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Strain Name:
C57BL/6J-MtgxR7125Btlr/Mmmh
Stock Number:
045327-MU
Citation ID:
RRID:MMRRC_045327-MU
Other Names:
R7125 (G1)
Major Collection:

Strain Information

Sulf2
Name: sulfatase 2
Synonyms: 2010004N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72043
Homologene: 10313
Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
Synonyms: 1810048F20Rik, Fthfd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107747
HGNC: HGNC:3978
Homologene: 122031
Trim59
Name: tripartite motif-containing 59
Synonyms: 2700022F13Rik, TSBF1, Mrf1, 2310035M22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66949
Homologene: 32644
Prkca
Name: protein kinase C, alpha
Synonyms: Pkca
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18750
HGNC: HGNC:9393
Homologene: 55679
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Ago3
Name: argonaute RISC catalytic subunit 3
Synonyms: argonaute 3, eIF2C3, C130014L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214150
Homologene: 49799
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66691
Homologene: 32637
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Stim1
Name: stromal interaction molecule 1
Synonyms: SIM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20866
Homologene: 20681
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Cars1
Name: cysteinyl-tRNA synthetase 1
Synonyms: CA3, Cars
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27267
HGNC: HGNC:1493
Homologene: 1328
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99100
Homologene: 37159
Firrm
Name: FIGNL1 interacting regulator of recombination and mitosis
Synonyms: BC055324, Flip
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381306
Homologene: 10058
Slc25a22
Name: solute carrier family 25 (mitochondrial carrier, glutamate), member 22
Synonyms: 1300006L01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68267
Homologene: 69383
Fyb1
Name: FYN binding protein 1
Synonyms: FYB-120/130, ADAP, B630013F22Rik, Fyb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23880
HGNC: HGNC:4036
Homologene: 22664
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: 2410066K11Rik, line 158, Thm1, aln
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73668
Homologene: 57006
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: Pept2, 8430408C16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57738
Homologene: 56912
Golgb1
Name: golgin B1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105841
Homologene: 28254
Hexd
Name: hexosaminidase D
Synonyms: Hexdc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 238023
Homologene: 68120
Sp140
Name: Sp140 nuclear body protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 434484
Homologene: 128391
Ptpre
Name: protein tyrosine phosphatase receptor type E
Synonyms: PTPe, PTPepsilon, RPTPepsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Or11h7
Name: olfactory receptor family 11 subfamily H member 7
Synonyms: GA_x6K02T2PMLR-6372116-6373060, MOR106-12, Olfr746
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258295
Homologene: 134081
Micu2
Name: mitochondrial calcium uptake 2
Synonyms: 4833427E09Rik, 1110008L20Rik, Efha1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68514
VEGA: 14
Homologene: 12516
Or1m1
Name: olfactory receptor family 1 subfamily M member 1
Synonyms: MTPCR51, MOR132-1, GA_x6K02T2PVTD-12498544-12497603, Olfr24
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18322
HGNC: HGNC:8220
Homologene: 64896
5730455P16Rik
Name: RIKEN cDNA 5730455P16 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70591
Homologene: 11177
B3gnt7
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Synonyms: beta-3GnT7, C330001H22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227327
Homologene: 17049
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14732
Homologene: 7343
Ccdc28b
Name: coiled coil domain containing 28B
Synonyms: 1110002E08Rik, 1810010N17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66264
Homologene: 11509
N4bp2l2
Name: NEDD4 binding protein 2-like 2
Synonyms: 2700092H06Rik, zag1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381695
Homologene: 115380
Or51t4
Name: olfactory receptor family 51 subfamily T member 4
Synonyms: GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258357
