Strain Name:
C57BL/6J-MtgxR7264Btlr/Mmmh
Stock Number:
045354-MU
Citation ID:
RRID:MMRRC_045354-MU
Other Names:
R7264 (G1)
Major Collection:

Strain Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: tn, Hrs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Zfp42
Name: zinc finger protein 42
Synonyms: Rex-1, Rex1, Zfp-42
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22702
Homologene: 7601
Lhx9
Name: LIM homeobox protein 9
Synonyms: LH2B, 3110009O07Rik, Lhx9 alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16876
Homologene: 7816
Plcb4
Name: phospholipase C, beta 4
Synonyms: C230058B11Rik, A930039J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: wolframin, Wolfram syndrome 1 homolog (human)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22393
Homologene: 4380
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, 2610509D04Rik, Ggtb3, Bwf1, Alfy, Bchs
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Gstcd
Name: glutathione S-transferase, C-terminal domain containing
Synonyms: 4933434L15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67553
Homologene: 11693
Rev1
Name: REV1, DNA directed polymerase
Synonyms: REV1, Rev1l, 1110027I23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56210
Homologene: 32309
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 4631416I11Rik, 2310061P20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70797
Homologene: 19076
Ankle2
Name: ankyrin repeat and LEM domain containing 2
Synonyms: 1110001J12Rik, D5Ertd585e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71782
Homologene: 35424
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17847
Homologene: 40978
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 1810059M14Rik, 2310058O09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100072
Homologene: 18942
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Mrps36
Name: mitochondrial ribosomal protein S36
Synonyms: 1110018B13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66128
Homologene: 11924
Hrob
Name: homologous recombination factor with OB-fold
Synonyms: BC030867
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217216
Homologene: 69368
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237553
Homologene: 75007
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: Dnahc1, G1-415-19, MDHC7, ferf1, B230373P09Rik, E030034C22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: Cav1.2, Cchl1a1, D930026N18Rik, (alpha)1 subunit, L-type Cav1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: NMF355, nmf355, Clc1, Clc-1, SMCC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: A2mr, CD91, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: Heatr7b2, 4930455B06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Vmn1r204
Name: vomeronasal 1 receptor 204
Synonyms: Gm11301
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 632793
Homologene: 110880
Fbxl4
Name: F-box and leucine-rich repeat protein 4
Synonyms: FBL4, FBL5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269514
Homologene: 8128
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, lubricin, SZP, DOL54
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms: 2310066H07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50798
Homologene: 3996
Or52z13
Name: olfactory receptor family 52 subfamily Z member 13
Synonyms: Olfr618, MOR31-9, GA_x6K02T2PBJ9-6320148-6321104
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259049
Homologene: 72966
Igbp1b
Name: immunoglobulin (CD79A) binding protein 1b
Synonyms: alpha4-b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50540
Homologene: 75049
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Plch2
Name: phospholipase C, eta 2
Synonyms: Plcl4, A930027K05Rik, PLCeta2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269615
Homologene: 85172
Spopfm1
Name: speckle-type BTB/POZ protein family member 1
Synonyms: Gm4778
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212727
Adora3
Name: adenosine A3 receptor
Synonyms: A3R, Gpcr 2, ARA3, 1700001D09Rik, AA3R, 4930578J19Rik, A3AR
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11542
HGNC: HGNC:268
Homologene: 550
Grep1
Name: glycine rich extracellular protein 1
Synonyms: 1520401A03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320309
Cep250
Name: centrosomal protein 250
