyms: Bach, AU014716, 2410041A17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70025
Homologene: 15780
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Pcnt
Name: pericentrin (kendrin)
Synonyms: m239Asp, Pcnt2, m275Asp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18541
VEGA: 10
Ctnnd1
Name: catenin delta 1
Synonyms: catenin (cadherin associated protein), delta 1, P120, Catns, p120-catenin, Ctnnd
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Nop56
Name: NOP56 ribonucleoprotein
Synonyms: 56kDa with KKE/D repeat, Nol5a, 2310044F10Rik, NOP56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67134
Homologene: 4660
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 2900054P12Rik, Gcap14, 1700012P13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Npnt
Name: nephronectin
Synonyms: POEM, 1110009H02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114249
Homologene: 14138
Pfas
Name: phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Synonyms: Sofa, 4432409B16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237823
HGNC: HGNC:8863
Homologene: 5970
Magel2
Name: MAGE family member L2
Synonyms: Mage-l2, ns7, nM15, NDNL1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27385
HGNC: HGNC:6814
Homologene: 8460
Cd300lg
Name: CD300 molecule like family member G
Synonyms: D11Ertd736e, 2310016B05Rik, Clm9, nepmucin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52685
Homologene: 17059
Gask1b
Name: golgi associated kinase 1B
Synonyms: Fam198b, 2210419I08Rik, Ened, 1110032E23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68659
Homologene: 9590
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Fam219a
Name: family with sequence similarity 219, member A
Synonyms: 2310028H24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71901
Homologene: 51830
Nelfb
Name: negative elongation factor complex member B
Synonyms: Cobra1, A730008L03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58202
Homologene: 121600
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Dbr1
Name: debranching RNA lariats 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83703
Homologene: 9428
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: 4732499L03Rik, melastatin, Mlsn1, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: 4832426G23Rik, Myhs-p, Myhsp, MyHC-pn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Slc22a29
Name: solute carrier family 22. member 29
Synonyms: D630002G06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 236293
Homologene: 77136
Faap24
Name: Fanconi anemia core complex associated protein 24
Synonyms: C230052I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101831
Homologene: 17535
Cdh12
Name: cadherin 12
Synonyms: Br-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 215654
HGNC: HGNC:1751
Homologene: 37873
Nrp1
Name: neuropilin 1
Synonyms: NP-1, Npn1, NPN-1, Neuropilin-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Kprp
Name: keratinocyte expressed, proline-rich
Synonyms: 1110001M24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433619
Homologene: 54921
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik, D3Bwg1078e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Shkbp1
Name: Sh3kbp1 binding protein 1
Synonyms: B930062H15Rik, SB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 192192
Homologene: 26700
Acbd4
Name: acyl-Coenzyme A binding domain containing 4
Synonyms: 2010009P05Rik, 2010015A21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67131
Homologene: 32596
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54614
Homologene: 81828
Or4a71
Name: olfactory receptor family 4 subfamily A member 71
Synonyms: MOR231-4, Olfr1243, GA_x6K02T2Q125-50972538-50971621
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258971
Homologene: 27317
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Tnfrsf8
Name: tumor necrosis factor receptor superfamily, member 8
Synonyms: CD30
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21941
Homologene: 949
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277360
Homologene: 10821
Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Synonyms: p450c17, Cyp17, steroid 17-alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13074
HGNC: HGNC:2593
Homologene: 73875
Krt90
Name: keratin 90
Synonyms: 4732456N10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239673
Homologene: 72272
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
Nab2
Name: Ngfi-A binding protein 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17937
