Strain Name:
C57BL/6J-MtgxR7057Btlr/Mmmh
Stock Number:
045154-MU
Citation ID:
RRID:MMRRC_045154-MU
Other Names:
R7057 (G1)
Major Collection:

Strain Information

Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21366
Homologene: 2291
Zfp704
Name: zinc finger protein 704
Synonyms: Gig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170753
Homologene: 64370
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: D130072O21Rik, Parp5a, 4930554K12Rik, mTNKS1, TANK1, tankyrase 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21951
Homologene: 18405
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Tasor
Name: transcription activation suppressor
Synonyms: Fam208a, D14Abb1e, 4933409E02Rik, MommeD6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Slc45a4
Name: solute carrier family 45, member 4
Synonyms: 9330175B01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106068
Homologene: 69908
Stk39
Name: serine/threonine kinase 39
Synonyms: SPAK, DCHT, RF005, Rnl5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53416
Homologene: 22739
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, PipkIII, 5230400C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381314
Homologene: 7118
Mmp2
Name: matrix metallopeptidase 2
Synonyms: Clg4a, MMP-2, GelA, 72kDa type IV collagenase, gelatinase A, 72kDa gelatinase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17390
HGNC: HGNC:7166
Homologene: 3329
Golga3
Name: golgin A3
Synonyms: 5430416E01Rik, G1-499-14, repro27, Mea-2, Mea2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Mrpl15
Name: mitochondrial ribosomal protein L15
Synonyms: HSPC145, Rpml7, MRP-L7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27395
Homologene: 32210
Runx2
Name: runt related transcription factor 2
Synonyms: AML3, PEBP2aA, Pebpa2a, Osf2, Cbfa1, PEBP2 alpha A, polyomavirus enhancer binding factor 2 (PEBP2), SL3-3 enhancer factor 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Pxylp1
Name: 2-phosphoxylose phosphatase 1
Synonyms: C130099A20Rik, Acpl2, 9430094M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235534
Homologene: 15931
Ms4a6b
Name: membrane-spanning 4-domains, subfamily A, member 6B
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69774
Homologene: 128306
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Htt
Name: huntingtin
Synonyms: HD, IT15, C430023I11Rik, htt, Hdh, huntingtin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
U2af1
Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
Synonyms: 2010107D16Rik, 35kDa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108121
VEGA: 17
Homologene: 14345
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Znrf3
Name: zinc and ring finger 3
Synonyms: LOC382477
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 407821
Homologene: 46592
Atg4a-ps
Name: autophagy related 4A, pseudogene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 102926
Gja1
Name: gap junction protein, alpha 1
Synonyms: Cnx43, connexin43, connexin 43, Gja-1, Cx43, alpha 1 connexin, Cx43alpha1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14609
VEGA: 10
HGNC: HGNC:4274
Homologene: 136
Kcna4
Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Synonyms: Kv1.4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16492
HGNC: HGNC:6222
Homologene: 20514
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: CED-5, MBC, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Chtf18
Name: CTF18, chromosome transmission fidelity factor 18
Synonyms: CTF18, 6030457M03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214901
Homologene: 32532
Or5b120
Name: olfactory receptor family 5 subfamily B member 120
Synonyms: GA_x6K02T2RE5P-3834960-3835907, Olfr1477, MOR202-10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258691
Homologene: 110492
Mmp12
Name: matrix metallopeptidase 12
Synonyms: MMP12, macrophage elastase, Mmel
