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Strain Name:
C57BL/6J-MtgxR7134Btlr/Mmmh
Stock Number:
045219-MU
Citation ID:
RRID:MMRRC_045219-MU
Other Names:
R7134 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57138
Homologene: 10665
Nap1l1
Name: nucleosome assembly protein 1-like 1
Synonyms: D10Ertd68e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 53605
VEGA: 10
HGNC: HGNC:7637
Homologene: 129218
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Rps6ka1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: Rsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20111
Homologene: 55703
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235626
Homologene: 56493
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 36,351,767 bp
  • T to A, chromosome 1 at 74,554,503 bp
  • C to T, chromosome 1 at 74,926,633 bp
  • G to T, chromosome 1 at 82,234,116 bp
  • A to C, chromosome 1 at 93,603,459 bp
  • A to G, chromosome 2 at 26,014,962 bp
  • C to A, chromosome 2 at 30,878,473 bp
  • T to C, chromosome 2 at 32,686,629 bp
  • A to G, chromosome 2 at 76,878,679 bp
  • A to T, chromosome 2 at 90,464,478 bp
  • A to T, chromosome 2 at 125,382,049 bp
  • A to G, chromosome 2 at 158,138,892 bp
  • A to T, chromosome 2 at 164,974,958 bp
  • T to C, chromosome 2 at 181,187,730 bp
  • T to C, chromosome 3 at 41,753,777 bp
  • C to T, chromosome 3 at 59,093,759 bp
  • A to T, chromosome 3 at 96,855,930 bp
  • A to T, chromosome 3 at 109,935,129 bp
  • T to C, chromosome 3 at 155,091,483 bp
  • T to C, chromosome 4 at 22,486,874 bp
  • T to A, chromosome 4 at 106,720,594 bp
  • T to C, chromosome 4 at 133,872,062 bp
  • T to A, chromosome 4 at 145,622,805 bp
  • C to T, chromosome 5 at 11,597,739 bp
  • T to A, chromosome 5 at 34,118,996 bp
  • C to T, chromosome 5 at 87,460,576 bp
  • G to A, chromosome 5 at 90,232,314 bp
  • T to C, chromosome 5 at 90,285,523 bp
  • C to T, chromosome 5 at 114,953,387 bp
  • T to C, chromosome 5 at 116,051,370 bp
  • T to A, chromosome 5 at 137,564,500 bp
  • T to C, chromosome 5 at 142,485,549 bp
  • C to T, chromosome 6 at 52,204,043 bp
  • T to C, chromosome 6 at 92,201,627 bp
  • A to T, chromosome 6 at 119,926,428 bp
  • A to G, chromosome 7 at 3,700,641 bp
  • A to G, chromosome 7 at 44,585,735 bp
  • G to A, chromosome 7 at 86,395,544 bp
  • A to G, chromosome 7 at 108,159,676 bp
  • A to G, chromosome 7 at 109,765,488 bp
  • A to T, chromosome 7 at 141,857,654 bp
  • A to T, chromosome 8 at 79,992,513 bp
  • A to T, chromosome 8 at 94,479,722 bp
  • A to T, chromosome 9 at 8,103,382 bp
  • A to G, chromosome 9 at 38,026,499 bp
  • T to C, chromosome 9 at 64,235,339 bp
  • T to A, chromosome 9 at 108,573,365 bp
  • C to T, chromosome 9 at 110,548,797 bp
  • T to C, chromosome 10 at 62,591,855 bp
  • A to T, chromosome 10 at 63,024,589 bp
  • A to G, chromosome 10 at 76,468,191 bp
  • T to C, chromosome 10 at 79,865,703 bp
  • G to A, chromosome 10 at 111,494,794 bp
  • A to T, chromosome 11 at 5,061,106 bp
  • T to A, chromosome 11 at 34,310,363 bp
  • A to T, chromosome 11 at 43,245,464 bp
  • T to C, chromosome 11 at 50,152,692 bp
  • A to G, chromosome 11 at 105,408,676 bp
  • A to T, chromosome 11 at 120,385,788 bp
  • G to T, chromosome 12 at 21,265,963 bp
  • C to T, chromosome 12 at 72,566,976 bp
  • C to T, chromosome 12 at 79,062,616 bp
  • C to T, chromosome 12 at 108,506,551 bp
  • T to G, chromosome 12 at 113,545,035 bp
  • C to T, chromosome 13 at 53,146,706 bp
  • A to G, chromosome 13 at 119,394,662 bp
  • A to T, chromosome 14 at 21,677,061 bp
  • C to T, chromosome 14 at 57,275,499 bp
  • T to G, chromosome 14 at 70,467,199 bp
  • T to G, chromosome 15 at 55,558,565 bp
  • C to T, chromosome 16 at 20,681,502 bp
  • A to G, chromosome 16 at 22,929,257 bp
  • T to C, chromosome 16 at 26,371,626 bp
  • T to C, chromosome 16 at 49,081,342 bp
  • A to T, chromosome 17 at 19,677,487 bp
  • T to A, chromosome 17 at 24,594,112 bp
  • A to T, chromosome 17 at 25,962,116 bp
  • T to C, chromosome 17 at 26,960,011 bp
  • G to A, chromosome 17 at 27,702,733 bp
  • A to G, chromosome 17 at 35,959,252 bp
  • T to C, chromosome 17 at 36,031,817 bp
  • T to A, chromosome 17 at 37,498,885 bp
  • A to G, chromosome 18 at 5,116,080 bp
  • A to G, chromosome 18 at 23,957,065 bp
  • T to A, chromosome 18 at 78,859,519 bp
  • A to T, chromosome 19 at 6,965,330 bp
  • A to T, chromosome Y at 725,788 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7134 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045219-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.