Strain Name:
C57BL/6J-MtgxR7230Btlr/Mmmh
Stock Number:
045302-MU
Citation ID:
RRID:MMRRC_045302-MU
Other Names:
R7230 (G1)
Major Collection:

Strain Information

Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Cxcr4
Name: C-X-C motif chemokine receptor 4
Synonyms: fusin, CD184, Cmkar4, PB-CKR, Sdf1r, b2b220Clo
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12767
HGNC: HGNC:2561
Homologene: 20739
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Etl4
Name: enhancer trap locus 4
Synonyms: 6620402G01Rik, Sickle tail, Skt, Etl-4, 9430077C05Rik, E330027G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Cct3
Name: chaperonin containing TCP1 subunit 3
Synonyms: TriC-P5, Cctg, Tcp1-rs3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12462
HGNC: HGNC:1616
Homologene: 4373
Arb2a
Name: ARB2 cotranscriptional regulator A
Synonyms: 2610318O14Rik, 1110033M05Rik, pEN87, 53-E6, Fam172a, 9430037D06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68675
VEGA: 13
Homologene: 12933
Snw1
Name: SNW domain containing 1
Synonyms: 2310008B08Rik, SKIP, NCoA-62, Skiip, SNW1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66354
VEGA: 12
Homologene: 56557
Bpgm
Name: 2,3-bisphosphoglycerate mutase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12183
HGNC: HGNC:1093
Homologene: 55599
Gpbp1l1
Name: GC-rich promoter binding protein 1-like 1
Synonyms: 5330440M15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77110
Homologene: 84840
Ipo9
Name: importin 9
Synonyms: 0710008K06Rik, Imp9
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226432
Homologene: 5874
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: NCAM-180, NCAM-1, NCAM, NCAM-120, E-NCAM, CD56, NCAM-140
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Adam33
Name: a disintegrin and metallopeptidase domain 33
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110751
Homologene: 11881
Dram2
Name: DNA-damage regulated autophagy modulator 2
Synonyms: Tmem77, 2610318G18Rik, 2010305N14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67171
Homologene: 23565
Tmprss2
Name: transmembrane protease, serine 2
Synonyms: epitheliasin, D16Ertd61e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50528
VEGA: 16
Homologene: 4136
Vasn
Name: vasorin
Synonyms: 2610528G05Rik, ATIA, Slitl2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 246154
Homologene: 36929
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: D730009J23Rik, NHE4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110895
Homologene: 72232
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: D8Ertd354e, 9430010M12Rik, Tmem76
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52120
Homologene: 15586
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: syne-2, 6820443O06Rik, D12Ertd777e, nesprin-2, Cpfl8, Nesp2g, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Prl8a6
Name: prolactin family 8, subfamily a, member 6
Synonyms: PLP-Ca, Prlpc1, PLP-calpha, Prlpc
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19112
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Hs2st1
Name: heparan sulfate 2-O-sulfotransferase 1
Synonyms: Hs2st
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23908
HGNC: HGNC:5193
Homologene: 8025
Adad1
Name: adenosine deaminase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21744
Homologene: 7569
Myt1l
Name: myelin transcription factor 1-like
Synonyms: 2900046C06Rik, C630034G21Rik, Png-1, 2900093J19Rik, Nztf1, Pmng1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Tulp4
Name: TUB like protein 4
Synonyms: 1110057P05Rik, 2210038L17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68842
Homologene: 32467
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: GluRgamma2, KA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Impdh1
Name: inosine monophosphate dehydrogenase 1
Synonyms: B930086D20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23917
HGNC: HGNC:6052
Homologene: 68096
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Alpk3
Name: alpha-kinase 3
Synonyms: Midori
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 116904
Homologene: 10813
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1, Mtap1a, 6330416M19Rik, Mtap-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Disp2
Name: dispatched RND transporter family member 2
Synonyms: B230210L08Rik, DispB
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Prss39
Name: serine protease 39
Synonyms: Tesp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21755
Homologene: 84781
Ccdc30
Name: coiled-coil domain containing 30
Synonyms: 1700001O02Rik, 4930445I03Rik, 1700041C02Rik, 1700111D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73332
Homologene: 137391
Or2ag1b
Name: olfactory receptor family 2 subfamily AG member 1B
Synonyms: Olfr694, GA_x6K02T2PBJ9-9067220-9066273, MOR283-9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258444
