Strain Name:
C57BL/6J-MtgxR7059Btlr/Mmmh
Stock Number:
045156-MU
Citation ID:
RRID:MMRRC_045156-MU
Other Names:
R7059 (G1)
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Kcns2
Name: K+ voltage-gated channel, subfamily S, 2
Synonyms: E130006J24Rik, Kv9.2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16539
VEGA: 15
HGNC: HGNC:6301
Homologene: 22465
Atl3
Name: atlastin GTPase 3
Synonyms: 5730596K20Rik, 4633402C03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109168
VEGA: 19
Homologene: 9149
Mrpl18
Name: mitochondrial ribosomal protein L18
Synonyms: MRP-L18, 1010001C05Rik, HSPC071
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67681
Homologene: 8566
Olfm1
Name: olfactomedin 1
Synonyms: Noelin 1, Pancortin 1-4, Noelin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56177
Homologene: 8612
Kat8
Name: K(lysine) acetyltransferase 8
Synonyms: 5830450F21Rik, MOF, Myst1, D7Ertd629e, 2010203C02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67773
Homologene: 41676
Cul3
Name: cullin 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26554
HGNC: HGNC:2553
Homologene: 2661
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Kcnk1
Name: potassium channel, subfamily K, member 1
Synonyms: TWIK-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16525
HGNC: HGNC:6272
Homologene: 1691
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: Wbp12, Bat2, D17H6S51E, G2, 3110039B05Rik, Bat-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53761
Homologene: 10567
Rab5c
Name: RAB5C, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19345
HGNC: HGNC:9785
Homologene: 55533
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 2A-HUB, 6430549P11Rik, 2310047C04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224170
Homologene: 8771
Hgfac
Name: hepatocyte growth factor activator
Synonyms: HGFA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54426
HGNC: HGNC:4894
Homologene: 1170
Fcrl2
Name: Fc receptor like 2
Synonyms: Msr2, Fcrls, Fcrh2, IFGP2, 2810439C17Rik, moFcRH2sc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80891
Homologene: 57117
Mapk9
Name: mitogen-activated protein kinase 9
Synonyms: JNK/SAPK alpha, c-Jun N-terminal kinase, JNK2, Prkm9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26420
HGNC: HGNC:6886
Homologene: 55685
Btbd10
Name: BTB domain containing 10
Synonyms: Gmrp1, 1110056N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68815
Homologene: 13009
Rbm48
Name: RNA binding motif protein 48
Synonyms: C030048B08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269623
Homologene: 12944
Abca16
Name: ATP-binding cassette, sub-family A member 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233810
Homologene: 132942
Atp6v1c2
Name: ATPase, H+ transporting, lysosomal V1 subunit C2
Synonyms: 1110038G14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68775
Homologene: 15866
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, Hek, Hek4, Mek4, End3, Cek4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Myl3
Name: myosin, light polypeptide 3
Synonyms: ventricular, MLC1v, Mylc, slow skeletal, alkali, MLC1s
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17897
HGNC: HGNC:7584
Homologene: 20099
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: SNAT4, Ata3, 1110012E16Rik, 1700012A18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69354
VEGA: 15
Homologene: 75077
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Brd10
Name: bromodomain containing 10
Synonyms: Gm9832, 9930021J03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240613
Homologene: 19046
Kif1a
Name: kinesin family member 1A
Synonyms: LOC381283, N-3 kinesin, C630002N23Rik, ATSV, Kns1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Mtpap
Name: mitochondrial poly(A) polymerase
Synonyms: Tent6, Papd1, 0610027A18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67440
VEGA: 18
Homologene: 10008
Chmp6
Name: charged multivesicular body protein 6
Synonyms: chromatin modifying protein 6, 2400004G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208092
Homologene: 11607
Slc36a1
Name: solute carrier family 36 (proton/amino acid symporter), member 1
Synonyms: 5830411H19Rik, Pat1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215335
Homologene: 121860
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide, Intin1, Itih-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Gpr39
Name: G protein-coupled receptor 39
Synonyms: 4933415E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71111
HGNC: HGNC:4496
Homologene: 20380
Rxfp1
Name: relaxin/insulin-like family peptide receptor 1
Synonyms: LOC381489, Lgr7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381489
Homologene: 11007
Zswim8
Name: zinc finger SWIM-type containing 8
Synonyms: 4832404P21Rik, 2310021P13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268721
VEGA: 14
Homologene: 34313
Myrfl
Name: myelin regulatory factor-like
Synonyms: LOC237558, Gm239
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237558
VEGA: 10
Homologene: 88588
Adcyap1r1
Name: adenylate cyclase activating polypeptide 1 receptor 1
