Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7241Btlr/Mmmh
Stock Number:
045348-MU
Citation ID:
RRID:MMRRC_045348-MU
Other Names:
R7241 (G1)
Major Collection:

Strain Information

B4galt5
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
Synonyms: 9430078I07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56336
HGNC: HGNC:928
Homologene: 3507
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: RAB5 effector protein, neurocrescin, rabaptin-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Drd5
Name: dopamine receptor D5
Synonyms: DRD1b, Drd-5, Gpcr1, Drd1b, D5R
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13492
HGNC: HGNC:3026
Homologene: 20216
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Washc2
Name: WASH complex subunit 2
Synonyms: C530005J20Rik, D6Wsu116e, Fam21
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28006
Homologene: 41686
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,801,628 bp
  • T to A, chromosome 1 at 135,851,706 bp
  • T to A, chromosome 1 at 136,468,753 bp
  • A to G, chromosome 2 at 32,558,064 bp
  • A to G, chromosome 2 at 76,953,206 bp
  • T to A, chromosome 2 at 84,829,989 bp
  • C to A, chromosome 2 at 86,594,154 bp
  • T to A, chromosome 2 at 120,441,529 bp
  • T to C, chromosome 2 at 125,306,495 bp
  • A to T, chromosome 2 at 155,991,552 bp
  • A to G, chromosome 2 at 167,306,697 bp
  • T to A, chromosome 3 at 20,065,392 bp
  • A to G, chromosome 3 at 93,395,954 bp
  • T to C, chromosome 3 at 96,559,675 bp
  • A to T, chromosome 4 at 15,991,190 bp
  • A to C, chromosome 4 at 45,029,340 bp
  • A to G, chromosome 4 at 115,602,302 bp
  • A to T, chromosome 4 at 116,807,518 bp
  • G to A, chromosome 4 at 139,443,414 bp
  • A to T, chromosome 4 at 155,269,059 bp
  • A to G, chromosome 5 at 38,320,536 bp
  • T to C, chromosome 5 at 112,473,480 bp
  • G to A, chromosome 5 at 114,245,100 bp
  • A to G, chromosome 5 at 140,462,188 bp
  • G to A, chromosome 6 at 41,675,308 bp
  • T to C, chromosome 6 at 108,517,620 bp
  • A to G, chromosome 6 at 116,208,207 bp
  • G to T, chromosome 7 at 16,857,805 bp
  • A to T, chromosome 7 at 21,162,612 bp
  • T to A, chromosome 7 at 23,952,466 bp
  • A to G, chromosome 7 at 30,528,721 bp
  • A to C, chromosome 7 at 80,254,163 bp
  • G to T, chromosome 7 at 97,417,088 bp
  • A to C, chromosome 7 at 100,407,050 bp
  • C to T, chromosome 7 at 114,237,356 bp
  • T to C, chromosome 7 at 119,943,633 bp
  • A to G, chromosome 7 at 120,246,961 bp
  • T to C, chromosome 7 at 140,945,720 bp
  • T to C, chromosome 8 at 24,898,494 bp
  • T to A, chromosome 8 at 24,950,986 bp
  • A to G, chromosome 8 at 110,895,897 bp
  • T to C, chromosome 9 at 71,724,770 bp
  • A to G, chromosome 9 at 108,563,437 bp
  • T to C, chromosome 9 at 114,492,956 bp
  • G to A, chromosome 10 at 69,706,814 bp
  • T to C, chromosome 10 at 80,387,257 bp
  • T to C, chromosome 10 at 82,287,042 bp
  • T to G, chromosome 10 at 90,512,837 bp
  • A to C, chromosome 10 at 103,215,973 bp
  • T to A, chromosome 11 at 59,177,134 bp
  • C to A, chromosome 11 at 70,939,989 bp
  • T to C, chromosome 11 at 73,907,232 bp
  • T to A, chromosome 11 at 83,351,105 bp
  • T to A, chromosome 11 at 121,069,882 bp
  • A to G, chromosome 12 at 40,794,860 bp
  • T to A, chromosome 12 at 85,805,239 bp
  • C to A, chromosome 12 at 115,386,702 bp
  • A to T, chromosome 13 at 11,665,913 bp
  • A to G, chromosome 13 at 18,125,289 bp
  • T to C, chromosome 13 at 43,153,017 bp
  • A to T, chromosome 13 at 54,991,020 bp
  • A to T, chromosome 13 at 99,411,280 bp
  • G to A, chromosome 13 at 103,334,000 bp
  • T to C, chromosome 14 at 31,264,939 bp
  • T to A, chromosome 14 at 50,362,141 bp
  • G to A, chromosome 14 at 56,131,342 bp
  • A to G, chromosome 14 at 57,479,997 bp
  • T to A, chromosome 15 at 55,062,141 bp
  • A to G, chromosome 15 at 78,607,045 bp
  • T to C, chromosome 15 at 100,518,587 bp
  • C to A, chromosome 16 at 3,848,247 bp
  • T to A, chromosome 16 at 30,352,277 bp
  • T to C, chromosome 16 at 97,436,798 bp
  • T to C, chromosome 16 at 97,795,741 bp
  • C to A, chromosome 17 at 11,854,861 bp
  • A to G, chromosome 17 at 33,579,928 bp
  • T to C, chromosome 17 at 56,315,193 bp
  • A to G, chromosome 18 at 25,060,352 bp
  • T to C, chromosome 19 at 6,081,913 bp
  • A to G, chromosome 19 at 7,614,581 bp
  • A to G, chromosome 19 at 9,009,031 bp
  • T to A, chromosome 19 at 40,090,568 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7241 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045348-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.