Strain Name:
C57BL/6J-MtgxR7176Btlr/Mmmh
Stock Number:
045267-MU
Citation ID:
RRID:MMRRC_045267-MU
Other Names:
R7176 (G1)
Major Collection:

Strain Information

Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Cd86
Name: CD86 antigen
Synonyms: MB7-2, Ly58, Cd28l2, B70, B7.2, B7-2, Ly-58
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12524
HGNC: HGNC:1705
Homologene: 10443
Nrg1
Name: neuregulin 1
Synonyms: GGFII, HGL, Hgl, SMDF, GGF, HRG, D230005F13Rik, ARIA, HRGalpha, heregulin, 6030402G23Rik, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Slc27a4
Name: solute carrier family 27 (fatty acid transporter), member 4
Synonyms: FATP4, fatty acid transport protein 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26569
Homologene: 68437
Slamf6
Name: SLAM family member 6
Synonyms: KAL1b, SF2000, NTB-A, Ly108, KAL1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30925
Homologene: 49945
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 34kDa, 5033417D07Rik, D5Ertd679e, BTF2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Prepl
Name: prolyl endopeptidase-like
Synonyms: 2810457N15Rik, 9530014L06Rik, D030028O16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213760
VEGA: 17
Homologene: 15481
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: 1500002J22Rik, repro8, G1-419-52, eIF4GII, 4930523M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Wdr59
Name: WD repeat domain 59
Synonyms: 5430401O09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319481
Homologene: 38685
Ppp6r3
Name: protein phosphatase 6, regulatory subunit 3
Synonyms: Pptcs3, Pp6r3, 4930528G08Rik, Saps3, D19Bwg1430e, D19Ertd703e, 9130026N02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52036
VEGA: 19
HGNC: HGNC:1173
Homologene: 115911
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243272
Homologene: 10055
Rrp15
Name: ribosomal RNA processing 15 homolog
Synonyms: 5430437H21Rik, 2810430M08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67223
Homologene: 32293
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84505
Homologene: 32157
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228790
Homologene: 9098
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Ccnf
Name: cyclin F
Synonyms: Fbxo1, CycF
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12449
VEGA: 17
HGNC: HGNC:1591
Homologene: 1335
Adnp
Name: activity-dependent neuroprotective protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11538
Homologene: 7617
Eif3d
Name: eukaryotic translation initiation factor 3, subunit D
Synonyms: mouse translation initiation factor eIF3 p66, eIF3p66, 66/67kDa, Eif3s7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 55944
VEGA: 15
HGNC: HGNC:3278
Homologene: 2782
Aqp3
Name: aquaporin 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11828
HGNC: HGNC:636
Homologene: 21025
Runx2
Name: runt related transcription factor 2
Synonyms: AML3, PEBP2aA, Pebpa2a, Osf2, Cbfa1, PEBP2 alpha A, polyomavirus enhancer binding factor 2 (PEBP2), SL3-3 enhancer factor 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Plod1
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Synonyms: lysyl hydroxylase 1, 2410042F05Rik, LH1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18822
HGNC: HGNC:9081
Homologene: 256
Rbl1
Name: RB transcriptional corepressor like 1
Synonyms: retinoblastoma-like 1 (p107), p107
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19650
HGNC: HGNC:9893
Homologene: 2172
Fmnl2
Name: formin-like 2
Synonyms: 5430425K04Rik, man
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Lins1
Name: lines homolog 1
Synonyms: 2700083B01Rik, Wins2, Lins
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72635
Homologene: 10034
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104570
Homologene: 68886
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213773
Homologene: 4711
