Strain Name:
C57BL/6J-MtgxR7190Btlr/Mmmh
Stock Number:
045273-MU
Citation ID:
RRID:MMRRC_045273-MU
Other Names:
R7190 (G1)
Major Collection:

Strain Information

Gba1
Name: glucosylceramidase beta 1
Synonyms: glucocerebrosidase, GC, GCase, GBA1, betaGC, Gba
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14466
HGNC: HGNC:4177
Homologene: 68040
Thy1
Name: thymus cell antigen 1, theta
Synonyms: CD90, Thy-1, Thy 1.2, Thy1.1, Thy-1.2, Thy1.2, T25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21838
Homologene: 4580
Gpr6
Name: G protein-coupled receptor 6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 140741
VEGA: 10
HGNC: HGNC:4515
Homologene: 38026
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: C430014D17Rik, p66beta
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229542
Homologene: 32484
Rere
Name: arginine glutamic acid dipeptide (RE) repeats
Synonyms: 1110033A15Rik, atrophin-2, Atr2, eyem03Jus, eyes3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68703
HGNC: HGNC:9965
Homologene: 8101
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Capza2
Name: capping actin protein of muscle Z-line subunit alpha 2
Synonyms: Cappa2, 1110053K06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12343
HGNC: HGNC:1490
Homologene: 55956
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 2310058O09Rik, 1810059M14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100072
Homologene: 18942
Zfp626
Name: zinc finger protein 626
Synonyms: 4933426I21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71163
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Golga3
Name: golgin A3
Synonyms: Mea-2, Mea2, 5430416E01Rik, G1-499-14, repro27
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Add3
Name: adducin 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 27360
VEGA: 19
HGNC: HGNC:245
Homologene: 40893
Tmem183a
Name: transmembrane protein 183A
Synonyms: 1300007B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57439
Homologene: 10757
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Actmap
Name: actin maturation protease
Synonyms: BC024978
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 414069
Homologene: 45689
Wdr19
Name: WD repeat domain 19
Synonyms: C330027H04Rik, D330023L08Rik, Ift144, DYF2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213081
Homologene: 11842
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Nlrc4
Name: NLR family, CARD domain containing 4
Synonyms: 9530011P19Rik, Card12, Ipaf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268973
VEGA: 17
Homologene: 10924
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Il20ra
Name: interleukin 20 receptor, alpha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237313
VEGA: 10
HGNC: HGNC:6003
Homologene: 8685
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140476
Homologene: 15401
Ifi207
Name: interferon activated gene 207
Synonyms: AI607873, Pyhin-A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226691
HGNC: HGNC:5395
Homologene: 115929
Ccdc168
Name: coiled-coil domain containing 168
Synonyms: Gm8251
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
Synonyms: 2310042D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74183
Homologene: 135954
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Rpain
Name: RPA interacting protein
Synonyms: 2400006N03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69723
Homologene: 13006
Ppp2r3a
Name: protein phosphatase 2, regulatory subunit B'', alpha
Synonyms: 3222402P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235542
HGNC: HGNC:9307
Homologene: 20595
Gbp2
Name: guanylate binding protein 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14469
Homologene: 10289
Vmn1r184
Name: vomeronasal 1 receptor, 184
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312477
Homologene: 74353
Lvrn
Name: laeverin
Synonyms: 4833403I15Rik, Aqpep
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74574
VEGA: 18
Homologene: 51352
Ccdc186
Name: coiled-coil domain containing 186
Synonyms: Otg1, 1810028B20Rik, A630007B06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 213993
