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Strain Name:
C57BL/6J-MtgxR7092Btlr/Mmmh
Stock Number:
045186-MU
Citation ID:
RRID:MMRRC_045186-MU
Other Names:
R7092 (G1)
Major Collection:

Strain Information

Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: Fadk, FAK, FRNK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Odc1
Name: ornithine decarboxylase, structural 1
Synonyms: ODC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18263
VEGA: 12
HGNC: HGNC:8109
Homologene: 1906
Pdgfc
Name: platelet-derived growth factor, C polypeptide
Synonyms: 1110064L01Rik, PDGF-C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54635
HGNC: HGNC:8801
Homologene: 9423
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108096
Homologene: 56603
Gng3
Name: guanine nucleotide binding protein (G protein), gamma 3
Synonyms: 83
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14704
VEGA: 19
HGNC: HGNC:4405
Homologene: 22575
Pde1b
Name: phosphodiesterase 1B, Ca2+-calmodulin dependent
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18574
VEGA: 15
HGNC: HGNC:8775
Homologene: 37370
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,153,676 bp
  • A to G, chromosome 1 at 91,421,431 bp
  • A to G, chromosome 1 at 128,252,222 bp
  • G to T, chromosome 1 at 132,067,663 bp
  • A to T, chromosome 1 at 150,604,246 bp
  • G to A, chromosome 1 at 171,214,178 bp
  • A to G, chromosome 1 at 171,777,189 bp
  • T to A, chromosome 2 at 37,146,611 bp
  • A to G, chromosome 2 at 73,273,771 bp
  • T to C, chromosome 2 at 76,903,416 bp
  • A to T, chromosome 2 at 85,868,607 bp
  • A to G, chromosome 2 at 102,450,756 bp
  • A to T, chromosome 2 at 132,381,316 bp
  • A to G, chromosome 2 at 152,915,190 bp
  • T to A, chromosome 2 at 177,475,292 bp
  • T to A, chromosome 3 at 28,914,547 bp
  • T to A, chromosome 3 at 40,902,374 bp
  • T to C, chromosome 3 at 59,861,079 bp
  • C to T, chromosome 3 at 81,204,352 bp
  • C to G, chromosome 3 at 122,138,569 bp
  • C to T, chromosome 3 at 138,183,745 bp
  • T to C, chromosome 3 at 142,729,795 bp
  • C to T, chromosome 3 at 159,615,591 bp
  • A to T, chromosome 4 at 41,301,366 bp
  • G to A, chromosome 4 at 43,004,831 bp
  • G to A, chromosome 4 at 102,601,851 bp
  • C to T, chromosome 4 at 152,114,508 bp
  • T to A, chromosome 4 at 153,960,994 bp
  • T to A, chromosome 5 at 74,536,843 bp
  • T to G, chromosome 5 at 145,220,089 bp
  • A to C, chromosome 6 at 18,071,819 bp
  • T to C, chromosome 6 at 42,364,245 bp
  • T to C, chromosome 6 at 89,869,903 bp
  • T to C, chromosome 6 at 92,189,626 bp
  • C to A, chromosome 6 at 116,651,788 bp
  • T to A, chromosome 6 at 129,323,000 bp
  • T to A, chromosome 6 at 142,248,675 bp
  • C to A, chromosome 7 at 4,580,861 bp
  • A to G, chromosome 7 at 48,198,236 bp
  • A to T, chromosome 7 at 100,371,822 bp
  • A to T, chromosome 7 at 105,734,109 bp
  • C to A, chromosome 7 at 118,735,271 bp
  • G to A, chromosome 7 at 140,652,237 bp
  • C to A, chromosome 7 at 141,068,636 bp
  • T to C, chromosome 7 at 141,809,648 bp
  • G to C, chromosome 7 at 141,809,687 bp
  • C to T, chromosome 8 at 65,001,048 bp
  • T to A, chromosome 8 at 71,492,265 bp
  • T to C, chromosome 8 at 72,747,870 bp
  • G to T, chromosome 8 at 105,945,223 bp
  • A to T, chromosome 8 at 109,682,596 bp
  • T to A, chromosome 8 at 110,715,496 bp
  • T to G, chromosome 8 at 122,427,698 bp
  • T to A, chromosome 9 at 7,386,981 bp
  • G to A, chromosome 9 at 18,816,057 bp
  • T to C, chromosome 9 at 74,210,472 bp
  • A to G, chromosome 9 at 78,470,673 bp
  • G to A, chromosome 9 at 103,281,043 bp
  • C to A, chromosome 9 at 108,068,600 bp
  • T to A, chromosome 9 at 123,183,613 bp
  • C to A, chromosome 10 at 62,578,300 bp
  • T to C, chromosome 10 at 117,790,494 bp
  • T to C, chromosome 11 at 30,137,119 bp
  • T to A, chromosome 11 at 80,120,720 bp
  • T to G, chromosome 11 at 84,008,857 bp
  • C to A, chromosome 11 at 96,772,839 bp
  • A to C, chromosome 11 at 120,820,120 bp
  • G to A, chromosome 12 at 17,548,313 bp
  • C to A, chromosome 12 at 72,463,464 bp
  • A to C, chromosome 13 at 53,110,236 bp
  • A to G, chromosome 14 at 36,940,655 bp
  • A to G, chromosome 14 at 67,707,351 bp
  • C to A, chromosome 15 at 4,934,678 bp
  • T to C, chromosome 15 at 35,640,634 bp
  • T to A, chromosome 15 at 63,825,098 bp
  • T to C, chromosome 15 at 64,871,770 bp
  • G to A, chromosome 15 at 73,221,809 bp
  • G to T, chromosome 15 at 103,527,031 bp
  • A to G, chromosome 16 at 44,299,829 bp
  • T to A, chromosome 16 at 73,956,643 bp
  • C to T, chromosome 17 at 8,172,970 bp
  • T to A, chromosome 17 at 20,481,076 bp
  • G to A, chromosome 17 at 55,993,876 bp
  • T to C, chromosome 17 at 56,002,954 bp
  • C to T, chromosome 17 at 74,646,745 bp
  • T to C, chromosome 19 at 4,623,090 bp
  • T to A, chromosome 19 at 8,838,247 bp
  • T to C, chromosome 19 at 33,613,692 bp
  • C to T, chromosome 19 at 34,121,358 bp
  • T to C, chromosome 19 at 43,441,948 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7092 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045186-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.