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237782
Homologene: 16989
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216766
Homologene: 9155
Spats2l
Name: spermatogenesis associated, serine-rich 2-like
Synonyms: 2810022L02Rik, A230104H11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67198
Homologene: 56711
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Scn6a, Nax, NaG, Nav2, Nav2.3, 1110034K09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Il1rl1
Name: interleukin 1 receptor-like 1
Synonyms: St2-rs1, T1/ST2, T1 gene, ST2, Fit-1, DER4, ST2L, St2, T1, Ly84
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17082
HGNC: HGNC:5998
Homologene: 2862
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: SM2, SM1, smMHC
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Obp2b
Name: odorant binding protein 2B
Synonyms: OTTMUSG00000012631, Lcn14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 383678
Homologene: 135821
Ccdc168
Name: coiled-coil domain containing 168
Synonyms: Gm8251
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Arvcf
Name: armadillo repeat gene deleted in velocardiofacial syndrome
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11877
HGNC: HGNC:728
Homologene: 31046
Cdkl4
Name: cyclin dependent kinase like 4
Synonyms: LOC381113
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381113
VEGA: 17
Homologene: 28725
Capn3
Name: calpain 3
Synonyms: p94, Capa-3, Lp82, Capa3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12335
HGNC: HGNC:1480
Homologene: 52
Mdm1
Name: MDM1 nuclear protein
Synonyms: Mdm-1, transformed mouse 3T3 cell double minute 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17245
VEGA: 10
Homologene: 9692
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232367
Shpk
Name: sedoheptulokinase
Synonyms: 4930431K22Rik, Carkl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74637
HGNC: HGNC:1492
Homologene: 8319
Abtb2
Name: ankyrin repeat and BTB domain containing 2
Synonyms: BPOZ-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99382
Homologene: 15904
Catip
Name: ciliogenesis associated TTC17 interacting protein
Synonyms: LOC241112, Gm216
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241112
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Foxn1
Name: forkhead box N1
Synonyms: Hfh11, whn, D11Bhm185e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15218
Homologene: 2664
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243937
Homologene: 8813
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
Adam21
Name: a disintegrin and metallopeptidase domain 21
Synonyms: ADAM31
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56622
HGNC: HGNC:200
Homologene: 68365
Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
Synonyms: 5730432L01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66634
Homologene: 12001
Abcc10
Name: ATP-binding cassette, sub-family C member 10
Synonyms: Mrp7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Zfp28
Name: zinc finger protein 28
Synonyms: mkr-5, Zfp-28, 2810438M17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22690
Homologene: 69047
Mrgprb5
Name: MAS-related GPR, member B5
Synonyms: MrgB5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404239
Homologene: 115575
Ocln
Name: occludin
Synonyms: Ocl
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18260
HGNC: HGNC:8104
Homologene: 1905
Kbtbd7
Name: kelch repeat and BTB (POZ) domain containing 7
Synonyms: LOC211255, 1110008P08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211255
VEGA: 14
Homologene: 41849
Kyat3
Name: kynurenine aminotransferase 3
Synonyms: Kat3, Ccbl2, KATIII
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229905
Homologene: 2994
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Art4
Name: ADP-ribosyltransferase 4
Synonyms: DO, DOK1, 4432404K01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109978
HGNC: HGNC:726
