Strain Name:
C57BL/6J-MtgxR7063Btlr/Mmmh
Stock Number:
045159-MU
Citation ID:
RRID:MMRRC_045159-MU
Other Names:
R7063 (G1)
Major Collection:

Strain Information

Ubald2
Name: UBA-like domain containing 2
Synonyms: D030012E24Rik, Fam100b, 1110014K08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319370
Homologene: 100077
Zfp7
Name: zinc finger protein 7
Synonyms: KRAB20, Zfp-7, Zfp86-rs1, mszf73-2, Krox-2, Zfp80, KRAB7, Zfp65
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223669
VEGA: 15
Homologene: 20729
Cwf19l2
Name: CWF19 like cell cycle control factor 2
Synonyms: 3230401L03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244672
Homologene: 12366
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: Brunol2, CUG-BP, D2Wsu101e, Cugbp1, 1600010O03Rik, CUG-BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Arhgap35
Name: Rho GTPase activating protein 35
Synonyms: Grlf1, p190RhoGAP, p190A, P190 RhoGAP, 6430596G11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232906
HGNC: HGNC:4591
Homologene: 35136
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Spt16, Fact140, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98956
Homologene: 6785
Casr
Name: calcium-sensing receptor
Synonyms: CaR, Gprc2a, cation sensing receptor
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Chst2
Name: carbohydrate sulfotransferase 2
Synonyms: N-acetylglucosamine-6-O-sulfotransferase, GST-2, C130041E03Rik, Gn6st
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54371
HGNC: HGNC:1970
Homologene: 3150
Gpr89
Name: G protein-coupled receptor 89
Synonyms: SH120, 4933412D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67549
Homologene: 9475
Lclat1
Name: lysocardiolipin acyltransferase 1
Synonyms: Lycat, AGPAT8, ALCAT1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225010
Homologene: 33167
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243407
Homologene: 135976
Cyp2r1
Name: cytochrome P450, family 2, subfamily r, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244209
Homologene: 75210
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: IDPm, Idh-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Vav1
Name: vav 1 oncogene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22324
Homologene: 3961
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Man1a
Name: mannosidase 1, alpha
Synonyms: PCR1, mannosyl-oligosaccharide alpha-1,2-mannosidase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17155
HGNC: HGNC:6821
Homologene: 4316
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Glp1r
Name: glucagon-like peptide 1 receptor
Synonyms: GLP1Rc, GLP-1R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14652
VEGA: 17
HGNC: HGNC:4324
Homologene: 1558
Serpina3m
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3M
Synonyms: MMCM7, Spi-2l, contrapsin-like, Spi2-rs1, alpha-1 antiproteinase, 3e46, antitrypsin, Spi-2rs1, Spi2.4, MMSPi2.4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20717
HGNC: HGNC:16
Homologene: 111129
Sypl2
Name: synaptophysin like 2
Synonyms: Mg29
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17306
Homologene: 7421
Gbp4
Name: guanylate binding protein 4
Synonyms: Mpa-2, Mpa2, Mag-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17472
Homologene: 128731
Lgmn
Name: legumain
Synonyms: preprolegumain, Prsc1, AEP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Or10d3
Name: olfactory receptor family 10 subfamily D member 3
Synonyms: MOR224-9, Olfr958, GA_x6K02T2PVTD-33247839-33246901
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258327
VEGA: 9
HGNC: HGNC:8168
Homologene: 27128
Or5b12b
Name: olfactory receptor family 5 subfamily B member 12B
Synonyms: GA_x6K02T2RE5P-3213352-3214296, MOR202-7, Olfr1445
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258694
Homologene: 133606
Vmn1r7
Name: vomeronasal 1 receptor 7
Synonyms: V1rc31, Gm5568