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17381
HGNC: HGNC:7158
Homologene: 20547
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117600
Homologene: 56898
Dazl
Name: deleted in azoospermia-like
Synonyms: Tpx-2, Tpx2, Dazla, Daz-like
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13164
VEGA: 17
Homologene: 86954
Sik2
Name: salt inducible kinase 2
Synonyms: Snf1lk2, G630080D20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235344
Homologene: 22875
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: D930008O12Rik, Ncx1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Or1e30
Name: olfactory receptor family 1 subfamily E member 30
Synonyms: MOR135-26, Olfr390, GA_x6K02T2P1NL-3938806-3939741
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258344
Homologene: 115483
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57782
Homologene: 23287
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Tbx18
Name: T-box18
Synonyms: 2810012F10Rik, 2810404D13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76365
Homologene: 11384
Tesc
Name: tescalcin
Synonyms: TE-1, 1010001A17Rik, 2410011K10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57816
Homologene: 75158
Ankrd1
Name: ankyrin repeat domain 1
Synonyms: MARP1, CARP, Crap, Alrp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107765
VEGA: 19
Homologene: 8289
Aqp12
Name: aquaporin 12
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208760
Homologene: 45582
Cyp2c40
Name: cytochrome P450, family 2, subfamily c, polypeptide 40
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13099
Homologene: 74936
Ccdc157
Name: coiled-coil domain containing 157
Synonyms: 4930562D19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216516
Homologene: 72271
Ltv1
Name: LTV1 ribosome biogenesis factor
Synonyms: 2610020N02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353258
VEGA: 10
Homologene: 6338
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Cr2
Name: complement receptor 2
Synonyms: CD35, Cr-2, Cr1, C3DR, CD21, Cr-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Or4c114
Name: olfactory receptor family 4 subfamily C member 114
Synonyms: MOR233-6, GA_x6K02T2Q125-50555603-50554668, Olfr1219
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258901
Homologene: 27292
Klhl36
Name: kelch-like 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234796
Homologene: 32598
Or5b12b
Name: olfactory receptor family 5 subfamily B member 12B
Synonyms: GA_x6K02T2RE5P-3213352-3214296, MOR202-7, Olfr1445
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258694
Homologene: 133606
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Zscan4b
Name: zinc finger and SCAN domain containing 4B
Synonyms: EG665780
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665780
Homologene: 85986
Tmem35b
Name: transmembrane protein 35B
Synonyms: Zmym6nb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039968
Homologene: 106612
Or8b48
Name: olfactory receptor family 8 subfamily B member 48
Synonyms: MOR165-4, GA_x6K02T2PVTD-32283590-32284522, Olfr912
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258806
VEGA: 9
Homologene: 115510
Slc26a8
Name: solute carrier family 26, member 8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224661
Homologene: 27095
Hus1b
Name: HUS1 checkpoint clamp component B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210554
Homologene: 51833
Pnlip
Name: pancreatic lipase
Synonyms: 1810007A24Rik, PTL, pancreatic triglyceride lipase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69060
VEGA: 19
HGNC: HGNC:9155
Homologene: 30999
Slc30a2
Name: solute carrier family 30 (zinc transporter), member 2
Synonyms: Znt2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230810
Homologene: 40855
Cdc42ep3
Name: CDC42 effector protein 3
Synonyms: Borg2, 3200001F04Rik, UB1, Cep3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 260409
VEGA: 17
Homologene: 4708
