Strain Name:
C57BL/6J-MtgxR7065Btlr/Mmmh
Stock Number:
045161-MU
Citation ID:
RRID:MMRRC_045161-MU
Other Names:
R7065 (G1)
Major Collection:

Strain Information

Pax3
Name: paired box 3
Synonyms: Splchl2, Pax-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18505
HGNC: HGNC:8617
Homologene: 22494
Gpm6a
Name: glycoprotein m6a
Synonyms: M6A, Gpm6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234267
HGNC: HGNC:4460
Homologene: 3864
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Chmp4b
Name: charged multivesicular body protein 4B
Synonyms: Snf7-2, 2010012F05Rik, chromatin modifying protein 4B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75608
Homologene: 57102
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77683
Homologene: 11698
Ctnna1
Name: catenin alpha 1
Synonyms: 2010010M04Rik, Catna1, catenin (cadherin associated protein), alpha 1, alpha(E)-catenin, alpha E catenin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12385
VEGA: 18
HGNC: HGNC:2509
Homologene: 1433
Fryl
Name: FRY like transcription coactivator
Synonyms: 9030227G01Rik, 2310004H21Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Gk5
Name: glycerol kinase 5
Synonyms: G630067D24Rik, C330018K18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235533
Homologene: 15141
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67958
Homologene: 13964
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfp406, LOC380993, Zfat1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Kif1b
Name: kinesin family member 1B
Synonyms: N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, A530096N05Rik, Kif1b alpha, Kif1b beta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Cep57
Name: centrosomal protein 57
Synonyms: 4931428M20Rik, 3110002L15Rik, Tsp57, 4921510P06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74360
Homologene: 8790
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4-2, Nedd4b, 1300012C07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A630086M08Rik, Rbm16, A930036P18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: 1300006C19Rik, Simp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Unc5a
Name: unc-5 netrin receptor A
Synonyms: Unc5h1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107448
Homologene: 41474
Raver1
Name: ribonucleoprotein, PTB-binding 1
Synonyms: 1300006N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71766
VEGA: 9
Homologene: 12410
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, Zfp650, 1110059H15Rik, A130030D10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Cdan1
Name: codanin 1
Synonyms: CDA1, codanin-1, CDA-I, 1500015A01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Clec14a
Name: C-type lectin domain family 14, member a
Synonyms: 1200003C23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66864
VEGA: 12
Homologene: 12047
Grik4
Name: glutamate receptor, ionotropic, kainate 4
Synonyms: 6330551K01Rik, KA1, GluRgamma1, KA-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110637
HGNC: HGNC:4582
Homologene: 81829
Zfy1
Name: zinc finger protein 1, Y-linked
Synonyms: Zfy-1
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 22767
Homologene: 56456
Gclm
Name: glutamate-cysteine ligase, modifier subunit
Synonyms: Glclr, Gcmc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14630
HGNC: HGNC:4312
Homologene: 1557
Zfp874a
Name: zinc finger protein 874a
Synonyms: Zfp874, C330011K17Rik, Rslcan15
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238692
Homologene: 135597
Opn4
Name: opsin 4 (melanopsin)
Synonyms: 1110007J02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30044
VEGA: 14
Homologene: 69152
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: 3632410F03Rik, pcy, D330020E01Rik, nephrocystin 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, calcium release channel isoform 1, Ryr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Or5ak24
Name: olfactory receptor family 5 subfamily AK member 24
Synonyms: MOR203-4, GA_x6K02T2Q125-46907515-46906571, Olfr994
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258425
Homologene: 17245
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: Megf7, mdig, 6430526J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: A930002K18Rik, 4930505G06Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Lipe
Name: lipase, hormone sensitive
Synonyms: 4933403G17Rik, HSL
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Frmd4a
Name: FERM domain containing 4A
Synonyms: Gm13190, C230040M21Rik, 2700017I06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Pigs
Name: phosphatidylinositol glycan anchor biosynthesis, class S
Synonyms: LOC276846, LOC245087
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276846
Homologene: 41963
Klk1b11
Name: kallikrein 1-related peptidase b11
Synonyms: mGK-11, Klk11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16613
Homologene: 68141
Ankmy2
Name: ankyrin repeat and MYND domain containing 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217473
VEGA: 12
Homologene: 10662
Spice1
Name: spindle and centriole associated protein 1
Synonyms: Ccdc52, D16Ertd480e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212514
Homologene: 16931
Niban1
Name: niban apoptosis regulator 1
Synonyms: Fam129a, Niban
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63913
Homologene: 62170
Cfh
Name: complement component factor h
Synonyms: Sas1, Sas-1, Mud-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Grip2
Name: glutamate receptor interacting protein 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243547
Homologene: 16327
