Strain Name:
C57BL/6J-MtgxR7345Btlr/Mmmh
Stock Number:
045379-MU
Citation ID:
RRID:MMRRC_045379-MU
Other Names:
R7345 (G1)
Major Collection:

Strain Information

Mapk8
Name: mitogen-activated protein kinase 8
Synonyms: Prkm8, JNK1, c-Jun N-terminal kinase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26419
HGNC: HGNC:6881
Homologene: 56760
Map2k6
Name: mitogen-activated protein kinase kinase 6
Synonyms: SAPKK3, MAP kinase kinase 6, Prkmk6, MKK6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26399
HGNC: HGNC:6846
Homologene: 55686
Anks3
Name: ankyrin repeat and sterile alpha motif domain containing 3
Synonyms: 2700067D09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72615
VEGA: 16
Homologene: 12475
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227699
Homologene: 45683
Stx1a
Name: syntaxin 1A (brain)
Synonyms: HPC-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20907
Homologene: 37941
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21853
Homologene: 31206
Med13l
Name: mediator complex subunit 13-like
Synonyms: 2210413I17Rik, Trap240L, 6330591G05Rik, 9030618F05Rik, Thrap2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: LOC237877, C130052G03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237877
Homologene: 32611
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfat1, Zfp406, LOC380993
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Spred2
Name: sprouty-related EVH1 domain containing 2
Synonyms: Spred-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114716
Homologene: 24918
Dcc
Name: DCC netrin 1 receptor
Synonyms: C030036D22Rik, deleted in colorectal carcinoma, Igdcc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58996
Homologene: 104145
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: ct, Get1, Som
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230824
Homologene: 18864
Poc5
Name: POC5 centriolar protein
Synonyms: 1200014M14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67463
VEGA: 13
Homologene: 12141
Sec31a
Name: SEC31 homolog A, COPII coat complex component
Synonyms: Sec31l1, 1810024J13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69162
Homologene: 42056
Pcdhb18
Name: protocadherin beta 18
Synonyms: PcdhbR, Pcdhb9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93889
Homologene: 137649
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Soat2
Name: sterol O-acyltransferase 2
Synonyms: D15Wsu97e, ACAT2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223920
Homologene: 68355
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 674895
Homologene: 130947
Slc1a5
Name: solute carrier family 1 (neutral amino acid transporter), member 5
Synonyms: ASCT2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20514
Homologene: 21155
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64580
Homologene: 11208
Il1a
Name: interleukin 1 alpha
Synonyms: Il-1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16175
HGNC: HGNC:5991
Homologene: 480
Fbxo24
Name: F-box protein 24
Synonyms: 4933422D21Rik, Fbx24
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71176
Homologene: 14131
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: LOC380917, 5031414D18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Dcaf10
Name: DDB1 and CUL4 associated factor 10
Synonyms: Wdr32
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242418
Homologene: 32581
Cep126
Name: centrosomal protein 126
Synonyms: AK129341
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234915
VEGA: 9
Homologene: 28313
Serpinh1
Name: serine (or cysteine) peptidase inhibitor, clade H, member 1
Synonyms: gp46, Serpinh2, Cbp1, Hsp47, colligin, J6, Cbp2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12406
HGNC: HGNC:1546
Homologene: 20331
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
B3galnt2
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2
Synonyms: A930105D20Rik, D230016N13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97884
VEGA: 13
Homologene: 17595
Speg
Name: SPEG complex locus
Synonyms: SPEGalpha, SPEG, D1Bwg1450e, Apeg1, SPEGbeta, BPEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228846
Homologene: 18598
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Or8g23
Name: olfactory receptor family 8 subfamily G member 23
Synonyms: GA_x6K02T2PVTD-32756567-32755632, Olfr937, MOR171-24
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258431
VEGA: 9
HGNC: HGNC:8484
Homologene: 27167
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Klc3
Name: kinesin light chain 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232943
Homologene: 14899
Nrm