Homologene: 10883
Slc35g1
Name: solute carrier family 35, member G1
Synonyms: Tmem20, D330039I19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240660
VEGA: 19
Homologene: 44720
Speer4c1
Name: spermatogenesis associated glutamate (E)-rich protein 4C1
Synonyms: SPEER-4C, Speer4c, 4933431D05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100502967
Homologene: 69402
Cisd3
Name: CDGSH iron sulfur domain 3
Synonyms: Mel13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217149
Homologene: 35399
Or10ag55-ps1
Name: olfactory receptor family 10 subfamily AG member 55, pseudogene 1
Synonyms: Olfr1117-ps1, MOR264-27_p, GA_x6K02T2Q125-48769330-48770299, MOR264-10P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258110
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,446,606 bp
  • A to T, chromosome 1 at 44,060,346 bp
  • C to A, chromosome 1 at 46,430,809 bp
  • T to C, chromosome 1 at 57,937,918 bp
  • A to G, chromosome 1 at 74,362,782 bp
  • A to T, chromosome 1 at 87,480,695 bp
  • A to C, chromosome 1 at 171,934,291 bp
  • G to A, chromosome 1 at 186,721,533 bp
  • A to G, chromosome 1 at 188,537,728 bp
  • G to T, chromosome 2 at 25,737,748 bp
  • A to G, chromosome 2 at 29,811,226 bp
  • A to G, chromosome 2 at 53,114,150 bp
  • G to A, chromosome 2 at 66,676,288 bp
  • C to T, chromosome 2 at 87,285,034 bp
  • A to G, chromosome 2 at 103,709,375 bp
  • A to T, chromosome 2 at 120,504,492 bp
  • G to T, chromosome 2 at 132,820,072 bp
  • T to A, chromosome 2 at 153,401,988 bp
  • G to A, chromosome 2 at 157,188,325 bp
  • T to C, chromosome 2 at 168,182,658 bp
  • A to G, chromosome 3 at 95,337,147 bp
  • A to T, chromosome 3 at 142,737,839 bp
  • T to A, chromosome 4 at 41,095,202 bp
  • T to A, chromosome 4 at 138,171,186 bp
  • A to T, chromosome 4 at 147,913,287 bp
  • T to C, chromosome 5 at 15,711,538 bp
  • A to T, chromosome 5 at 90,268,735 bp
  • T to A, chromosome 5 at 108,168,106 bp
  • A to G, chromosome 5 at 124,392,881 bp
  • A to G, chromosome 5 at 124,590,370 bp
  • T to A, chromosome 6 at 124,192,036 bp
  • T to G, chromosome 6 at 136,857,168 bp
  • T to A, chromosome 7 at 6,383,457 bp
  • T to G, chromosome 7 at 37,480,851 bp
  • C to A, chromosome 7 at 48,168,311 bp
  • T to C, chromosome 7 at 66,713,805 bp
  • T to C, chromosome 7 at 116,388,096 bp
  • G to A, chromosome 8 at 31,968,036 bp
  • T to G, chromosome 8 at 111,492,756 bp
  • C to T, chromosome 9 at 108,845,762 bp
  • T to C, chromosome 10 at 107,778,911 bp
  • C to A, chromosome 10 at 118,142,865 bp
  • A to G, chromosome 11 at 29,198,904 bp
  • C to T, chromosome 11 at 58,166,002 bp
  • A to T, chromosome 11 at 60,778,946 bp
  • A to G, chromosome 11 at 73,222,988 bp
  • T to C, chromosome 11 at 78,360,867 bp
  • A to T, chromosome 11 at 97,686,133 bp
  • C to T, chromosome 12 at 81,560,248 bp
  • A to G, chromosome 13 at 70,624,406 bp
  • A to G, chromosome 13 at 89,688,936 bp
  • C to A, chromosome 13 at 100,515,082 bp
  • A to C, chromosome 13 at 100,515,083 bp
  • A to T, chromosome 14 at 79,427,754 bp
  • A to T, chromosome 15 at 77,963,234 bp
  • A to G, chromosome 15 at 100,169,318 bp
  • T to A, chromosome 16 at 14,215,826 bp
  • T to C, chromosome 16 at 18,399,727 bp
  • CA to CAA, chromosome 16 at 36,606,555 bp
  • A to G, chromosome 17 at 24,249,402 bp
  • G to A, chromosome 17 at 24,700,758 bp
  • A to T, chromosome 17 at 33,913,318 bp
  • G to A, chromosome 17 at 44,814,192 bp
  • G to T, chromosome 17 at 46,324,277 bp
  • A to T, chromosome 17 at 80,543,792 bp
  • T to A, chromosome 17 at 85,069,026 bp
  • G to T, chromosome 19 at 3,471,989 bp
  • A to G, chromosome 19 at 33,745,807 bp
  • T to A, chromosome 19 at 38,403,323 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7176 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045267-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.