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Strain Name:
C57BL/6J-MtgxR7084Btlr/Mmmh
Stock Number:
045178-MU
Citation ID:
RRID:MMRRC_045178-MU
Other Names:
R7084 (G1)
Major Collection:

Strain Information

Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Abce1
Name: ATP-binding cassette, sub-family E member 1
Synonyms: RNS4l (Eye), Oabp, Rnaseli
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24015
HGNC: HGNC:69
Homologene: 2205
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Zfp638
Name: zinc finger protein 638
Synonyms: Np220, Zfml
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18139
Homologene: 7447
Lin9
Name: lin-9 DREAM MuvB core complex component
Synonyms: 2700022J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72568
Homologene: 35252
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75956
Znrf1
Name: zinc and ring finger 1
Synonyms: nin283, Rnf42, Zrfp1, B830022L21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170737
Homologene: 41858
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 9,566,805 bp
  • A to T, chromosome 1 at 75,487,750 bp
  • T to A, chromosome 1 at 80,503,856 bp
  • A to T, chromosome 1 at 120,063,271 bp
  • A to G, chromosome 1 at 132,570,509 bp
  • T to C, chromosome 1 at 165,604,698 bp
  • C to A, chromosome 1 at 180,688,096 bp
  • G to T, chromosome 2 at 21,212,330 bp
  • G to A, chromosome 2 at 24,293,670 bp
  • T to C, chromosome 2 at 76,768,364 bp
  • C to T, chromosome 2 at 76,919,345 bp
  • C to T, chromosome 2 at 84,773,491 bp
  • C to T, chromosome 2 at 127,510,936 bp
  • G to T, chromosome 2 at 127,708,873 bp
  • A to T, chromosome 2 at 165,398,037 bp
  • T to C, chromosome 3 at 63,328,217 bp
  • T to C, chromosome 3 at 75,139,546 bp
  • T to C, chromosome 3 at 82,012,011 bp
  • T to C, chromosome 3 at 99,939,270 bp
  • T to A, chromosome 3 at 104,784,960 bp
  • A to G, chromosome 4 at 3,172,134 bp
  • A to T, chromosome 4 at 98,771,345 bp
  • T to A, chromosome 4 at 140,741,558 bp
  • C to T, chromosome 4 at 154,986,991 bp
  • T to C, chromosome 5 at 25,021,969 bp
  • T to A, chromosome 5 at 66,295,421 bp
  • A to T, chromosome 5 at 86,492,200 bp
  • G to A, chromosome 5 at 122,369,560 bp
  • T to C, chromosome 6 at 18,226,138 bp
  • C to A, chromosome 6 at 29,535,877 bp
  • T to C, chromosome 6 at 55,278,235 bp
  • T to A, chromosome 6 at 83,066,455 bp
  • T to A, chromosome 6 at 83,953,126 bp
  • C to A, chromosome 6 at 129,766,710 bp
  • T to C, chromosome 7 at 4,924,330 bp
  • T to A, chromosome 7 at 16,145,038 bp
  • T to A, chromosome 7 at 24,105,261 bp
  • C to A, chromosome 7 at 29,172,998 bp
  • C to T, chromosome 7 at 44,139,486 bp
  • T to A, chromosome 7 at 46,298,566 bp
  • G to A, chromosome 7 at 142,303,872 bp
  • A to T, chromosome 8 at 69,823,606 bp
  • T to C, chromosome 8 at 70,779,473 bp
  • A to T, chromosome 8 at 77,665,105 bp
  • T to A, chromosome 8 at 79,699,414 bp
  • G to T, chromosome 8 at 84,251,079 bp
  • T to C, chromosome 8 at 111,537,142 bp
  • G to T, chromosome 9 at 7,113,214 bp
  • G to A, chromosome 9 at 38,665,269 bp
  • T to C, chromosome 9 at 43,128,893 bp
  • A to G, chromosome 9 at 70,337,801 bp
  • T to C, chromosome 9 at 76,230,660 bp
  • A to G, chromosome 9 at 109,404,223 bp
  • A to G, chromosome 10 at 26,872,738 bp
  • T to C, chromosome 10 at 80,808,576 bp
  • T to A, chromosome 10 at 129,111,547 bp
  • G to T, chromosome 11 at 29,825,009 bp
  • A to G, chromosome 11 at 100,421,303 bp
  • T to C, chromosome 11 at 101,034,042 bp
  • T to A, chromosome 11 at 110,301,545 bp
  • A to T, chromosome 12 at 8,009,591 bp
  • AT to A, chromosome 12 at 83,537,797 bp
  • C to A, chromosome 12 at 84,868,685 bp
  • C to G, chromosome 13 at 21,423,130 bp
  • A to C, chromosome 13 at 48,498,863 bp
  • A to T, chromosome 13 at 93,940,616 bp
  • A to T, chromosome 13 at 119,488,185 bp
  • T to A, chromosome 14 at 66,308,822 bp
  • T to A, chromosome 14 at 77,029,656 bp
  • T to A, chromosome 14 at 98,994,224 bp
  • T to A, chromosome 15 at 75,910,381 bp
  • C to T, chromosome 17 at 8,941,162 bp
  • T to A, chromosome 17 at 23,820,316 bp
  • T to C, chromosome 17 at 28,067,021 bp
  • T to A, chromosome 17 at 31,106,131 bp
  • T to C, chromosome 17 at 46,430,790 bp
  • A to T, chromosome 17 at 78,810,563 bp
  • T to A, chromosome 18 at 36,961,562 bp
  • G to A, chromosome 19 at 8,965,414 bp
  • A to C, chromosome 19 at 12,680,834 bp
  • A to G, chromosome 19 at 29,286,398 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7084 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045178-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.