Name: nurim (nuclear envelope membrane protein)
Synonyms: 2610307M02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106582
HGNC: HGNC:8003
Homologene: 38294
P2ry1
Name: purinergic receptor P2Y, G-protein coupled 1
Synonyms: P2Y1, P2y1r, P2Y1 receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18441
HGNC: HGNC:8539
Homologene: 1926
Ipo4
Name: importin 4
Synonyms: 8430408O15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75751
Homologene: 5835
Or9s18
Name: olfactory receptor family 9 subfamily S member 18
Synonyms: MOR209-1, GA_x6K02T2PB7A-3051266-3052192, Olfr466
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258816
Homologene: 72032
Or5p78
Name: olfactory receptor family 5 subfamily P member 78
Synonyms: MOR204-23, GA_x6K02T2PBJ9-10942040-10942984, Olfr506
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258215
Homologene: 133672
B430305J03Rik
Name: RIKEN cDNA B430305J03 gene
Type: Gene
Species: Mouse
Chromosome: 3
Cd163
Name: CD163 antigen
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93671
HGNC: HGNC:1631
Homologene: 128811
Or8g24
Name: olfactory receptor family 8 subfamily G member 24
Synonyms: Olfr938, GA_x6K02T2PVTD-32774646-32773699, MOR171-25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258430
VEGA: 9
Olfml2a
Name: olfactomedin-like 2A
Synonyms: 4932431K08Rik, photomedin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241327
Homologene: 35248
Cimip2b
Name: ciliary microtubule inner protein 2B
Synonyms: Fam166b, 4833436C18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329831
Homologene: 52229
Stac2
Name: SH3 and cysteine rich domain 2
Synonyms: 24b2/STAC2, 24b2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217154
Homologene: 17131
Tsen34
Name: tRNA splicing endonuclease subunit 34
Synonyms: Leng5, 0610027F08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66078
Homologene: 44182
Zfp551
Name: zinc finger protein 551
Synonyms: 9630004E07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 619331
Homologene: 64631
Gm21190
Name: predicted gene, 21190
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100861755
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,384,835 bp
  • T to C, chromosome 2 at 30,340,601 bp
  • C to A, chromosome 2 at 38,960,127 bp
  • C to A, chromosome 2 at 129,304,773 bp
  • C to T, chromosome 2 at 158,217,209 bp
  • T to C, chromosome 3 at 61,003,674 bp
  • T to C, chromosome 3 at 61,364,118 bp
  • C to T, chromosome 3 at 125,714,659 bp
  • T to C, chromosome 4 at 43,173,966 bp
  • T to C, chromosome 4 at 43,428,022 bp
  • T to C, chromosome 4 at 45,342,583 bp
  • T to C, chromosome 4 at 88,628,179 bp
  • C to T, chromosome 4 at 135,546,246 bp
  • C to A, chromosome 4 at 154,267,315 bp
  • T to C, chromosome 5 at 15,527,904 bp
  • T to C, chromosome 5 at 77,349,119 bp
  • T to C, chromosome 5 at 100,385,270 bp
  • T to A, chromosome 5 at 110,303,903 bp
  • T to C, chromosome 5 at 118,742,760 bp
  • T to A, chromosome 5 at 135,037,188 bp
  • G to T, chromosome 5 at 137,621,261 bp
  • A to T, chromosome 6 at 124,318,938 bp
  • T to C, chromosome 7 at 3,695,615 bp
  • G to A, chromosome 7 at 12,416,595 bp
  • T to A, chromosome 7 at 16,796,160 bp
  • G to A, chromosome 7 at 19,394,889 bp
  • A to C, chromosome 7 at 99,346,356 bp
  • A to T, chromosome 7 at 105,703,967 bp
  • C to T, chromosome 7 at 108,613,063 bp
  • A to T, chromosome 7 at 125,645,670 bp
  • A to G, chromosome 9 at 8,099,816 bp
  • A to G, chromosome 9 at 39,060,579 bp
  • G to A, chromosome 9 at 39,078,334 bp
  • C to T, chromosome 10 at 128,249,754 bp
  • T to C, chromosome 11 at 19,924,958 bp
  • T to C, chromosome 11 at 80,096,006 bp
  • G to A, chromosome 11 at 97,466,478 bp
  • A to C, chromosome 11 at 98,042,613 bp
  • A to T, chromosome 11 at 110,492,908 bp
  • G to T, chromosome 11 at 115,786,256 bp
  • C to T, chromosome 13 at 13,980,480 bp
  • A to C, chromosome 13 at 65,152,743 bp
  • A to G, chromosome 13 at 96,396,796 bp
  • T to A, chromosome 14 at 14,955,503 bp
  • A to T, chromosome 14 at 33,408,111 bp
  • C to T, chromosome 14 at 55,635,531 bp
  • A to G, chromosome 14 at 75,042,353 bp
  • A to T, chromosome 15 at 68,105,043 bp
  • A to G, chromosome 15 at 102,162,578 bp
  • A to G, chromosome 16 at 4,955,910 bp
  • G to A, chromosome 17 at 32,486,779 bp
  • A to G, chromosome 17 at 35,864,584 bp
  • T to C, chromosome 18 at 37,491,923 bp
  • A to G, chromosome 18 at 71,378,824 bp
  • A to G, chromosome 18 at 74,708,024 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7345 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045379-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.