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434016
Homologene: 83427
Or10v5
Name: olfactory receptor family 10 subfamily V member 5
Synonyms: Olfr1417, MOR266-2, GA_x6K02T2RE5P-2172809-2171862
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258938
Homologene: 27304
Btbd6
Name: BTB domain containing 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399566
VEGA: 12
Homologene: 41967
Vmn1r191
Name: vomeronasal 1 receptor 191
Synonyms: V1rh15
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 632534
Homologene: 110880
Or5p55
Name: olfactory receptor family 5 subfamily P member 55
Synonyms: Olfr476, MOR204-3, GA_x6K02T2PBJ9-10296787-10297719
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258926
Eepd1
Name: endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms: 2310005P05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67484
Homologene: 12144
Vstm5
Name: V-set and transmembrane domain containing 5
Synonyms: 2200002K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69137
VEGA: 9
Homologene: 45982
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 278279
Homologene: 25521
Vgll2
Name: vestigial like family member 2
Synonyms: Vgl-2, C130057C21Rik, VITO-1, Vito1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215031
Homologene: 35066
Pcmtd2
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Synonyms: 5330414D10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245867
Homologene: 10099
Gm6408
Name: predicted gene 6408
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 623198
Homologene: 86127
Potefam3f
Name: POTE ankyrin domain family member 3F
Synonyms: Pote3f, Gm31371
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78672
Homologene: 128726
Zmat2
Name: zinc finger, matrin type 2
Synonyms: 2900082I05Rik, 2610510D14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66492
VEGA: 18
Homologene: 5563
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 91,012,844 bp
  • G to A, chromosome 2 at 103,748,077 bp
  • T to A, chromosome 2 at 181,854,983 bp
  • C to G, chromosome 3 at 96,875,698 bp
  • A to T, chromosome 3 at 108,217,655 bp
  • T to A, chromosome 3 at 144,755,206 bp
  • G to A, chromosome 5 at 105,118,448 bp
  • A to G, chromosome 5 at 109,363,784 bp
  • T to C, chromosome 5 at 146,483,784 bp
  • T to A, chromosome 6 at 57,024,433 bp
  • A to G, chromosome 6 at 65,441,403 bp
  • A to G, chromosome 7 at 16,565,113 bp
  • A to G, chromosome 7 at 80,095,684 bp
  • C to A, chromosome 7 at 107,968,204 bp
  • A to G, chromosome 7 at 114,552,949 bp
  • G to A, chromosome 8 at 19,903,412 bp
  • C to T, chromosome 8 at 45,040,775 bp
  • A to G, chromosome 9 at 3,430,532 bp
  • A to G, chromosome 9 at 15,239,253 bp
  • A to G, chromosome 9 at 25,483,036 bp
  • T to G, chromosome 9 at 39,550,115 bp
  • G to T, chromosome 9 at 95,405,568 bp
  • T to C, chromosome 10 at 52,027,976 bp
  • G to T, chromosome 10 at 54,030,744 bp
  • A to T, chromosome 10 at 105,348,525 bp
  • T to C, chromosome 10 at 115,456,734 bp
  • A to G, chromosome 11 at 116,434,617 bp
  • A to G, chromosome 12 at 102,402,678 bp
  • A to T, chromosome 12 at 104,391,467 bp
  • A to G, chromosome 12 at 112,977,512 bp
  • A to G, chromosome 12 at 117,689,129 bp
  • C to T, chromosome 13 at 22,178,694 bp
  • T to C, chromosome 14 at 52,172,048 bp
  • A to G, chromosome 15 at 28,233,248 bp
  • A to G, chromosome 15 at 76,891,719 bp
  • T to C, chromosome 16 at 36,494,574 bp
  • T to C, chromosome 17 at 20,481,148 bp
  • A to G, chromosome 17 at 30,925,558 bp
  • C to T, chromosome 17 at 57,311,860 bp
  • A to G, chromosome 17 at 73,239,991 bp
  • A to G, chromosome 18 at 36,796,574 bp
  • A to G, chromosome 19 at 11,828,184 bp
  • A to G, chromosome 19 at 12,884,085 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7063 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045159-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.