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Strain Name:
C57BL/6J-MtgxR7347Btlr/Mmmh
Stock Number:
045374-MU
Citation ID:
RRID:MMRRC_045374-MU
Other Names:
R7347 (G1)
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: NP2, Npn-2, Npn2, NP-2, 1110048P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Slc6a1
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms: XT-1, Gabt, Xtrp1, Gat1, Gabt1, GAT-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232333
Homologene: 2290
Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: F4/80, DD7A5-7, TM7LN3, EGF-TM7, Ly71, Emr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Atp5mf
Name: ATP synthase membrane subunit f
Synonyms: hypothetical protein, clone:2-31, 1110019H14Rik, Atp5j2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57423
HGNC: HGNC:848
Homologene: 3594
Spry2
Name: sprouty RTK signaling antagonist 2
Synonyms: sprouty2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24064
VEGA: 14
Homologene: 4267
Mad1l1
Name: MAD1 mitotic arrest deficient 1-like 1
Synonyms: Mad1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17120
HGNC: HGNC:6762
Homologene: 74500
Glrx3
Name: glutaredoxin 3
Synonyms: PKC interacting cousin of thioredoxin, PICOT, Txnl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30926
Homologene: 4769
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 24,179,403 bp
  • A to T, chromosome 1 at 26,684,467 bp
  • C to A, chromosome 1 at 34,587,902 bp
  • G to T, chromosome 1 at 44,059,496 bp
  • A to T, chromosome 1 at 51,751,254 bp
  • C to T, chromosome 1 at 62,745,504 bp
  • T to C, chromosome 1 at 74,291,279 bp
  • T to A, chromosome 1 at 84,159,129 bp
  • A to C, chromosome 1 at 93,281,736 bp
  • C to T, chromosome 1 at 111,861,573 bp
  • T to A, chromosome 1 at 146,902,086 bp
  • A to G, chromosome 2 at 23,133,389 bp
  • A to T, chromosome 2 at 58,017,193 bp
  • T to C, chromosome 2 at 85,689,837 bp
  • T to C, chromosome 2 at 88,897,271 bp
  • T to C, chromosome 2 at 89,482,455 bp
  • T to A, chromosome 2 at 103,463,298 bp
  • T to G, chromosome 2 at 103,567,412 bp
  • G to A, chromosome 2 at 120,666,534 bp
  • T to C, chromosome 2 at 136,060,958 bp
  • T to C, chromosome 2 at 165,687,666 bp
  • G to A, chromosome 3 at 65,376,531 bp
  • A to T, chromosome 3 at 87,869,681 bp
  • G to T, chromosome 3 at 105,078,412 bp
  • A to G, chromosome 3 at 108,042,373 bp
  • T to G, chromosome 4 at 48,051,290 bp
  • A to G, chromosome 4 at 88,557,983 bp
  • A to T, chromosome 4 at 129,294,306 bp
  • T to C, chromosome 4 at 137,402,606 bp
  • T to C, chromosome 4 at 156,222,671 bp
  • C to T, chromosome 5 at 75,183,098 bp
  • T to C, chromosome 5 at 103,968,750 bp
  • C to T, chromosome 5 at 140,144,044 bp
  • C to T, chromosome 5 at 143,202,390 bp
  • T to C, chromosome 5 at 145,188,485 bp
  • T to A, chromosome 5 at 147,580,381 bp
  • T to A, chromosome 6 at 4,694,106 bp
  • T to A, chromosome 6 at 5,784,530 bp
  • G to C, chromosome 6 at 72,616,278 bp
  • T to C, chromosome 6 at 114,311,818 bp
  • G to A, chromosome 7 at 4,921,818 bp
  • A to G, chromosome 7 at 9,986,814 bp
  • C to T, chromosome 7 at 10,748,501 bp
  • A to C, chromosome 7 at 15,834,646 bp
  • C to T, chromosome 7 at 28,299,111 bp
  • G to A, chromosome 7 at 35,429,928 bp
  • A to G, chromosome 7 at 35,485,692 bp
  • T to C, chromosome 7 at 112,382,151 bp
  • A to T, chromosome 7 at 120,991,728 bp
  • C to A, chromosome 7 at 137,459,286 bp
  • A to C, chromosome 8 at 110,600,362 bp
  • A to G, chromosome 9 at 19,537,099 bp
  • T to C, chromosome 9 at 21,108,034 bp
  • A to T, chromosome 9 at 26,829,003 bp
  • T to A, chromosome 9 at 32,733,032 bp
  • T to C, chromosome 9 at 51,849,035 bp
  • A to G, chromosome 9 at 53,375,896 bp
  • G to T, chromosome 9 at 62,489,372 bp
  • T to A, chromosome 9 at 103,282,646 bp
  • T to G, chromosome 9 at 108,682,458 bp
  • G to A, chromosome 10 at 126,009,966 bp
  • A to G, chromosome 11 at 60,477,961 bp
  • C to G, chromosome 11 at 77,017,085 bp
  • C to T, chromosome 11 at 86,139,103 bp
  • G to T, chromosome 11 at 101,185,268 bp
  • T to A, chromosome 11 at 101,569,321 bp
  • T to G, chromosome 12 at 21,229,457 bp
  • C to A, chromosome 12 at 30,012,261 bp
  • T to C, chromosome 12 at 111,540,290 bp
  • T to C, chromosome 13 at 49,515,078 bp
  • T to C, chromosome 13 at 50,245,744 bp
  • T to C, chromosome 13 at 104,050,847 bp
  • T to G, chromosome 14 at 105,893,512 bp
  • C to A, chromosome 15 at 31,486,359 bp
  • C to A, chromosome 16 at 23,067,787 bp
  • G to T, chromosome 16 at 33,434,790 bp
  • G to T, chromosome 16 at 62,919,523 bp
  • A to G, chromosome 17 at 8,967,462 bp
  • A to C, chromosome 17 at 46,250,827 bp
  • C to A, chromosome 17 at 57,223,215 bp
  • T to C, chromosome 17 at 57,420,441 bp
  • T to A, chromosome 18 at 90,591,375 bp
  • G to A, chromosome 19 at 11,590,073 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7347 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045374-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.