1810009J06Rik
Name: RIKEN cDNA 1810009J06 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73626
Homologene: 117995
Cela1
Name: chymotrypsin-like elastase family, member 1
Synonyms: Ela-1, 1810062B19Rik, Ela1, PC-TsF, 1810009A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109901
VEGA: 15
HGNC: HGNC:3308
Homologene: 20454
C2cd4d
Name: C2 calcium-dependent domain containing 4D
Synonyms: LOC271944, Gm659
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271944
Homologene: 86310
Gm8267
Name: predicted gene 8267
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 666744
Homologene: 115686
Ftmt
Name: ferritin mitochondrial
Synonyms: MtF, mitochondrial ferritin, Fth3, 4930447C24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67634
VEGA: 18
Homologene: 110661
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 4,776,642 bp
  • T to A, chromosome 1 at 65,247,205 bp
  • A to T, chromosome 1 at 88,362,080 bp
  • T to C, chromosome 1 at 93,011,996 bp
  • A to G, chromosome 1 at 185,289,367 bp
  • T to C, chromosome 1 at 195,151,610 bp
  • T to A, chromosome 2 at 26,425,265 bp
  • G to A, chromosome 2 at 31,422,649 bp
  • C to A, chromosome 2 at 68,410,127 bp
  • A to C, chromosome 2 at 89,074,464 bp
  • A to G, chromosome 2 at 107,295,320 bp
  • T to A, chromosome 2 at 127,829,527 bp
  • T to C, chromosome 3 at 9,470,917 bp
  • A to G, chromosome 3 at 94,363,493 bp
  • A to G, chromosome 3 at 103,645,980 bp
  • G to A, chromosome 4 at 88,274,105 bp
  • T to A, chromosome 4 at 127,127,886 bp
  • G to A, chromosome 4 at 134,347,415 bp
  • T to G, chromosome 4 at 156,233,917 bp
  • A to G, chromosome 5 at 34,821,723 bp
  • T to A, chromosome 5 at 110,188,663 bp
  • A to C, chromosome 5 at 118,054,960 bp
  • G to A, chromosome 5 at 143,173,927 bp
  • T to A, chromosome 6 at 40,968,247 bp
  • A to C, chromosome 6 at 91,741,267 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • A to T, chromosome 7 at 10,901,709 bp
  • T to C, chromosome 8 at 34,840,014 bp
  • T to C, chromosome 8 at 64,101,881 bp
  • A to G, chromosome 8 at 92,831,705 bp
  • T to C, chromosome 8 at 119,876,797 bp
  • A to G, chromosome 9 at 7,357,840 bp
  • G to A, chromosome 9 at 7,369,173 bp
  • A to G, chromosome 9 at 18,646,079 bp
  • A to T, chromosome 9 at 38,581,754 bp
  • A to T, chromosome 9 at 50,998,561 bp
  • C to A, chromosome 9 at 87,705,264 bp
  • T to A, chromosome 9 at 96,825,050 bp
  • T to C, chromosome 10 at 13,180,902 bp
  • T to G, chromosome 10 at 56,388,033 bp
  • T to C, chromosome 10 at 121,804,953 bp
  • A to G, chromosome 11 at 4,144,586 bp
  • G to T, chromosome 11 at 5,282,442 bp
  • A to T, chromosome 11 at 34,227,684 bp
  • T to C, chromosome 11 at 34,695,217 bp
  • A to C, chromosome 11 at 73,787,148 bp
  • A to C, chromosome 12 at 11,242,418 bp
  • T to C, chromosome 12 at 87,127,378 bp
  • C to T, chromosome 13 at 30,947,550 bp
  • A to T, chromosome 14 at 27,461,651 bp
  • T to C, chromosome 14 at 44,722,024 bp
  • C to A, chromosome 14 at 115,133,242 bp
  • C to A, chromosome 15 at 73,587,638 bp
  • T to A, chromosome 15 at 100,682,893 bp
  • G to T, chromosome 17 at 25,721,126 bp
  • T to C, chromosome 17 at 28,638,397 bp
  • A to T, chromosome 17 at 31,648,857 bp
  • A to T, chromosome 17 at 44,814,537 bp
  • CCATGATGGCGGC to CC, chromosome 17 at 50,293,406 bp
  • G to A, chromosome 17 at 79,335,523 bp
  • A to T, chromosome 17 at 81,649,095 bp
  • T to A, chromosome 18 at 52,332,108 bp
  • G to T, chromosome 19 at 11,526,889 bp
  • A to T, chromosome 19 at 12,884,642 bp
  • G to T, chromosome 19 at 13,502,879 bp
  • T to C, chromosome 19 at 36,118,233 bp
  • A to G, chromosome 19 at 39,807,619 bp
  • G to T, chromosome 19 at 58,676,263 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7057 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045154-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.