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Strain Name:
C57BL/6J-MtgxR7057Btlr/Mmmh
Stock Number:
045154-MU
Citation ID:
RRID:MMRRC_045154-MU
Other Names:
R7057 (G1)
Major Collection:

Strain Information

Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21366
Homologene: 2291
Zfp704
Name: zinc finger protein 704
Synonyms: Gig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170753
Homologene: 64370
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: 4930554K12Rik, D130072O21Rik, tankyrase 1, TANK1, mTNKS1, Parp5a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21951
Homologene: 18405
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, D14Abb1e, MommeD6, Fam208a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 4,776,642 bp
  • T to A, chromosome 1 at 65,247,205 bp
  • A to T, chromosome 1 at 88,362,080 bp
  • T to C, chromosome 1 at 93,011,996 bp
  • A to G, chromosome 1 at 185,289,367 bp
  • T to C, chromosome 1 at 195,151,610 bp
  • T to A, chromosome 2 at 26,425,265 bp
  • G to A, chromosome 2 at 31,422,649 bp
  • C to A, chromosome 2 at 68,410,127 bp
  • A to C, chromosome 2 at 89,074,464 bp
  • A to G, chromosome 2 at 107,295,320 bp
  • T to A, chromosome 2 at 127,829,527 bp
  • T to C, chromosome 3 at 9,470,917 bp
  • A to G, chromosome 3 at 94,363,493 bp
  • A to G, chromosome 3 at 103,645,980 bp
  • G to A, chromosome 4 at 88,274,105 bp
  • T to A, chromosome 4 at 127,127,886 bp
  • G to A, chromosome 4 at 134,347,415 bp
  • T to G, chromosome 4 at 156,233,917 bp
  • A to G, chromosome 5 at 34,821,723 bp
  • T to A, chromosome 5 at 110,188,663 bp
  • A to C, chromosome 5 at 118,054,960 bp
  • G to A, chromosome 5 at 143,173,927 bp
  • T to A, chromosome 6 at 40,968,247 bp
  • A to C, chromosome 6 at 91,741,267 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • A to T, chromosome 7 at 10,901,709 bp
  • T to C, chromosome 8 at 34,840,014 bp
  • T to C, chromosome 8 at 64,101,881 bp
  • A to G, chromosome 8 at 92,831,705 bp
  • T to C, chromosome 8 at 119,876,797 bp
  • A to G, chromosome 9 at 7,357,840 bp
  • G to A, chromosome 9 at 7,369,173 bp
  • A to G, chromosome 9 at 18,646,079 bp
  • A to T, chromosome 9 at 38,581,754 bp
  • A to T, chromosome 9 at 50,998,561 bp
  • C to A, chromosome 9 at 87,705,264 bp
  • T to A, chromosome 9 at 96,825,050 bp
  • T to C, chromosome 10 at 13,180,902 bp
  • T to G, chromosome 10 at 56,388,033 bp
  • T to C, chromosome 10 at 121,804,953 bp
  • A to G, chromosome 11 at 4,144,586 bp
  • G to T, chromosome 11 at 5,282,442 bp
  • A to T, chromosome 11 at 34,227,684 bp
  • T to C, chromosome 11 at 34,695,217 bp
  • A to C, chromosome 11 at 73,787,148 bp
  • A to C, chromosome 12 at 11,242,418 bp
  • T to C, chromosome 12 at 87,127,378 bp
  • C to T, chromosome 13 at 30,947,550 bp
  • A to T, chromosome 14 at 27,461,651 bp
  • T to C, chromosome 14 at 44,722,024 bp
  • C to A, chromosome 14 at 115,133,242 bp
  • C to A, chromosome 15 at 73,587,638 bp
  • T to A, chromosome 15 at 100,682,893 bp
  • G to T, chromosome 17 at 25,721,126 bp
  • T to C, chromosome 17 at 28,638,397 bp
  • A to T, chromosome 17 at 31,648,857 bp
  • A to T, chromosome 17 at 44,814,537 bp
  • CCATGATGGCGGC to CC, chromosome 17 at 50,293,406 bp
  • G to A, chromosome 17 at 79,335,523 bp
  • A to T, chromosome 17 at 81,649,095 bp
  • T to A, chromosome 18 at 52,332,108 bp
  • G to T, chromosome 19 at 11,526,889 bp
  • A to T, chromosome 19 at 12,884,642 bp
  • G to T, chromosome 19 at 13,502,879 bp
  • T to C, chromosome 19 at 36,118,233 bp
  • A to G, chromosome 19 at 39,807,619 bp
  • G to T, chromosome 19 at 58,676,263 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7057 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045154-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.