Strain Name:
C57BL/6J-MtgxR7056Btlr/Mmmh
Stock Number:
045153-MU
Citation ID:
RRID:MMRRC_045153-MU
Other Names:
R7056 (G1)
Major Collection:

Strain Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: TonEBP, B130038B15Rik, OREBP, nfatz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra5, Acra-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Olr1
Name: oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms: LOX-1, Scare1, SR-EI
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108078
HGNC: HGNC:8133
Homologene: 1910
Rnf111
Name: ring finger 111
Synonyms: Arkadia
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93836
VEGA: 9
Homologene: 9741
Net1
Name: neuroepithelial cell transforming gene 1
Synonyms: 0610025H04Rik, Net1 homolog, mNET1, 9530071N24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56349
VEGA: 13
Homologene: 4283
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Cep97
Name: centrosomal protein 97
Synonyms: 4932439K18Rik, Lrriq2, E130116N02Rik, 2810403B08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74201
Homologene: 11579
Cop1
Name: COP1, E3 ubiquitin ligase
Synonyms: Rfwd2, Cop1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26374
Homologene: 115565
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Eed
Name: embryonic ectoderm development
Synonyms: l(7)5Rn, l7Rn5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13626
HGNC: HGNC:3188
Homologene: 2814
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: 5430435M13Rik, C130002K18Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Cog5
Name: component of oligomeric golgi complex 5
Synonyms: 5430405C01Rik, GTC90, GOLTC1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238123
VEGA: 12
Homologene: 42221
Eif3a
Name: eukaryotic translation initiation factor 3, subunit A
Synonyms: A830012B05Rik, Eif3s10, Csma, Eif3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13669
VEGA: 19
HGNC: HGNC:3271
Homologene: 2779
Zfp292
Name: zinc finger protein 292
Synonyms: Zfp-15, 5730450D02Rik, Zn-16, Zn-15, 9430062L07Rik, Zfp15, Krox-10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30046
Homologene: 8493
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
B2m
Name: beta-2 microglobulin
Synonyms: beta 2 microglobulin, beta2-m, Ly-m11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12010
HGNC: HGNC:914
Homologene: 2987
Mepce
Name: methylphosphate capping enzyme
Synonyms: D5Wsu46e, Bcdin3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231803
Homologene: 32447
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232491
Homologene: 11758
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: 9330188B09Rik, D630001M17Rik, 4921513O20Rik, LOC381026, cI-46
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: SRp75, Sfrs4, MNCb-2616, 5730499P16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57317
Homologene: 25624
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233410
Homologene: 8759
Rbm33
Name: RNA binding motif protein 33
Synonyms: 6430512A10Rik, Prr8, 3200001K10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381626
Homologene: 137386
Morc2a
Name: microrchidia 2A
Synonyms: Zcwcc1, 8430403M08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74522
Homologene: 8966
Susd4
Name: sushi domain containing 4
Synonyms: E430021N18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96935
Homologene: 23062
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103199
VEGA: 10
Homologene: 6713
Mep1b
Name: meprin 1 beta
Synonyms: meprin beta, Mep-1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: Dnahc17, 2810003K23Rik, LOC382552, Dnahcl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Wdr93
Name: WD repeat domain 93
Synonyms: EG626359
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 626359
Homologene: 56878
Dennd4a
Name: DENN domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102442
VEGA: 9
Homologene: 55933
Dner
Name: delta/notch-like EGF repeat containing
Synonyms: A930026D19Rik, BET
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227325
Homologene: 26722
Ptpdc1
Name: protein tyrosine phosphatase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218232
VEGA: 13
Homologene: 17576
Fbn2
Name: fibrillin 2
Synonyms: sy, Fib-2, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Vmn2r77
Name: vomeronasal 2, receptor 77
Synonyms: EG546983
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546983
Homologene: 115466
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72094
Homologene: 55988
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: C630029D13Rik, DGK-beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Gm13941
Name: predicted gene 13941
Type: Gene
Species: Mouse
Chromosome: 2
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: CMF608, Adlican2, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Fam234b
Name: family with sequence similarity 234, member B
Synonyms: 8430419L09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74525
Homologene: 12572
Dus1l
Name: dihydrouridine synthase 1 like
Synonyms: 1110032N12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68730
Homologene: 6569
Mgat3
Name: mannoside acetylglucosaminyltransferase 3
Synonyms: GnT-III, 1110038J12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17309
VEGA: 15
HGNC: HGNC:7046
Homologene: 31088
Gm9938
Name: predicted gene 9938
Type: Gene
Species: Mouse
Chromosome: 19
