Loading...

Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7283Btlr/Mmmh
Stock Number:
045361-MU
Citation ID:
RRID:MMRRC_045361-MU
Other Names:
R7283 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Avpr1b
Name: arginine vasopressin receptor 1B
Synonyms: V3/V1b pituitary vasopressin receptor, V3/V1b, V1bR, AVPR3, V1BR, VPR3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26361
HGNC: HGNC:896
Homologene: 22678

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Abce1
Name: ATP-binding cassette, sub-family E member 1
Synonyms: RNS4l (Eye), Oabp, Rnaseli
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24015
HGNC: HGNC:69
Homologene: 2205

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Spag7
Name: sperm associated antigen 7
Synonyms: FSA-1, Fsa1l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216873
Homologene: 3595

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Sptlc1
Name: serine palmitoyltransferase, long chain base subunit 1
Synonyms: Lcb1, Spt1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268656
VEGA: 13
Homologene: 4681

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Prkca
Name: protein kinase C, alpha
Synonyms: Pkca
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18750
HGNC: HGNC:9393
Homologene: 55679

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Stk17b
Name: serine/threonine kinase 17b (apoptosis-inducing)
Synonyms: Drak2, 3110009A03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98267
Homologene: 31231

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 53,757,515 bp
  • A to T, chromosome 1 at 54,729,796 bp
  • G to C, chromosome 1 at 60,237,151 bp
  • C to T, chromosome 1 at 119,682,531 bp
  • A to G, chromosome 1 at 131,609,731 bp
  • A to G, chromosome 1 at 136,073,708 bp
  • A to T, chromosome 1 at 194,644,883 bp
  • T to A, chromosome 2 at 32,815,014 bp
  • T to C, chromosome 2 at 66,208,718 bp
  • A to T, chromosome 2 at 86,483,139 bp
  • T to C, chromosome 2 at 121,379,452 bp
  • A to T, chromosome 3 at 38,889,693 bp
  • T to C, chromosome 3 at 97,758,882 bp
  • T to A, chromosome 3 at 98,742,357 bp
  • T to C, chromosome 3 at 142,311,980 bp
  • G to A, chromosome 4 at 13,846,935 bp
  • T to A, chromosome 4 at 48,392,526 bp
  • T to C, chromosome 4 at 59,514,384 bp
  • T to A, chromosome 4 at 142,031,783 bp
  • A to G, chromosome 5 at 72,529,050 bp
  • A to C, chromosome 5 at 121,649,475 bp
  • A to C, chromosome 5 at 123,613,794 bp
  • T to A, chromosome 5 at 137,905,556 bp
  • A to T, chromosome 5 at 138,192,882 bp
  • G to C, chromosome 5 at 143,287,738 bp
  • A to G, chromosome 6 at 68,835,077 bp
  • C to A, chromosome 6 at 116,227,418 bp
  • T to C, chromosome 6 at 124,025,955 bp
  • A to T, chromosome 6 at 128,784,257 bp
  • T to A, chromosome 6 at 148,824,481 bp
  • T to C, chromosome 7 at 15,972,500 bp
  • T to C, chromosome 7 at 26,766,914 bp
  • T to C, chromosome 7 at 30,305,812 bp
  • T to C, chromosome 7 at 97,451,486 bp
  • G to T, chromosome 7 at 104,733,593 bp
  • G to A, chromosome 8 at 13,319,605 bp
  • C to A, chromosome 8 at 79,685,256 bp
  • A to G, chromosome 8 at 95,071,579 bp
  • A to C, chromosome 9 at 20,260,259 bp
  • G to A, chromosome 9 at 35,188,929 bp
  • A to G, chromosome 9 at 119,664,779 bp
  • G to A, chromosome 10 at 82,291,297 bp
  • A to G, chromosome 11 at 23,867,394 bp
  • A to T, chromosome 11 at 67,201,844 bp
  • A to T, chromosome 11 at 70,665,313 bp
  • T to C, chromosome 11 at 73,964,808 bp
  • A to T, chromosome 11 at 77,010,696 bp
  • A to G, chromosome 11 at 78,274,828 bp
  • C to T, chromosome 11 at 94,357,047 bp
  • C to T, chromosome 11 at 108,340,645 bp
  • A to G, chromosome 11 at 109,611,311 bp
  • A to G, chromosome 12 at 4,203,563 bp
  • A to T, chromosome 12 at 70,216,568 bp
  • A to C, chromosome 12 at 103,672,432 bp
  • A to T, chromosome 13 at 23,855,848 bp
  • T to C, chromosome 13 at 53,344,878 bp
  • A to G, chromosome 13 at 54,552,691 bp
  • G to A, chromosome 13 at 65,195,538 bp
  • G to A, chromosome 13 at 74,673,784 bp
  • A to G, chromosome 14 at 86,866,584 bp
  • A to G, chromosome 15 at 4,516,919 bp
  • G to A, chromosome 15 at 38,501,408 bp
  • A to G, chromosome 15 at 44,503,280 bp
  • A to T, chromosome 15 at 74,580,663 bp
  • G to A, chromosome 16 at 3,947,877 bp
  • A to G, chromosome 16 at 15,717,764 bp
  • A to T, chromosome 16 at 59,074,192 bp
  • A to T, chromosome 17 at 36,882,662 bp
  • A to G, chromosome 17 at 50,047,441 bp
  • A to G, chromosome 17 at 80,297,259 bp
  • A to G, chromosome 18 at 5,214,712 bp
  • A to G, chromosome 18 at 31,316,839 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7283 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045361-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.