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Strain Name:
C57BL/6J-MtgxR6463Btlr/Mmmh
Stock Number:
045324-MU
Citation ID:
RRID:MMRRC_045324-MU
Other Names:
R6463 (G1)
Major Collection:

Strain Information

Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk-2, Tsk2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Trhr
Name: thyrotropin releasing hormone receptor
Synonyms: TRH-R1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22045
VEGA: 15
Homologene: 20707
Trh
Name: thyrotropin releasing hormone
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22044
Homologene: 5163
Cep63
Name: centrosomal protein 63
Synonyms: CD20R, ET2, D9Mgc41, D9Mgc48e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 28135
Homologene: 11861
Chpf2
Name: chondroitin polymerizing factor 2
Synonyms: 2010209O12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100910
Homologene: 14763
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: 2310047C21Rik, D8Wsu49e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71927
Homologene: 12423
Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Synonyms: methionine synthase, MS, D830038K18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238505
VEGA: 13
HGNC: HGNC:7468
Homologene: 37280
Ucp3
Name: uncoupling protein 3 (mitochondrial, proton carrier)
Synonyms: UCP-3, Slc25a9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22229
Homologene: 2517
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, Siat4, ST3GalI, Siat4a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Elfn1
Name: leucine rich repeat and fibronectin type III, extracellular 1
Synonyms: A930017N06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243312
Homologene: 18465
Nkx6-1
Name: NK6 homeobox 1
Synonyms: NKX6A, Nkx6.1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18096
HGNC: HGNC:7839
Homologene: 4495
Epha5
Name: Eph receptor A5
Synonyms: Cek7, bsk, Els1, Rek7, Hek7, Ehk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Aifm3
Name: apoptosis-inducing factor, mitochondrion-associated 3
Synonyms: 2810401C16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72168
Homologene: 13773
Ttll7
Name: tubulin tyrosine ligase-like family, member 7
Synonyms: 1110049N09Rik, 4921517B04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70892
Homologene: 41578
Izumo2
Name: IZUMO family member 2
Synonyms: 1700023D19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75510
Dbt
Name: dihydrolipoamide branched chain transacylase E2
Synonyms: BCKAD E2, D3Wsu60e, dihydrolipoyl transacylase, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13171
HGNC: HGNC:2698
Homologene: 1444
Tmx4
Name: thioredoxin-related transmembrane protein 4
Synonyms: 4930500L08Rik, 2810417D04Rik, D2Bwg1356e, Txndc13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 52837
Homologene: 10901
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Naglu
Name: alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27419
HGNC: HGNC:7632
Homologene: 222
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Mettl2
Name: methyltransferase 2, methylcytidine
Synonyms: C130031G21Rik, PSENIP1, D11Ertd768e, 2810438F06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52686
Homologene: 10174
Slc13a3
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms: SDCT2, NaDC3, NaDC-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 114644
Homologene: 11266
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: LL5beta, LL5b, C820004H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208177
Homologene: 17100
Oas2
Name: 2'-5' oligoadenylate synthetase 2
Synonyms: 2'-5' oligoadenylate synthetase-like 11, Oasl11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246728
HGNC: HGNC:8087
Homologene: 49478
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: D530004J12Rik, Ccdc129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232016
Homologene: 52344
Kbtbd3
Name: kelch repeat and BTB (POZ) domain containing 3
Synonyms: 2200003A07Rik, Bklhd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69149
Homologene: 12300
Ddx31
Name: DEAD/H box helicase 31
Synonyms: 5830444G11Rik, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227674
Homologene: 6389
Dnm1
Name: dynamin 1
Synonyms: dynamin 1, Ftfl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13429
HGNC: HGNC:2972
Homologene: 123905
Zfp687
Name: zinc finger protein 687
Synonyms: 4931408L03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78266