Synonyms: Cep2, B230210E21Rik, Inmp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Serinc2
Name: serine incorporator 2
Synonyms: 2310004K20Rik, Tde2l, FKSG84, TDE2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230779
Homologene: 27797
Stxbp6
Name: syntaxin binding protein 6 (amisyn)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217517
Homologene: 8579
C2cd2
Name: C2 calcium-dependent domain containing 2
Synonyms: 5830404H04Rik, ORF25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207781
VEGA: 16
HGNC: HGNC:1266
Homologene: 18368
Arhgef16
Name: Rho guanine nucleotide exchange factor 16
Synonyms: Neuroblastoma
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230972
Homologene: 82484
Zfp957
Name: zinc finger protein 957
Synonyms: AU017455
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105590
Scarf2
Name: scavenger receptor class F, member 2
Synonyms: Srec2, SREC-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224024
VEGA: 16
Homologene: 17817
Catsper4
Name: cation channel, sperm associated 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329954
Homologene: 18638
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: LOC380650, Gm10937, C030032C09Rik, E530015N03Rik, AIDA-1b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Tmem74
Name: transmembrane protein 74
Synonyms: B230382K22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239408
VEGA: 15
Homologene: 17684
Slpi
Name: secretory leukocyte peptidase inhibitor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20568
Homologene: 2305
Ttc33
Name: tetratricopeptide repeat domain 33
Synonyms: 2900001O04Rik, 2410099M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67515
Homologene: 8226
Gm8257
Name: predicted pseudogene 8257
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 666725
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 38,085,601 bp
  • T to C, chromosome 1 at 53,518,814 bp
  • T to C, chromosome 1 at 138,832,751 bp
  • T to A, chromosome 1 at 150,454,067 bp
  • A to T, chromosome 2 at 135,965,080 bp
  • A to G, chromosome 2 at 155,979,151 bp
  • C to A, chromosome 2 at 164,356,402 bp
  • T to C, chromosome 2 at 181,351,861 bp
  • C to T, chromosome 3 at 94,265,738 bp
  • C to A, chromosome 3 at 105,904,825 bp
  • A to G, chromosome 3 at 114,185,599 bp
  • A to T, chromosome 3 at 127,563,569 bp
  • C to T, chromosome 3 at 133,084,779 bp
  • T to C, chromosome 4 at 22,386,145 bp
  • T to A, chromosome 4 at 44,042,175 bp
  • C to T, chromosome 4 at 130,258,259 bp
  • TTCTC to TTC, chromosome 4 at 134,227,112 bp
  • A to G, chromosome 4 at 151,453,399 bp
  • C to T, chromosome 4 at 154,280,930 bp
  • T to A, chromosome 4 at 154,998,967 bp
  • T to A, chromosome 5 at 3,755,739 bp
  • T to C, chromosome 5 at 32,967,745 bp
  • A to G, chromosome 5 at 36,967,846 bp
  • C to A, chromosome 5 at 101,855,523 bp
  • G to A, chromosome 5 at 110,237,823 bp
  • T to C, chromosome 5 at 144,814,523 bp
  • T to A, chromosome 5 at 146,514,662 bp
  • C to A, chromosome 6 at 42,298,838 bp
  • T to C, chromosome 6 at 118,602,195 bp
  • T to C, chromosome 6 at 138,658,110 bp
  • T to A, chromosome 7 at 103,597,748 bp
  • A to G, chromosome 8 at 35,785,766 bp
  • T to C, chromosome 8 at 43,296,275 bp
  • A to T, chromosome 9 at 62,745,908 bp
  • T to A, chromosome 10 at 90,512,870 bp
  • C to T, chromosome 10 at 114,800,871 bp
  • C to T, chromosome 10 at 127,592,093 bp
  • A to G, chromosome 11 at 23,333,566 bp
  • T to A, chromosome 11 at 102,255,596 bp
  • G to T, chromosome 11 at 120,474,313 bp
  • T to C, chromosome 12 at 44,901,999 bp
  • A to G, chromosome 12 at 102,390,115 bp
  • A to G, chromosome 13 at 22,556,997 bp
  • A to G, chromosome 13 at 100,739,199 bp
  • A to T, chromosome 14 at 31,269,894 bp
  • T to A, chromosome 14 at 44,656,360 bp
  • A to G, chromosome 14 at 79,213,640 bp
  • A to G, chromosome 15 at 4,921,362 bp
  • C to T, chromosome 15 at 5,217,237 bp
  • G to A, chromosome 15 at 43,867,468 bp
  • G to T, chromosome 16 at 17,803,290 bp
  • C to A, chromosome 16 at 97,876,219 bp
  • A to G, chromosome 17 at 23,712,334 bp
  • A to T, chromosome 17 at 67,743,297 bp
  • A to G, chromosome 18 at 67,820,355 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7264 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045354-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.