Synonyms: 2900024I10Rik, PAC1R, PACAP1-R, PAC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11517
HGNC: HGNC:242
Homologene: 870
Colq
Name: collagen like tail subunit of asymmetric acetylcholinesterase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 382864
HGNC: HGNC:2226
Lcn2
Name: lipocalin 2
Synonyms: neu-related lipocalin, 24p3, NGAL, NRL
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16819
HGNC: HGNC:6526
Homologene: 4064
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: Hgfl, D9H3F15S2, DNF15S2h, D3F15S2h
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15235
Homologene: 7360
9430097D07Rik
Name: RIKEN cDNA 9430097D07 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319245
VEGA: 2
Fbxw17
Name: F-box and WD-40 domain protein 17
Synonyms: 1110064L07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109082
Homologene: 82571
Bcl2a1b
Name: B cell leukemia/lymphoma 2 related protein A1b
Synonyms: A1-b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12045
HGNC: HGNC:991
Homologene: 2988
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93838
Homologene: 14143
Cpox
Name: coproporphyrinogen oxidase
Synonyms: clone 560, Cpo, nct, cac, M100835
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12892
VEGA: 16
HGNC: HGNC:2321
Homologene: 76
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 80721
Homologene: 23530
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: 2310081N20Rik, acid ceramidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Esp36
Name: exocrine gland secreted peptide 36
Synonyms: Gm20408
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126765
Abraxas1
Name: BRCA1 A complex subunit
Synonyms: Ccdc98, 3830405G04Rik, 5630400M01Rik, Fam175a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70681
Homologene: 16376
Mzf1
Name: myeloid zinc finger 1
Synonyms: Zfp121, Mzf2, Znf42, Zfp98
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109889
Homologene: 9633
Or52e8
Name: olfactory receptor family 52 subfamily E member 8
Synonyms: GA_x6K02T2PBJ9-7604826-7603885, Olfr671, MOR32-12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257910
Homologene: 133595
Lrfn1
Name: leucine rich repeat and fibronectin type III domain containing 1
Synonyms: SALM2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80749
Homologene: 12729
Aqp5
Name: aquaporin 5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11830
VEGA: 15
HGNC: HGNC:638
Homologene: 20398
Gm8126
Name: predicted gene 8126
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108168152
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 80,276,424 bp
  • T to A, chromosome 1 at 83,022,369 bp
  • C to T, chromosome 1 at 93,046,829 bp
  • C to A, chromosome 1 at 125,677,959 bp
  • T to C, chromosome 2 at 28,222,616 bp
  • T to A, chromosome 2 at 32,387,596 bp
  • T to C, chromosome 2 at 32,574,497 bp
  • T to A, chromosome 2 at 112,352,912 bp
  • A to T, chromosome 3 at 79,652,269 bp
  • A to T, chromosome 3 at 87,257,340 bp
  • CGG to CG, chromosome 4 at 141,918,291 bp
  • A to T, chromosome 5 at 3,590,625 bp
  • T to A, chromosome 5 at 35,044,429 bp
  • T to C, chromosome 5 at 100,806,237 bp
  • T to A, chromosome 6 at 55,491,310 bp
  • C to T, chromosome 6 at 83,064,809 bp
  • G to T, chromosome 7 at 13,053,058 bp
  • T to C, chromosome 7 at 28,466,930 bp
  • A to T, chromosome 7 at 104,976,017 bp
  • C to T, chromosome 7 at 113,329,922 bp
  • A to G, chromosome 7 at 120,421,748 bp
  • A to G, chromosome 7 at 127,924,903 bp
  • C to A, chromosome 8 at 33,574,730 bp
  • A to T, chromosome 8 at 41,347,069 bp
  • T to A, chromosome 8 at 126,029,727 bp
  • T to A, chromosome 9 at 89,199,760 bp
  • C to A, chromosome 9 at 108,084,064 bp
  • C to T, chromosome 9 at 110,742,037 bp
  • A to T, chromosome 10 at 5,346,859 bp
  • T to C, chromosome 10 at 116,849,206 bp
  • T to C, chromosome 11 at 49,867,047 bp
  • A to G, chromosome 11 at 55,223,672 bp
  • G to A, chromosome 11 at 100,719,963 bp
  • T to C, chromosome 11 at 119,916,040 bp
  • C to A, chromosome 12 at 17,289,004 bp
  • T to C, chromosome 12 at 51,888,234 bp
  • T to A, chromosome 13 at 50,432,548 bp
  • T to C, chromosome 13 at 111,772,778 bp
  • G to T, chromosome 14 at 20,714,573 bp
  • G to A, chromosome 14 at 30,931,309 bp
  • C to A, chromosome 14 at 31,526,034 bp
  • T to A, chromosome 14 at 43,261,518 bp
  • A to T, chromosome 15 at 34,838,835 bp
  • G to T, chromosome 15 at 97,009,014 bp
  • A to T, chromosome 15 at 99,594,246 bp
  • A to G, chromosome 16 at 48,980,942 bp
  • T to A, chromosome 16 at 58,670,927 bp
  • T to A, chromosome 16 at 63,568,455 bp
  • A to G, chromosome 17 at 12,913,781 bp
  • G to A, chromosome 17 at 35,157,388 bp
  • A to T, chromosome 17 at 38,417,051 bp
  • T to C, chromosome 18 at 4,396,202 bp
  • A to G, chromosome 19 at 7,533,968 bp
  • A to C, chromosome 19 at 7,533,969 bp
  • T to A, chromosome 19 at 29,719,545 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7059 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045156-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.