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Strain Name:
C57BL/6J-MtgxR7190Btlr/Mmmh
Stock Number:
045273-MU
Citation ID:
RRID:MMRRC_045273-MU
Other Names:
R7190 (G1)
Major Collection:

Strain Information

Gba1
Name: glucosylceramidase beta 1
Synonyms: glucocerebrosidase, GC, GCase, GBA1, betaGC, Gba
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14466
HGNC: HGNC:4177
Homologene: 68040
Thy1
Name: thymus cell antigen 1, theta
Synonyms: CD90, Thy-1, Thy 1.2, Thy1.1, Thy-1.2, Thy1.2, T25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21838
Homologene: 4580
Gpr6
Name: G protein-coupled receptor 6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 140741
VEGA: 10
HGNC: HGNC:4515
Homologene: 38026
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: C430014D17Rik, p66beta
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229542
Homologene: 32484
Rere
Name: arginine glutamic acid dipeptide (RE) repeats
Synonyms: 1110033A15Rik, atrophin-2, Atr2, eyem03Jus, eyes3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68703
HGNC: HGNC:9965
Homologene: 8101
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Capza2
Name: capping actin protein of muscle Z-line subunit alpha 2
Synonyms: Cappa2, 1110053K06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12343
HGNC: HGNC:1490
Homologene: 55956
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 44,061,615 bp
  • A to G, chromosome 1 at 100,431,849 bp
  • A to T, chromosome 1 at 134,354,758 bp
  • G to A, chromosome 1 at 173,730,252 bp
  • T to A, chromosome 2 at 19,293,136 bp
  • T to C, chromosome 2 at 30,103,432 bp
  • T to C, chromosome 2 at 76,886,799 bp
  • T to G, chromosome 2 at 121,369,026 bp
  • T to A, chromosome 3 at 89,204,362 bp
  • T to A, chromosome 3 at 90,350,415 bp
  • T to C, chromosome 3 at 142,633,447 bp
  • T to A, chromosome 4 at 118,389,006 bp
  • A to G, chromosome 4 at 150,610,953 bp
  • T to G, chromosome 4 at 151,148,523 bp
  • A to G, chromosome 4 at 156,219,815 bp
  • C to A, chromosome 5 at 14,679,729 bp
  • A to C, chromosome 5 at 22,047,947 bp
  • A to C, chromosome 5 at 41,819,938 bp
  • A to G, chromosome 5 at 65,240,862 bp
  • T to C, chromosome 5 at 86,496,632 bp
  • T to C, chromosome 5 at 90,606,807 bp
  • T to G, chromosome 5 at 94,218,237 bp
  • T to A, chromosome 5 at 110,209,855 bp
  • T to A, chromosome 6 at 17,654,121 bp
  • T to C, chromosome 6 at 135,732,948 bp
  • T to C, chromosome 7 at 3,694,807 bp
  • T to C, chromosome 7 at 26,267,680 bp
  • G to A, chromosome 7 at 27,201,123 bp
  • A to T, chromosome 7 at 27,818,343 bp
  • G to T, chromosome 8 at 27,051,297 bp
  • T to A, chromosome 9 at 44,046,925 bp
  • A to T, chromosome 9 at 92,488,641 bp
  • A to T, chromosome 9 at 101,212,527 bp
  • A to T, chromosome 10 at 19,742,941 bp
  • T to C, chromosome 10 at 41,070,960 bp
  • T to C, chromosome 10 at 117,762,135 bp
  • T to C, chromosome 10 at 129,462,757 bp
  • G to T, chromosome 11 at 69,549,097 bp
  • A to G, chromosome 11 at 70,971,909 bp
  • A to T, chromosome 11 at 73,425,164 bp
  • A to G, chromosome 11 at 116,332,375 bp
  • T to A, chromosome 12 at 76,066,587 bp
  • G to T, chromosome 12 at 105,147,234 bp
  • C to T, chromosome 13 at 76,055,873 bp
  • G to T, chromosome 17 at 74,445,203 bp
  • A to G, chromosome 18 at 5,092,937 bp
  • T to C, chromosome 18 at 25,090,755 bp
  • A to G, chromosome 18 at 46,900,503 bp
  • C to T, chromosome 19 at 53,216,899 bp
  • T to A, chromosome 19 at 56,792,000 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7190 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045273-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.