Pla2g5
Name: phospholipase A2, group V
Synonyms: sPLA2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18784
HGNC: HGNC:9038
Homologene: 716
Or5p78
Name: olfactory receptor family 5 subfamily P member 78
Synonyms: Olfr506, MOR204-23, GA_x6K02T2PBJ9-10942040-10942984
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258215
Homologene: 133672
Or5al6
Name: olfactory receptor family 5 subfamily AL member 6
Synonyms: MOR185-12, Olfr1040, GA_x6K02T2Q125-47615732-47614791
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404323
Homologene: 79382
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: ADAM3, tMDC, Cyrn1, Taz83, Taz83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Semp2l2b
Name: SUMO/sentrin specific peptidase 2-like 2B
Synonyms: 4930444G20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114671
Homologene: 130042
Ncoa4
Name: nuclear receptor coactivator 4
Synonyms: 4432406M01Rik, 1110034E15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27057
HGNC: HGNC:7671
Homologene: 38052
Ifi44l
Name: interferon-induced protein 44 like
Synonyms: H-28, NS1178, H28
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15061
Homologene: 48468
Or4c11c
Name: olfactory receptor family 4 subfamily C member 11C
Synonyms: Olfr1203, MOR230-1, Olfr1205, GA_x6K02T2Q125-50336588-50337313, GA_x6K02T2Q125-50304328-50305251, MOR230-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258898
Homologene: 81567
Ppt2
Name: palmitoyl-protein thioesterase 2
Synonyms: 0610007M19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54397
HGNC: HGNC:9326
Homologene: 10448
Speer4d
Name: spermatogenesis associated glutamate (E)-rich protein 4D
Synonyms: SPEER-4D
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 360220
Homologene: 69402
Pdzk1
Name: PDZ domain containing 1
Synonyms: 4921513F16Rik, mPDZK1, 1700023D20Rik, Nherf3, 2610507N21Rik, D3Ertd537e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59020
Homologene: 1964
Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Synonyms: Cyp2e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13106
HGNC: HGNC:2631
Homologene: 68089
Cflar
Name: CASP8 and FADD-like apoptosis regulator
Synonyms: Cash, c-Flip, Flip, 2310024N18Rik, A430105C05Rik, Casper
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12633
HGNC: HGNC:1876
Homologene: 7652
Mterf4
Name: mitochondrial transcription termination factor 4
Synonyms: 4933412H03Rik, 1810059A23Rik, Mterfd2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69821
Homologene: 45600
Pcdha12
Name: protocadherin alpha 12
Synonyms: Crnr5, Pcdha13, Cnr5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192164
HGNC: HGNC:8667
Homologene: 135870
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 58,731,209 bp
  • T to C, chromosome 1 at 78,194,011 bp
  • T to A, chromosome 1 at 93,304,895 bp
  • T to A, chromosome 1 at 140,086,402 bp
  • A to G, chromosome 1 at 151,700,107 bp
  • G to A, chromosome 2 at 4,566,112 bp
  • T to C, chromosome 2 at 24,840,697 bp
  • A to C, chromosome 2 at 65,464,855 bp
  • A to G, chromosome 2 at 69,953,705 bp
  • A to G, chromosome 2 at 76,798,112 bp
  • A to G, chromosome 2 at 85,430,179 bp
  • A to C, chromosome 2 at 86,146,001 bp
  • A to T, chromosome 2 at 88,831,386 bp
  • A to T, chromosome 2 at 91,155,057 bp
  • A to G, chromosome 2 at 91,511,580 bp
  • A to G, chromosome 2 at 120,718,921 bp
  • A to G, chromosome 2 at 154,691,242 bp
  • A to G, chromosome 3 at 96,868,432 bp
  • A to G, chromosome 3 at 122,262,671 bp
  • A to G, chromosome 3 at 151,759,792 bp
  • G to T, chromosome 4 at 53,074,233 bp
  • C to A, chromosome 4 at 138,800,604 bp
  • T to C, chromosome 4 at 149,202,525 bp
  • A to C, chromosome 5 at 15,620,423 bp
  • T to C, chromosome 5 at 73,090,756 bp
  • T to G, chromosome 6 at 73,087,562 bp
  • C to A, chromosome 6 at 91,783,569 bp
  • T to C, chromosome 6 at 136,720,766 bp
  • A to G, chromosome 7 at 25,385,178 bp
  • T to C, chromosome 7 at 29,103,643 bp
  • A to G, chromosome 7 at 43,998,962 bp
  • G to A, chromosome 7 at 108,613,059 bp
  • T to A, chromosome 7 at 140,763,993 bp
  • A to G, chromosome 8 at 24,711,675 bp
  • C to A, chromosome 8 at 55,037,458 bp
  • C to A, chromosome 8 at 128,460,712 bp
  • T to C, chromosome 9 at 13,818,381 bp
  • T to C, chromosome 9 at 21,090,294 bp
  • A to C, chromosome 9 at 42,543,831 bp
  • T to C, chromosome 9 at 95,485,659 bp
  • A to G, chromosome 9 at 96,179,056 bp
  • A to G, chromosome 9 at 104,041,990 bp
  • A to G, chromosome 9 at 115,266,156 bp
  • T to C, chromosome 10 at 22,067,298 bp
  • T to A, chromosome 11 at 9,292,595 bp
  • T to A, chromosome 11 at 78,336,739 bp
  • T to C, chromosome 11 at 83,016,968 bp
  • T to A, chromosome 12 at 8,952,472 bp
  • G to A, chromosome 12 at 36,187,708 bp
  • A to G, chromosome 12 at 58,268,794 bp
  • A to T, chromosome 13 at 54,991,083 bp
  • A to T, chromosome 13 at 67,442,282 bp
  • T to A, chromosome 14 at 32,172,900 bp
  • C to A, chromosome 14 at 34,595,877 bp
  • T to C, chromosome 14 at 52,141,193 bp
  • T to C, chromosome 15 at 68,181,120 bp
  • T to A, chromosome 16 at 44,355,535 bp
  • G to A, chromosome 17 at 3,159,211 bp
  • T to A, chromosome 17 at 24,327,751 bp
  • A to G, chromosome 17 at 34,622,855 bp
  • A to T, chromosome 18 at 35,152,616 bp
  • A to G, chromosome 18 at 37,021,626 bp
  • A to G, chromosome 18 at 65,195,969 bp
  • A to G, chromosome Y at 725,428 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7065 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045161-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.