Homologene: 27137
Or5b112
Name: olfactory receptor family 5 subfamily B member 112
Synonyms: GA_x6K02T2RE5P-3672907-3673839, MOR202-12, Olfr1466
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258689
HGNC: HGNC:8324
Homologene: 133677
Cyp4a14
Name: cytochrome P450, family 4, subfamily a, polypeptide 14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13119
Homologene: 134697
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68897
Homologene: 14133
Coq8a
Name: coenzyme Q8A
Synonyms: 4632432J16Rik, Cabc1, Adck3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67426
Homologene: 11345
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108682
Homologene: 68832
S100a7a
Name: S100 calcium binding protein A7A
Synonyms: S100A7f, LOC381493, S100a15, S100a17l1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381493
Homologene: 82417
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434113
Homologene: 113703
Zfp768
Name: zinc finger protein 768
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233890
Homologene: 11650
Ankrd49
Name: ankyrin repeat domain 49
Synonyms: Gbif
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56503
VEGA: 9
Homologene: 9787
Fam53b
Name: family with sequence similarity 53, member B
Synonyms: A930008G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77938
Homologene: 8776
P3r3urf
Name: Pik3r3 upstream reading frame
Synonyms: 1700042G07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67323
Homologene: 135820
Or1e31
Name: olfactory receptor family 1 subfamily E member 31
Synonyms: GA_x6K02T2P1NL-3951666-3950698, MOR135-24, MOR135-30_i, Olfr391-ps1, Olfr391-ps, Olfr391
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258236
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: LOC217602, EG639426, Gm9813, 4921506M07Rik, AU024163
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Gm47959
Name: predicted gene, 47959
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 83,000,782 bp
  • TTTTTTTTTTTTT to TTTTTTTTTTTTTTTTTT, chromosome 1 at 85,644,569 bp
  • A to G, chromosome 1 at 86,305,377 bp
  • T to C, chromosome 1 at 163,962,062 bp
  • T to A, chromosome 1 at 180,168,801 bp
  • C to A, chromosome 1 at 183,087,466 bp
  • T to C, chromosome 2 at 34,695,600 bp
  • T to C, chromosome 2 at 65,763,933 bp
  • T to C, chromosome 2 at 66,236,326 bp
  • A to T, chromosome 2 at 125,566,673 bp
  • C to T, chromosome 2 at 166,075,528 bp
  • T to C, chromosome 3 at 69,036,864 bp
  • A to G, chromosome 3 at 90,655,515 bp
  • A to T, chromosome 4 at 115,491,161 bp
  • A to G, chromosome 4 at 116,173,470 bp
  • T to C, chromosome 4 at 126,370,352 bp
  • T to C, chromosome 4 at 128,496,162 bp
  • T to A, chromosome 4 at 129,621,092 bp
  • T to C, chromosome 5 at 150,650,429 bp
  • A to T, chromosome 6 at 46,988,646 bp
  • G to A, chromosome 6 at 90,576,779 bp
  • T to C, chromosome 7 at 8,367,942 bp
  • T to A, chromosome 7 at 102,435,534 bp
  • T to C, chromosome 7 at 102,949,179 bp
  • A to T, chromosome 7 at 127,344,787 bp
  • T to C, chromosome 7 at 132,771,628 bp
  • C to T, chromosome 7 at 135,654,015 bp
  • A to G, chromosome 7 at 141,431,742 bp
  • T to C, chromosome 7 at 143,584,773 bp
  • T to C, chromosome 8 at 48,674,553 bp
  • G to A, chromosome 8 at 85,518,052 bp
  • TAA to TA, chromosome 9 at 14,782,540 bp
  • A to T, chromosome 9 at 18,754,878 bp
  • T to C, chromosome 11 at 69,436,182 bp
  • T to C, chromosome 11 at 73,799,164 bp
  • A to T, chromosome 11 at 80,364,925 bp
  • A to G, chromosome 11 at 107,984,022 bp
  • C to T, chromosome 11 at 121,204,670 bp
  • A to G, chromosome 12 at 13,243,863 bp
  • C to G, chromosome 12 at 57,576,339 bp
  • T to A, chromosome 13 at 11,669,987 bp
  • T to C, chromosome 14 at 50,653,584 bp
  • A to T, chromosome 14 at 57,971,781 bp
  • G to A, chromosome 15 at 6,644,856 bp
  • A to T, chromosome 15 at 73,533,291 bp
  • T to C, chromosome 16 at 36,782,298 bp
  • T to A, chromosome 16 at 36,917,963 bp
  • A to T, chromosome 17 at 25,383,536 bp
  • A to G, chromosome 19 at 6,322,291 bp
  • A to T, chromosome 19 at 13,341,739 bp
  • T to C, chromosome 19 at 55,076,335 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7125 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045327-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.