HGNC: HGNC:7627
Homologene: 4353
Nmur1
Name: neuromedin U receptor 1
Synonyms: FM-3, NMU1R, NmU-R, Gpr66
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14767
HGNC: HGNC:4518
Homologene: 68501
Pax5
Name: paired box 5
Synonyms: EBB-1, Pax-5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18507
HGNC: HGNC:8619
Homologene: 56419
Rpe65
Name: retinal pigment epithelium 65
Synonyms: A930029L06Rik, Mord1, rd12
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19892
Homologene: 20108
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244178
Homologene: 9700
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: 1300001I07Rik, contrapsin, Spi-2, MMCM2, MMSpi2, Spi2, RP54, alpha-1 antiproteinase, D12Rp54
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
Elk4
Name: ELK4, member of ETS oncogene family
Synonyms: Sap1, A130026I01Rik, 2310011G17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13714
HGNC: HGNC:3326
Homologene: 1492
Vmn1r44
Name: vomeronasal 1 receptor 44
Synonyms: V1rb4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113854
Homologene: 113975
Dpt
Name: dermatopontin
Synonyms: 5033416F05Rik, 1810032B19Rik, early quiescence protein-1, EQ-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56429
HGNC: HGNC:3011
Homologene: 1458
Or5d45
Name: olfactory receptor family 5 subfamily D member 45
Synonyms: Olfr1175-ps, MOR174-15P, GA_x6K02T2Q125-49808415-49807477, Olfr1175
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 546770
HGNC: HGNC:8336
Homologene: 77381
Or6c63-ps1
Name: olfactory receptor family 6 subfamily C member 63, pseudogene 1
Synonyms: EG544748, GA_x6K02T2PULF-10749079-10748573, EG546487, Olfr766, Olfr766-ps1, MOR115-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 546487
Homologene: 67771
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,369,423 bp
  • C to A, chromosome 1 at 86,387,848 bp
  • C to A, chromosome 1 at 132,019,369 bp
  • G to A, chromosome 1 at 164,796,939 bp
  • T to A, chromosome 1 at 172,284,550 bp
  • T to C, chromosome 1 at 173,928,385 bp
  • A to C, chromosome 2 at 25,210,493 bp
  • T to C, chromosome 2 at 52,296,273 bp
  • T to A, chromosome 2 at 69,483,028 bp
  • A to T, chromosome 2 at 84,610,606 bp
  • T to C, chromosome 2 at 88,323,262 bp
  • T to A, chromosome 2 at 89,527,604 bp
  • C to T, chromosome 2 at 130,277,881 bp
  • TCCGACCCC to TCCGACCCCGACCCC, chromosome 2 at 166,613,187 bp
  • T to C, chromosome 3 at 79,886,548 bp
  • T to A, chromosome 3 at 92,825,197 bp
  • G to A, chromosome 3 at 97,724,183 bp
  • C to T, chromosome 3 at 132,908,396 bp
  • A to C, chromosome 3 at 159,622,685 bp
  • T to C, chromosome 4 at 41,521,925 bp
  • G to A, chromosome 4 at 44,679,501 bp
  • C to T, chromosome 4 at 145,274,403 bp
  • T to C, chromosome 4 at 152,178,189 bp
  • C to T, chromosome 5 at 16,352,668 bp
  • C to T, chromosome 5 at 150,540,478 bp
  • T to C, chromosome 6 at 29,908,421 bp
  • A to G, chromosome 6 at 89,893,754 bp
  • T to A, chromosome 7 at 3,821,262 bp
  • T to C, chromosome 7 at 27,355,281 bp
  • A to G, chromosome 7 at 35,392,871 bp
  • A to C, chromosome 7 at 62,379,787 bp
  • A to T, chromosome 7 at 64,226,714 bp
  • A to G, chromosome 7 at 104,141,275 bp
  • C to T, chromosome 7 at 120,030,010 bp
  • G to T, chromosome 8 at 128,480,954 bp
  • A to G, chromosome 9 at 99,575,983 bp
  • G to T, chromosome 10 at 76,403,835 bp
  • T to C, chromosome 10 at 86,850,837 bp
  • T to A, chromosome 10 at 127,666,508 bp
  • T to A, chromosome 10 at 129,064,675 bp
  • A to G, chromosome 11 at 67,297,539 bp
  • A to T, chromosome 11 at 68,990,760 bp
  • A to G, chromosome 11 at 102,043,074 bp
  • T to A, chromosome 11 at 103,104,538 bp
  • A to T, chromosome 12 at 104,341,142 bp
  • A to G, chromosome 13 at 106,982,594 bp
  • T to C, chromosome 14 at 36,940,007 bp
  • C to A, chromosome 14 at 54,974,644 bp
  • C to A, chromosome 15 at 21,358,814 bp
  • G to A, chromosome 15 at 73,221,809 bp
  • C to T, chromosome 15 at 99,306,400 bp
  • T to C, chromosome 15 at 101,557,175 bp
  • T to A, chromosome 17 at 20,471,083 bp
  • T to C, chromosome 17 at 46,801,668 bp
  • A to C, chromosome 17 at 83,425,311 bp
  • G to A, chromosome 19 at 8,160,580 bp
  • A to G, chromosome 19 at 24,132,688 bp
  • T to A, chromosome 19 at 46,670,980 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7025 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045126-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.