Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7162Btlr/Mmmh
Stock Number:
045261-MU
Citation ID:
RRID:MMRRC_045261-MU
Other Names:
R7162 (G1)
Major Collection:

Strain Information

Notch3
Name: notch 3
Synonyms: hpbk, N3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Gli1
Name: GLI-Kruppel family member GLI1
Synonyms: Zfp-5, Zfp5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14632
VEGA: 10
HGNC: HGNC:4317
Homologene: 3859
Il21r
Name: interleukin 21 receptor
Synonyms: NILR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60504
HGNC: HGNC:6006
Homologene: 11040
Clybl
Name: citrate lyase beta like
Synonyms: Clb, 2310014M14Rik, 0610033J05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69634
VEGA: 14
Homologene: 49925
Pcf11
Name: PCF11 cleavage and polyadenylation factor subunit
Synonyms: 5730417B17Rik, 2500001H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74737
Homologene: 32282
Pdia3
Name: protein disulfide isomerase associated 3
Synonyms: ERp61, ERp60, ERp57, PDI-Q2, Plca, Erp, Grp58, PDI
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14827
HGNC: HGNC:4606
Homologene: 68454
Nfib
Name: nuclear factor I/B
Synonyms: 6720429L07Rik, E030026I10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18028
HGNC: HGNC:7785
Homologene: 4087
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 63,065,735 bp
  • T to C, chromosome 1 at 87,044,030 bp
  • C to T, chromosome 1 at 87,127,749 bp
  • A to G, chromosome 1 at 116,822,365 bp
  • T to C, chromosome 1 at 132,507,617 bp
  • A to G, chromosome 1 at 139,813,526 bp
  • T to A, chromosome 1 at 150,748,993 bp
  • A to G, chromosome 2 at 13,342,498 bp
  • A to C, chromosome 2 at 24,700,022 bp
  • A to G, chromosome 2 at 27,197,690 bp
  • C to A, chromosome 2 at 37,409,605 bp
  • T to C, chromosome 2 at 76,692,766 bp
  • T to G, chromosome 2 at 121,429,521 bp
  • C to T, chromosome 2 at 150,239,519 bp
  • T to A, chromosome 2 at 152,989,603 bp
  • G to A, chromosome 3 at 94,377,608 bp
  • T to A, chromosome 3 at 103,156,107 bp
  • A to G, chromosome 4 at 58,070,262 bp
  • A to C, chromosome 4 at 82,350,440 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • A to G, chromosome 4 at 123,214,105 bp
  • C to T, chromosome 4 at 133,529,918 bp
  • A to G, chromosome 4 at 152,032,238 bp
  • A to G, chromosome 5 at 32,349,663 bp
  • A to G, chromosome 5 at 113,762,835 bp
  • A to G, chromosome 5 at 122,489,324 bp
  • T to C, chromosome 5 at 140,710,249 bp
  • T to A, chromosome 6 at 29,497,200 bp
  • T to A, chromosome 6 at 37,965,521 bp
  • T to C, chromosome 6 at 67,017,301 bp
  • C to T, chromosome 6 at 126,533,843 bp
  • C to T, chromosome 6 at 128,410,583 bp
  • T to C, chromosome 6 at 148,271,487 bp
  • A to T, chromosome 7 at 13,401,335 bp
  • A to C, chromosome 7 at 27,532,474 bp
  • A to T, chromosome 7 at 27,911,519 bp
  • A to T, chromosome 7 at 43,969,247 bp
  • A to G, chromosome 7 at 82,284,142 bp
  • A to T, chromosome 7 at 92,664,013 bp
  • A to G, chromosome 7 at 101,906,036 bp
  • G to A, chromosome 7 at 108,940,731 bp
  • G to T, chromosome 7 at 125,632,311 bp
  • T to A, chromosome 7 at 128,007,649 bp
  • A to C, chromosome 7 at 142,303,598 bp
  • T to C, chromosome 8 at 23,132,354 bp
  • T to C, chromosome 8 at 39,126,587 bp
  • C to A, chromosome 8 at 70,578,909 bp
  • C to A, chromosome 8 at 114,236,778 bp
  • A to G, chromosome 9 at 39,550,229 bp
  • C to A, chromosome 9 at 77,432,190 bp
  • A to G, chromosome 9 at 121,915,711 bp
  • A to G, chromosome 9 at 124,439,673 bp
  • A to G, chromosome 10 at 19,609,353 bp
  • A to T, chromosome 10 at 77,742,200 bp
  • A to G, chromosome 10 at 127,332,437 bp
  • T to C, chromosome 10 at 130,477,547 bp
  • T to A, chromosome 11 at 50,952,054 bp
  • A to T, chromosome 11 at 107,043,631 bp
  • T to C, chromosome 12 at 44,902,880 bp
  • A to T, chromosome 13 at 22,805,958 bp
  • T to C, chromosome 14 at 16,416,653 bp
  • T to C, chromosome 14 at 54,465,706 bp
  • A to G, chromosome 14 at 56,648,876 bp
  • C to A, chromosome 14 at 122,371,320 bp
  • A to G, chromosome 15 at 75,981,195 bp
  • A to G, chromosome 15 at 76,106,609 bp
  • A to G, chromosome 15 at 99,521,167 bp
  • G to T, chromosome 16 at 16,914,193 bp
  • A to T, chromosome 16 at 34,922,529 bp
  • A to T, chromosome 17 at 23,953,465 bp
  • G to T, chromosome 17 at 32,146,449 bp
  • A to T, chromosome 17 at 85,064,014 bp
  • T to C, chromosome 18 at 11,926,366 bp
  • A to T, chromosome 18 at 37,145,787 bp
  • A to G, chromosome 18 at 37,321,686 bp
  • G to A, chromosome 18 at 42,314,027 bp
  • C to A, chromosome 18 at 43,297,584 bp
  • G to A, chromosome 18 at 56,485,457 bp
  • T to A, chromosome 18 at 60,576,413 bp
  • C to A, chromosome 18 at 63,124,709 bp
  • T to A, chromosome 18 at 63,724,139 bp
  • C to G, chromosome 18 at 74,695,427 bp
  • A to G, chromosome 19 at 8,336,717 bp
  • A to G, chromosome 19 at 10,218,646 bp
  • A to G, chromosome 19 at 12,120,137 bp
  • T to C, chromosome 19 at 37,577,118 bp
  • C to A, chromosome 19 at 41,321,526 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7162 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045261-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.