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Strain Name:
C57BL/6J-MtgxR7291Btlr/Mmmh
Stock Number:
045322-MU
Citation ID:
RRID:MMRRC_045322-MU
Other Names:
R7291 (G1)
Major Collection:

Strain Information

Card11
Name: caspase recruitment domain family, member 11
Synonyms: CARMA1, BIMP3, 2410011D02Rik, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Psen2
Name: presenilin 2
Synonyms: ALG-3, PS-2, PS2, Ad4h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19165
HGNC: HGNC:9509
Homologene: 386
Fam110b
Name: family with sequence similarity 110, member B
Synonyms: 1700012H17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242297
Homologene: 17518
Prepl
Name: prolyl endopeptidase-like
Synonyms: 9530014L06Rik, 2810457N15Rik, D030028O16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213760
VEGA: 17
Homologene: 15481
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20981
Homologene: 9617
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,914,594 bp
  • G to T, chromosome 1 at 75,489,517 bp
  • A to G, chromosome 1 at 135,465,859 bp
  • G to T, chromosome 1 at 162,887,702 bp
  • A to G, chromosome 1 at 164,053,868 bp
  • G to A, chromosome 1 at 171,256,528 bp
  • C to T, chromosome 1 at 173,974,815 bp
  • C to T, chromosome 1 at 178,679,046 bp
  • C to T, chromosome 1 at 180,238,956 bp
  • C to T, chromosome 2 at 11,718,381 bp
  • C to T, chromosome 2 at 26,476,375 bp
  • T to A, chromosome 2 at 60,329,993 bp
  • T to C, chromosome 2 at 60,530,435 bp
  • T to C, chromosome 2 at 61,812,256 bp
  • A to G, chromosome 2 at 82,980,519 bp
  • A to T, chromosome 2 at 143,969,462 bp
  • C to T, chromosome 2 at 154,267,696 bp
  • A to T, chromosome 2 at 181,088,379 bp
  • T to C, chromosome 3 at 19,227,674 bp
  • T to C, chromosome 3 at 87,385,781 bp
  • T to C, chromosome 3 at 90,351,414 bp
  • A to G, chromosome 3 at 138,091,203 bp
  • T to C, chromosome 3 at 138,282,808 bp
  • T to A, chromosome 4 at 5,798,895 bp
  • A to G, chromosome 4 at 48,208,792 bp
  • T to A, chromosome 4 at 115,811,091 bp
  • A to G, chromosome 4 at 118,391,249 bp
  • G to A, chromosome 4 at 137,752,698 bp
  • C to A, chromosome 4 at 154,998,472 bp
  • A to T, chromosome 5 at 87,411,895 bp
  • A to G, chromosome 5 at 139,765,074 bp
  • T to C, chromosome 5 at 140,901,070 bp
  • G to A, chromosome 6 at 71,941,456 bp
  • T to A, chromosome 6 at 124,625,384 bp
  • A to G, chromosome 7 at 28,101,392 bp
  • A to C, chromosome 7 at 28,140,220 bp
  • T to C, chromosome 7 at 28,759,203 bp
  • G to A, chromosome 7 at 44,395,919 bp
  • T to A, chromosome 7 at 103,442,788 bp
  • C to A, chromosome 7 at 120,289,609 bp
  • T to G, chromosome 7 at 130,519,931 bp
  • C to T, chromosome 7 at 133,587,223 bp
  • A to G, chromosome 7 at 145,307,469 bp
  • T to G, chromosome 8 at 80,800,151 bp
  • G to A, chromosome 8 at 122,813,577 bp
  • T to G, chromosome 8 at 126,394,558 bp
  • T to A, chromosome 9 at 6,929,590 bp
  • T to C, chromosome 9 at 19,808,648 bp
  • A to T, chromosome 9 at 107,549,304 bp
  • C to T, chromosome 9 at 120,417,141 bp
  • A to T, chromosome 10 at 33,437,736 bp
  • T to C, chromosome 10 at 77,782,227 bp
  • G to A, chromosome 10 at 86,946,220 bp
  • T to C, chromosome 10 at 130,112,224 bp
  • T to C, chromosome 11 at 54,691,239 bp
  • A to T, chromosome 11 at 84,009,381 bp
  • C to T, chromosome 11 at 100,710,900 bp
  • T to C, chromosome 11 at 116,074,050 bp
  • A to G, chromosome 12 at 51,925,339 bp
  • T to A, chromosome 12 at 59,158,369 bp
  • T to C, chromosome 12 at 80,174,085 bp
  • T to C, chromosome 12 at 91,848,965 bp
  • C to T, chromosome 13 at 22,278,749 bp
  • T to C, chromosome 13 at 34,197,839 bp
  • G to A, chromosome 13 at 97,175,024 bp
  • A to T, chromosome 14 at 31,298,705 bp
  • A to T, chromosome 14 at 43,922,920 bp
  • A to T, chromosome 14 at 44,859,192 bp
  • G to A, chromosome 14 at 53,312,942 bp
  • G to A, chromosome 14 at 64,032,298 bp
  • T to C, chromosome 15 at 34,355,553 bp
  • T to C, chromosome 15 at 63,902,840 bp
  • C to T, chromosome 15 at 78,672,983 bp
  • T to A, chromosome 15 at 102,502,166 bp
  • T to C, chromosome 17 at 14,001,581 bp
  • T to C, chromosome 17 at 20,574,209 bp
  • T to A, chromosome 17 at 25,244,317 bp
  • T to A, chromosome 17 at 32,883,854 bp
  • T to A, chromosome 17 at 36,325,729 bp
  • C to T, chromosome 17 at 46,540,433 bp
  • T to C, chromosome 17 at 80,227,775 bp
  • T to C, chromosome 17 at 85,081,240 bp
  • A to T, chromosome 19 at 13,282,153 bp
  • T to C, chromosome 19 at 57,215,908 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7291 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045322-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.