Sh3pxd2b
Name: SH3 and PX domains 2B
Synonyms: Tks4, G431001E03Rik, Fad49
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268396
Homologene: 27952
Sorcs2
Name: sortilin-related VPS10 domain containing receptor 2
Synonyms: VPS10 domain receptor protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81840
Homologene: 56899
Tmem256
Name: transmembrane protein 256
Synonyms: 3110009M16Rik, 1810027O10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69186
Homologene: 45148
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Radil
Name: Ras association and DIL domains
Synonyms: D930005D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231858
Homologene: 77648
Sel1l2
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: LOC228684
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228684
Homologene: 16802
Necab2
Name: N-terminal EF-hand calcium binding protein 2
Synonyms: Efcbp2, Necab2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 117148
Homologene: 62200
Cyp4f17
Name: cytochrome P450, family 4, subfamily f, polypeptide 17
Synonyms: EG208285
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 208285
VEGA: 17
Homologene: 129713
Zfp69
Name: zinc finger protein 69
Synonyms: KRAB2, LOC381549, Zfp63
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381549
Homologene: 45693
Or2ab1
Name: olfactory receptor family 2 subfamily AB member 1
Synonyms: MOR102-2, Olfr324, GA_x6K02T2NKPP-822947-822000
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257892
Homologene: 79395
Zswim2
Name: zinc finger SWIM-type containing 2
Synonyms: 4933437F18Rik, 1700025P14Rik, MEX
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71861
Homologene: 32689
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Pmm2
Name: phosphomannomutase 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54128
HGNC: HGNC:9115
Homologene: 257
Slc30a2
Name: solute carrier family 30 (zinc transporter), member 2
Synonyms: Znt2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230810
Homologene: 40855
Tor4a
Name: torsin family 4, member A
Synonyms: A830007P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227612
Homologene: 17140
Or4f60
Name: olfactory receptor family 4 subfamily F member 60
Synonyms: GA_x6K02T2Q125-73119859-73118924, MOR245-23, Olfr1313
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258257
Homologene: 106834
Sox18
Name: SRY (sex determining region Y)-box 18
Synonyms: Sry-related HMG-box gene 18, Ragl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20672
Homologene: 7546
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 84,580,736 bp
  • A to C, chromosome 1 at 155,848,627 bp
  • C to T, chromosome 1 at 159,250,077 bp
  • C to A, chromosome 1 at 182,833,156 bp
  • T to C, chromosome 2 at 25,194,841 bp
  • C to T, chromosome 2 at 83,920,748 bp
  • T to G, chromosome 2 at 111,096,802 bp
  • T to C, chromosome 2 at 112,072,317 bp
  • T to C, chromosome 2 at 122,150,984 bp
  • T to A, chromosome 2 at 140,245,414 bp
  • T to C, chromosome 2 at 181,671,487 bp
  • T to G, chromosome 3 at 59,331,080 bp
  • A to T, chromosome 4 at 34,809,784 bp
  • A to G, chromosome 4 at 120,931,098 bp
  • G to A, chromosome 4 at 121,049,716 bp
  • G to T, chromosome 4 at 131,900,693 bp
  • G to A, chromosome 4 at 134,347,415 bp
  • T to C, chromosome 5 at 28,394,003 bp
  • C to A, chromosome 5 at 36,068,130 bp
  • T to A, chromosome 5 at 87,337,094 bp
  • T to C, chromosome 5 at 137,782,706 bp
  • A to T, chromosome 5 at 142,494,354 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • T to C, chromosome 6 at 129,488,941 bp
  • A to G, chromosome 6 at 135,228,452 bp
  • G to T, chromosome 6 at 142,359,082 bp
  • T to C, chromosome 7 at 79,749,340 bp
  • T to A, chromosome 7 at 81,023,319 bp
  • C to T, chromosome 7 at 86,801,815 bp
  • A to T, chromosome 7 at 89,970,356 bp
  • T to C, chromosome 7 at 118,146,400 bp
  • G to A, chromosome 8 at 107,368,106 bp
  • A to G, chromosome 8 at 119,452,139 bp
  • C to T, chromosome 9 at 54,981,701 bp
  • A to G, chromosome 9 at 64,906,923 bp
  • A to T, chromosome 9 at 70,453,675 bp
  • T to A, chromosome 9 at 95,862,863 bp
  • A to G, chromosome 9 at 109,436,284 bp
  • A to T, chromosome 10 at 41,220,932 bp
  • A to G, chromosome 11 at 3,675,925 bp
  • T to C, chromosome 11 at 32,422,737 bp
  • A to G, chromosome 11 at 58,598,218 bp
  • C to A, chromosome 11 at 58,996,296 bp
  • G to T, chromosome 11 at 69,838,590 bp
  • A to G, chromosome 11 at 118,125,386 bp
  • T to C, chromosome 11 at 120,791,294 bp
  • T to C, chromosome 12 at 31,665,469 bp
  • A to C, chromosome 12 at 38,100,493 bp
  • T to C, chromosome 13 at 3,884,845 bp
  • C to A, chromosome 13 at 48,586,990 bp
  • C to T, chromosome 13 at 92,030,695 bp
  • T to A, chromosome 15 at 7,884,396 bp
  • T to G, chromosome 15 at 80,211,896 bp
  • T to A, chromosome 15 at 91,774,995 bp
  • T to A, chromosome 16 at 8,642,764 bp
  • A to G, chromosome 16 at 55,905,572 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • A to T, chromosome 17 at 32,527,872 bp
  • T to A, chromosome 18 at 21,091,190 bp
  • T to A, chromosome 18 at 58,076,726 bp
  • T to G, chromosome 19 at 23,724,617 bp
  • T to A, chromosome 19 at 60,763,062 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7056 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045153-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.