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Strain Name:
C57BL/6J-MtgxR7067Btlr/Mmmh
Stock Number:
045163-MU
Citation ID:
RRID:MMRRC_045163-MU
Other Names:
R7067 (G1)
Major Collection:

Strain Information

Tlx3
Name: T cell leukemia, homeobox 3
Synonyms: Tlx1l2, Rnx, Hox11l2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27140
Homologene: 23181
Efemp1
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216616
HGNC: HGNC:3218
Homologene: 3028
Ccn2
Name: cellular communication network factor 2
Synonyms: Hcs24, hypertrophic chondrocyte-specific gene product 24, Fisp12, Ccn2, Ctgf
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14219
HGNC: HGNC:2500
Homologene: 1431
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 66,646,572 bp
  • C to T, chromosome 1 at 93,874,725 bp
  • A to T, chromosome 1 at 151,183,490 bp
  • A to G, chromosome 1 at 162,320,971 bp
  • C to T, chromosome 2 at 24,277,529 bp
  • A to T, chromosome 2 at 39,047,719 bp
  • T to A, chromosome 2 at 82,980,734 bp
  • T to A, chromosome 2 at 86,314,567 bp
  • G to C, chromosome 3 at 30,751,123 bp
  • C to T, chromosome 3 at 37,431,698 bp
  • A to G, chromosome 3 at 90,260,182 bp
  • G to A, chromosome 3 at 131,293,553 bp
  • A to G, chromosome 3 at 145,988,264 bp
  • T to C, chromosome 4 at 128,747,141 bp
  • T to A, chromosome 4 at 134,344,218 bp
  • T to A, chromosome 4 at 136,241,362 bp
  • C to T, chromosome 4 at 136,327,393 bp
  • G to T, chromosome 5 at 9,266,295 bp
  • A to G, chromosome 5 at 33,214,614 bp
  • A to G, chromosome 5 at 52,862,235 bp
  • A to G, chromosome 5 at 62,654,044 bp
  • A to G, chromosome 5 at 67,400,268 bp
  • G to T, chromosome 5 at 110,334,218 bp
  • A to G, chromosome 5 at 120,605,147 bp
  • A to T, chromosome 6 at 37,957,840 bp
  • T to A, chromosome 6 at 48,597,916 bp
  • A to T, chromosome 6 at 112,757,305 bp
  • T to C, chromosome 7 at 4,543,076 bp
  • T to A, chromosome 7 at 13,131,922 bp
  • T to C, chromosome 7 at 14,333,054 bp
  • A to T, chromosome 7 at 16,429,051 bp
  • T to A, chromosome 7 at 29,908,646 bp
  • T to C, chromosome 7 at 42,764,878 bp
  • T to A, chromosome 7 at 45,415,624 bp
  • T to C, chromosome 7 at 46,018,690 bp
  • T to C, chromosome 7 at 81,317,326 bp
  • T to C, chromosome 7 at 127,800,716 bp
  • C to T, chromosome 8 at 25,033,701 bp
  • A to G, chromosome 8 at 26,979,016 bp
  • T to A, chromosome 9 at 18,658,251 bp
  • T to C, chromosome 9 at 40,804,625 bp
  • A to T, chromosome 9 at 61,924,989 bp
  • T to A, chromosome 9 at 95,969,512 bp
  • A to G, chromosome 10 at 5,234,586 bp
  • A to G, chromosome 10 at 24,596,975 bp
  • A to G, chromosome 10 at 84,440,294 bp
  • T to A, chromosome 11 at 5,524,275 bp
  • A to G, chromosome 11 at 5,866,431 bp
  • A to G, chromosome 11 at 9,291,845 bp
  • A to T, chromosome 11 at 28,867,926 bp
  • C to T, chromosome 11 at 33,203,204 bp
  • A to G, chromosome 11 at 35,508,230 bp
  • G to T, chromosome 11 at 99,317,383 bp
  • T to C, chromosome 12 at 8,009,423 bp
  • T to C, chromosome 15 at 4,900,504 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • A to T, chromosome 15 at 78,292,494 bp
  • T to A, chromosome 16 at 19,699,663 bp
  • T to A, chromosome 16 at 91,056,033 bp
  • G to A, chromosome 17 at 30,982,272 bp
  • G to A, chromosome 17 at 35,011,479 bp
  • A to C, chromosome 17 at 71,244,858 bp
  • G to A, chromosome 18 at 70,509,417 bp
  • G to A, chromosome 19 at 55,304,439 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7067 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045163-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.