Homologene: 10827
Or2ag16
Name: olfactory receptor family 2 subfamily AG member 16
Synonyms: GA_x6K02T2PBJ9-9130754-9129519, MOR283-3, Olfr698
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258595
Homologene: 133598
Or10h1
Name: olfactory receptor family 10 subfamily H member 1
Synonyms: GA_x6K02T2KN0P-2543-1596, MOR267-10, Olfr239
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100038860
Homologene: 110515
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255, V2r28
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665255
Homologene: 129605
1700009N14Rik
Name: RIKEN cDNA 1700009N14 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75471
Homologene: 128450
Rdh7
Name: retinol dehydrogenase 7
Synonyms: CRAD2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54150
Homologene: 137324
Hkdc1
Name: hexokinase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216019
Homologene: 128937
Fbp1
Name: fructose bisphosphatase 1
Synonyms: FBPase brain isoform, FBPase liver, Fbp-2, Fbp3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14121
HGNC: HGNC:3606
Homologene: 55467
Asb7
Name: ankyrin repeat and SOCS box-containing 7
Synonyms: Asb-7, D030055C23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 117589
Homologene: 34130
Ntpcr
Name: nucleoside-triphosphatase, cancer-related
Synonyms: 2310079N02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66566
Homologene: 11989
Slc6a20b
Name: solute carrier family 6 (neurotransmitter transporter), member 20B
Synonyms: XT3, Xtrp3, Sit1, Slc6a20
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22599
Homologene: 130652
Uck1
Name: uridine-cytidine kinase 1
Synonyms: URK1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22245
Homologene: 7990
Or4p8
Name: olfactory receptor family 4 subfamily P member 8
Synonyms: GA_x6K02T2Q125-50372411-50371485, MOR225-4, Olfr1208
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258774
Homologene: 74190
Csl
Name: citrate synthase like
Synonyms: 1700007H16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71832
VEGA: 10
HGNC: HGNC:2422
Homologene: 7131
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 45,342,205 bp
  • T to A, chromosome 2 at 28,847,513 bp
  • T to C, chromosome 2 at 32,258,655 bp
  • T to C, chromosome 2 at 32,309,591 bp
  • T to C, chromosome 2 at 84,736,743 bp
  • T to C, chromosome 2 at 88,897,118 bp
  • T to C, chromosome 2 at 134,620,639 bp
  • A to C, chromosome 2 at 165,445,653 bp
  • A to G, chromosome 3 at 95,010,784 bp
  • A to G, chromosome 3 at 116,539,760 bp
  • G to A, chromosome 3 at 146,931,582 bp
  • T to C, chromosome 4 at 32,773,308 bp
  • A to T, chromosome 4 at 39,450,938 bp
  • T to C, chromosome 4 at 149,192,596 bp
  • G to T, chromosome 5 at 24,589,526 bp
  • T to A, chromosome 5 at 84,106,710 bp
  • G to T, chromosome 5 at 101,659,476 bp
  • T to C, chromosome 5 at 120,734,981 bp
  • A to G, chromosome 5 at 139,972,285 bp
  • A to T, chromosome 6 at 23,323,334 bp
  • A to G, chromosome 6 at 55,968,678 bp
  • A to T, chromosome 6 at 92,242,843 bp
  • T to A, chromosome 7 at 5,486,436 bp
  • A to G, chromosome 7 at 44,709,074 bp
  • A to T, chromosome 7 at 66,660,236 bp
  • A to T, chromosome 7 at 100,480,269 bp
  • C to G, chromosome 7 at 106,752,801 bp
  • A to G, chromosome 8 at 85,736,151 bp
  • A to G, chromosome 8 at 125,736,104 bp
  • A to G, chromosome 9 at 4,316,921 bp
  • C to A, chromosome 9 at 102,596,155 bp
  • T to C, chromosome 9 at 114,625,902 bp
  • T to A, chromosome 9 at 123,604,949 bp
  • T to C, chromosome 10 at 62,393,702 bp
  • T to C, chromosome 10 at 99,759,098 bp
  • T to C, chromosome 10 at 127,885,781 bp
  • G to A, chromosome 11 at 72,308,638 bp
  • A to G, chromosome 11 at 101,077,351 bp
  • G to A, chromosome 11 at 105,132,581 bp
  • T to C, chromosome 13 at 12,216,866 bp
  • A to G, chromosome 13 at 62,865,010 bp
  • A to G, chromosome 15 at 44,197,585 bp
  • T to C, chromosome 15 at 47,676,479 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • T to C, chromosome 15 at 80,355,758 bp
  • A to G, chromosome 16 at 17,500,789 bp
  • A to C, chromosome 16 at 45,774,993 bp
  • G to A, chromosome 17 at 33,199,638 bp
  • G to A, chromosome 17 at 44,085,264 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6463 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045324-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.