Homologene: 79345
Or2ag2b
Name: olfactory receptor family 2 subfamily AG member 2B
Synonyms: MOR283-1, GA_x6K02T2PBJ9-9195805-9196755, 4932441H21Rik, Olfr701, 4933433E02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66786
Homologene: 12558
Cab39
Name: calcium binding protein 39
Synonyms: MO25alpha, 39kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12283
Homologene: 69212
Timd4
Name: T cell immunoglobulin and mucin domain containing 4
Synonyms: Tim4, B430010N18Rik, TIM-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276891
Homologene: 51381
Nlrp4f
Name: NLR family, pyrin domain containing 4F
Synonyms: Nalp-kappa, C330026N02Rik, Nalp4f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97895
VEGA: 13
Homologene: 87252
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: Gm6976, Gm29096, 5033413D22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Zfp58
Name: zinc finger protein 58
Synonyms: A530094I17Rik, Mfg-1, Mfg1, Zfp817
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238693
Or4f14
Name: olfactory receptor family 4 subfamily F member 14
Synonyms: Olfr1306, GA_x6K02T2Q125-72954873-72953935, MOR245-15
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258023
Homologene: 128383
Ptx4
Name: pentraxin 4
Synonyms: 1110018H23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68509
VEGA: 17
Homologene: 19179
Or4k40
Name: olfactory receptor family 4 subfamily K member 40
Synonyms: Olfr1286, MOR248-21, GA_x6K02T2Q125-72472405-72471488
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277562
Homologene: 73992
Atat1
Name: alpha tubulin acetyltransferase 1
Synonyms: 2610110G12Rik, 2610008K08Rik, MEC-17, 3110080J08Rik, 0610011P08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73242
Homologene: 15129
Med22
Name: mediator complex subunit 22
Synonyms: Surf5, Surf-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20933
Homologene: 4913
Slc26a1
Name: solute carrier family 26 (sulfate transporter), member 1
Synonyms: Sat1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231583
Homologene: 32539
Slc7a12
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
Synonyms: asc-type amino acid transporter 2, Asc-2, XAT1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140918
Homologene: 76812
Frrs1l
Name: ferric-chelate reductase 1 like
Synonyms: 6430704M03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230235
HGNC: HGNC:1362
Homologene: 87703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,502,147 bp
  • T to C, chromosome 1 at 40,600,771 bp
  • T to A, chromosome 1 at 85,848,159 bp
  • T to G, chromosome 1 at 128,589,790 bp
  • T to C, chromosome 1 at 135,406,758 bp
  • T to C, chromosome 1 at 164,184,953 bp
  • C to A, chromosome 2 at 20,797,988 bp
  • C to T, chromosome 2 at 26,908,211 bp
  • A to T, chromosome 2 at 76,738,700 bp
  • A to T, chromosome 2 at 111,420,916 bp
  • T to A, chromosome 2 at 111,912,561 bp
  • G to T, chromosome 2 at 118,791,805 bp
  • T to A, chromosome 2 at 121,300,818 bp
  • A to T, chromosome 2 at 131,053,563 bp
  • T to C, chromosome 3 at 14,505,381 bp
  • A to G, chromosome 3 at 37,065,166 bp
  • C to T, chromosome 3 at 88,313,260 bp
  • T to G, chromosome 3 at 106,572,978 bp
  • T to C, chromosome 3 at 144,434,546 bp
  • C to A, chromosome 4 at 56,972,372 bp
  • T to A, chromosome 4 at 116,588,610 bp
  • T to C, chromosome 4 at 119,339,782 bp
  • A to T, chromosome 5 at 108,671,745 bp
  • T to C, chromosome 6 at 29,206,063 bp
  • A to G, chromosome 6 at 34,487,567 bp
  • A to G, chromosome 7 at 25,023,070 bp
  • A to C, chromosome 7 at 46,117,388 bp
  • C to T, chromosome 7 at 81,093,294 bp
  • A to T, chromosome 7 at 106,689,524 bp
  • C to A, chromosome 7 at 106,818,179 bp
  • T to C, chromosome 7 at 141,649,214 bp
  • C to A, chromosome 8 at 25,954,832 bp
  • T to A, chromosome 9 at 49,509,823 bp
  • T to G, chromosome 9 at 119,124,538 bp
  • A to G, chromosome 10 at 41,678,813 bp
  • A to T, chromosome 11 at 46,810,864 bp
  • A to G, chromosome 12 at 29,783,874 bp
  • T to A, chromosome 12 at 75,933,900 bp
  • T to C, chromosome 12 at 87,464,554 bp
  • A to C, chromosome 12 at 113,545,582 bp
  • T to A, chromosome 13 at 27,433,038 bp
  • T to A, chromosome 13 at 65,194,901 bp
  • A to T, chromosome 13 at 67,491,963 bp
  • G to A, chromosome 13 at 77,759,472 bp
  • C to T, chromosome 16 at 4,649,622 bp
  • A to G, chromosome 16 at 97,578,597 bp
  • C to T, chromosome 17 at 6,231,780 bp
  • C to A, chromosome 17 at 15,706,937 bp
  • A to T, chromosome 17 at 25,123,103 bp
  • A to G, chromosome 17 at 35,909,439 bp
  • T to G, chromosome 17 at 56,369,155 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7230 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045302-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.