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Strain Name:
C57BL/6J-MtgxR7230Btlr/Mmmh
Stock Number:
045302-MU
Citation ID:
RRID:MMRRC_045302-MU
Other Names:
R7230 (G1)
Major Collection:

Strain Information

Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Cxcr4
Name: C-X-C motif chemokine receptor 4
Synonyms: PB-CKR, fusin, CD184, Cmkar4, Sdf1r, b2b220Clo
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12767
HGNC: HGNC:2561
Homologene: 20739
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Cct3
Name: chaperonin containing TCP1 subunit 3
Synonyms: TriC-P5, Cctg, Tcp1-rs3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12462
HGNC: HGNC:1616
Homologene: 4373
Arb2a
Name: ARB2 cotranscriptional regulator A
Synonyms: pEN87, 53-E6, 2610318O14Rik, 9430037D06Rik, 1110033M05Rik, Fam172a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68675
VEGA: 13
Homologene: 12933
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,502,147 bp
  • T to C, chromosome 1 at 40,600,771 bp
  • T to A, chromosome 1 at 85,848,159 bp
  • T to G, chromosome 1 at 128,589,790 bp
  • T to C, chromosome 1 at 135,406,758 bp
  • T to C, chromosome 1 at 164,184,953 bp
  • C to A, chromosome 2 at 20,797,988 bp
  • C to T, chromosome 2 at 26,908,211 bp
  • A to T, chromosome 2 at 76,738,700 bp
  • A to T, chromosome 2 at 111,420,916 bp
  • T to A, chromosome 2 at 111,912,561 bp
  • G to T, chromosome 2 at 118,791,805 bp
  • T to A, chromosome 2 at 121,300,818 bp
  • A to T, chromosome 2 at 131,053,563 bp
  • T to C, chromosome 3 at 14,505,381 bp
  • A to G, chromosome 3 at 37,065,166 bp
  • C to T, chromosome 3 at 88,313,260 bp
  • T to G, chromosome 3 at 106,572,978 bp
  • T to C, chromosome 3 at 144,434,546 bp
  • C to A, chromosome 4 at 56,972,372 bp
  • T to A, chromosome 4 at 116,588,610 bp
  • T to C, chromosome 4 at 119,339,782 bp
  • A to T, chromosome 5 at 108,671,745 bp
  • T to C, chromosome 6 at 29,206,063 bp
  • A to G, chromosome 6 at 34,487,567 bp
  • A to G, chromosome 7 at 25,023,070 bp
  • A to C, chromosome 7 at 46,117,388 bp
  • C to T, chromosome 7 at 81,093,294 bp
  • A to T, chromosome 7 at 106,689,524 bp
  • C to A, chromosome 7 at 106,818,179 bp
  • T to C, chromosome 7 at 141,649,214 bp
  • C to A, chromosome 8 at 25,954,832 bp
  • T to A, chromosome 9 at 49,509,823 bp
  • T to G, chromosome 9 at 119,124,538 bp
  • A to G, chromosome 10 at 41,678,813 bp
  • A to T, chromosome 11 at 46,810,864 bp
  • A to G, chromosome 12 at 29,783,874 bp
  • T to A, chromosome 12 at 75,933,900 bp
  • T to C, chromosome 12 at 87,464,554 bp
  • A to C, chromosome 12 at 113,545,582 bp
  • T to A, chromosome 13 at 27,433,038 bp
  • T to A, chromosome 13 at 65,194,901 bp
  • A to T, chromosome 13 at 67,491,963 bp
  • G to A, chromosome 13 at 77,759,472 bp
  • C to T, chromosome 16 at 4,649,622 bp
  • A to G, chromosome 16 at 97,578,597 bp
  • C to T, chromosome 17 at 6,231,780 bp
  • C to A, chromosome 17 at 15,706,937 bp
  • A to T, chromosome 17 at 25,123,103 bp
  • A to G, chromosome 17 at 35,909,439 bp
  • T to G, chromosome 17 at 56,369,155 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7230 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045302-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.