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Strain Name:
C57BL/6J-MtgxR7096Btlr/Mmmh
Stock Number:
045188-MU
Citation ID:
RRID:MMRRC_045188-MU
Other Names:
R7096 (G1)
Major Collection:

Strain Information

Alg10
Name: ALG10 alpha-1,2-glucosyltransferase
Synonyms: Deaf1, LOC380959, nse5, Alg10b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380959
VEGA: 15
Homologene: 6030
Lcat
Name: lecithin cholesterol acyltransferase
Synonyms: D8Wsu61e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16816
HGNC: HGNC:6522
Homologene: 68042
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66011
Homologene: 36409
Elovl6
Name: ELOVL fatty acid elongase 6
Synonyms: FEN1/Elo2, SUR4/Elo3-like, LCE, ELOVL family member 6, elongation of long chain fatty acids (yeast)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170439
Homologene: 11456
Cdkn2c
Name: cyclin dependent kinase inhibitor 2C
Synonyms: p18, INK4c, p18INK4c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12580
HGNC: HGNC:1789
Homologene: 966
Barhl1
Name: BarH like homeobox 1
Synonyms: Dres115, MBH2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54422
HGNC: HGNC:953
Homologene: 81871
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: aldosterone synthase, Cyp11b-2, Cyp11b, steroid-11-beta-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 37,840,614 bp
  • T to C, chromosome 1 at 53,483,440 bp
  • T to G, chromosome 1 at 58,903,590 bp
  • T to G, chromosome 2 at 28,909,714 bp
  • A to G, chromosome 2 at 127,428,289 bp
  • A to G, chromosome 2 at 151,667,920 bp
  • T to G, chromosome 3 at 40,933,870 bp
  • T to C, chromosome 3 at 75,081,737 bp
  • C to T, chromosome 3 at 86,793,259 bp
  • A to G, chromosome 3 at 129,605,106 bp
  • C to T, chromosome 4 at 109,661,358 bp
  • C to T, chromosome 4 at 128,462,726 bp
  • T to C, chromosome 4 at 140,800,124 bp
  • A to T, chromosome 5 at 3,891,769 bp
  • A to G, chromosome 5 at 64,953,776 bp
  • G to A, chromosome 5 at 92,033,184 bp
  • A to G, chromosome 5 at 100,663,720 bp
  • C to A, chromosome 5 at 118,721,926 bp
  • C to T, chromosome 5 at 124,129,261 bp
  • C to A, chromosome 5 at 128,774,269 bp
  • C to A, chromosome 6 at 42,249,473 bp
  • T to C, chromosome 6 at 136,728,341 bp
  • A to G, chromosome 6 at 142,501,373 bp
  • G to T, chromosome 7 at 4,474,191 bp
  • T to C, chromosome 7 at 4,775,996 bp
  • G to T, chromosome 7 at 35,487,589 bp
  • G to A, chromosome 7 at 41,481,443 bp
  • T to A, chromosome 7 at 92,591,832 bp
  • C to A, chromosome 7 at 108,159,641 bp
  • T to C, chromosome 7 at 125,696,559 bp
  • C to A, chromosome 8 at 27,473,567 bp
  • T to A, chromosome 8 at 105,698,489 bp
  • C to T, chromosome 8 at 105,939,677 bp
  • C to A, chromosome 8 at 119,566,325 bp
  • T to C, chromosome 8 at 125,671,923 bp
  • T to A, chromosome 9 at 14,736,816 bp
  • T to A, chromosome 9 at 119,428,189 bp
  • A to T, chromosome 10 at 23,920,911 bp
  • T to C, chromosome 10 at 127,184,028 bp
  • T to C, chromosome 10 at 129,093,846 bp
  • G to A, chromosome 11 at 29,154,867 bp
  • T to C, chromosome 11 at 33,474,896 bp
  • G to A, chromosome 11 at 69,825,690 bp
  • T to A, chromosome 11 at 73,589,637 bp
  • C to A, chromosome 11 at 74,392,231 bp
  • T to C, chromosome 11 at 80,189,225 bp
  • T to A, chromosome 11 at 114,987,495 bp
  • T to A, chromosome 11 at 115,891,498 bp
  • T to C, chromosome 12 at 84,361,821 bp
  • C to A, chromosome 12 at 110,657,078 bp
  • A to G, chromosome 13 at 23,035,026 bp
  • A to G, chromosome 13 at 119,650,893 bp
  • T to A, chromosome 15 at 74,855,988 bp
  • T to C, chromosome 15 at 82,405,261 bp
  • C to A, chromosome 15 at 88,713,935 bp
  • C to T, chromosome 15 at 90,227,361 bp
  • C to A, chromosome 15 at 92,397,503 bp
  • T to A, chromosome 15 at 102,937,038 bp
  • A to G, chromosome 16 at 14,707,164 bp
  • G to A, chromosome 16 at 87,719,291 bp
  • A to G, chromosome 17 at 20,462,500 bp
  • T to A, chromosome 17 at 23,734,113 bp
  • T to A, chromosome 17 at 34,841,470 bp
  • T to A, chromosome 18 at 34,315,957 bp
  • T to A, chromosome 18 at 35,715,425 bp
  • A to G, chromosome 18 at 69,940,170 bp
  • A to G, chromosome 18 at 73,794,890 bp
  • T to A, chromosome 19 at 5,046,680 bp
  • G to A, chromosome 19 at 5,672,615 bp
  • C to T, chromosome 19 at 7,021,810 bp
  • A to T, chromosome 19 at 8,947,775 bp
  • C to A, chromosome 19 at 37,936,200 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7096 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045188-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.