Homologene: 9963
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Plscr4
Name: phospholipid scramblase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235527
Homologene: 23217
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: 9930032O22Rik, Desc4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320454
Homologene: 82239
Or6c5c
Name: olfactory receptor family 6 subfamily C member 5C
Synonyms: GA_x6K02T2PULF-11141498-11142436, MOR111-10, Olfr787
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258069
Homologene: 105326
Foxj1
Name: forkhead box J1
Synonyms: Hfh4, FKHL-13, HFH-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15223
HGNC: HGNC:3816
Homologene: 1117
Zer1
Name: zyg-11 related, cell cycle regulator
Synonyms: C230075L19Rik, Zyg11bl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227693
Homologene: 4621
Or1e19
Name: olfactory receptor family 1 subfamily E member 19
Synonyms: GA_x6K02T2P1NL-3586282-3585338, MOR135-2, Olfr378
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259026
Homologene: 74110
Plpbp
Name: pyridoxal phosphate binding protein
Synonyms: 2200002F22Rik, Prosc
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114863
HGNC: HGNC:9457
Homologene: 5211
Gpr150
Name: G protein-coupled receptor 150
Synonyms: PGR11, C030001A19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238725
Homologene: 18457
Tsen34
Name: tRNA splicing endonuclease subunit 34
Synonyms: 0610027F08Rik, Leng5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66078
Homologene: 44182
Tcl1b2
Name: T cell leukemia/lymphoma 1B, 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27381
Homologene: 83274
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73246
Homologene: 37125
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 44,061,615 bp
  • A to G, chromosome 1 at 100,431,849 bp
  • A to T, chromosome 1 at 134,354,758 bp
  • G to A, chromosome 1 at 173,730,252 bp
  • T to A, chromosome 2 at 19,293,136 bp
  • T to C, chromosome 2 at 30,103,432 bp
  • T to C, chromosome 2 at 76,886,799 bp
  • T to G, chromosome 2 at 121,369,026 bp
  • T to A, chromosome 3 at 89,204,362 bp
  • T to A, chromosome 3 at 90,350,415 bp
  • T to C, chromosome 3 at 142,633,447 bp
  • T to A, chromosome 4 at 118,389,006 bp
  • A to G, chromosome 4 at 150,610,953 bp
  • T to G, chromosome 4 at 151,148,523 bp
  • A to G, chromosome 4 at 156,219,815 bp
  • C to A, chromosome 5 at 14,679,729 bp
  • A to C, chromosome 5 at 22,047,947 bp
  • A to C, chromosome 5 at 41,819,938 bp
  • A to G, chromosome 5 at 65,240,862 bp
  • T to C, chromosome 5 at 86,496,632 bp
  • T to C, chromosome 5 at 90,606,807 bp
  • T to G, chromosome 5 at 94,218,237 bp
  • T to A, chromosome 5 at 110,209,855 bp
  • T to A, chromosome 6 at 17,654,121 bp
  • T to C, chromosome 6 at 135,732,948 bp
  • T to C, chromosome 7 at 3,694,807 bp
  • T to C, chromosome 7 at 26,267,680 bp
  • G to A, chromosome 7 at 27,201,123 bp
  • A to T, chromosome 7 at 27,818,343 bp
  • G to T, chromosome 8 at 27,051,297 bp
  • T to A, chromosome 9 at 44,046,925 bp
  • A to T, chromosome 9 at 92,488,641 bp
  • A to T, chromosome 9 at 101,212,527 bp
  • A to T, chromosome 10 at 19,742,941 bp
  • T to C, chromosome 10 at 41,070,960 bp
  • T to C, chromosome 10 at 117,762,135 bp
  • T to C, chromosome 10 at 129,462,757 bp
  • G to T, chromosome 11 at 69,549,097 bp
  • A to G, chromosome 11 at 70,971,909 bp
  • A to T, chromosome 11 at 73,425,164 bp
  • A to G, chromosome 11 at 116,332,375 bp
  • T to A, chromosome 12 at 76,066,587 bp
  • G to T, chromosome 12 at 105,147,234 bp
  • C to T, chromosome 13 at 76,055,873 bp
  • G to T, chromosome 17 at 74,445,203 bp
  • A to G, chromosome 18 at 5,092,937 bp
  • T to C, chromosome 18 at 25,090,755 bp
  • A to G, chromosome 18 at 46,900,503 bp
  • C to T, chromosome 19 at 53,216,899 bp
  • T to A, chromosome 19 at 56,792,000 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7190 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045273-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.