Strain Name:
C57BL/6J-MtgxR7258Btlr/Mmmh
Stock Number:
045386-MU
Citation ID:
RRID:MMRRC_045386-MU
Other Names:
R7258 (G1)
Major Collection:

Strain Information

Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Kdm5b
Name: lysine demethylase 5B
Synonyms: PLU-1, 2010009J12Rik, Plu1, Rb-Bp2, 2210016I17Rik, D1Ertd202e, Jarid1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Nms
Name: neuromedin S
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433292
Homologene: 67775
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: NBL2, 4.1G, D10Ertd398e, Epb4.1l2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Ssc4d
Name: scavenger receptor cysteine rich family, 4 domains
Synonyms: C330016E03Rik, Srcrb4d
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109267
Homologene: 34137
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Dnmt3b
Name: DNA methyltransferase 3B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13436
HGNC: HGNC:2979
Homologene: 56000
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Ddx54
Name: DEAD box helicase 54
Synonyms: APR-5, DP97, 2410015A15Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71990
Homologene: 5590
Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Synonyms: Pir121, 6430511D02Rik, 1500004I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76884
Homologene: 7936
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Snorc
Name: secondary ossification center associated regulator of chondrocyte maturation
Synonyms: Snorc, 3110079O15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73234
Homologene: 19210
Zfp653
Name: zinc finger protein 653
Synonyms: E430039K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319601
VEGA: 9
Homologene: 16346
L1td1
Name: LINE-1 type transposase domain containing 1
Synonyms: ECAT11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381591
Homologene: 135709
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Gipc2
Name: GIPC PDZ domain containing family, member 2
Synonyms: 2200002N01Rik, Semcap2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54120
Homologene: 22994
Steap3
Name: STEAP family member 3
Synonyms: 1010001D01Rik, pHyde
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68428
Homologene: 10084
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly-51, Ly51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246177
Homologene: 27996
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Gbp5
Name: guanylate binding protein 5
Synonyms: 5330409J06Rik, Gbp5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229898
Homologene: 14183
Ccr5
Name: C-C motif chemokine receptor 5
Synonyms: CD195, Cmkbr5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12774
HGNC: HGNC:1606
Homologene: 37325
Hrc
Name: histidine rich calcium binding protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15464
HGNC: HGNC:5178
Homologene: 137234
Abcc12
Name: ATP-binding cassette, sub-family C member 12
Synonyms: MRP9, 4930467B22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244562
Homologene: 57211
Uba5
Name: ubiquitin-like modifier activating enzyme 5
Synonyms: 5730525G14Rik, Ube1dc1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66663
Homologene: 11738
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, 2700017I06Rik, Gm13190
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: mGluR5, Gprc1e, 6430542K11Rik, Glu5R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Ly86
Name: lymphocyte antigen 86
Synonyms: MD1, MD-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17084
VEGA: 13
Homologene: 48274
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666060
Homologene: 8939
Sox30
Name: SRY (sex determining region Y)-box 30
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214105
Homologene: 34027
Cdhr18
Name: cadherin related family member 18
Synonyms: LOC238939, Gm281
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 238939
Homologene: 141164
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93880
HGNC: HGNC:8689
Homologene: 87124
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 435845
Homologene: 78847
Iftap
Name: intraflagellar transport associated protein
Synonyms: NWC, B230118H07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68170
Homologene: 16348
Zfp777
Name: zinc finger protein 777
Synonyms: 2500002G23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72306
Homologene: 56721
Slc41a1
Name: solute carrier family 41, member 1
Synonyms: B230315F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98396
Homologene: 14871
Defa35
Name: defensin, alpha, 35
Synonyms: ENSMUSG00000061845, OTTMUSG00000018258, Gm10104
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041688
Homologene: 113382
Or1j4
Name: olfactory receptor family 1 subfamily J member 4
Synonyms: GA_x6K02T2NLDC-33544602-33545540, MOR136-13, Olfr350
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258620
HGNC: HGNC:8211
Homologene: 64897
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Tgm4
Name: transglutaminase 4 (prostate)
Synonyms: experimental autoimmune prostatitis antigen 1, Eapa1, 9530008N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331046
Homologene: 20689
Ugt2b36
Name: UDP glucuronosyltransferase 2 family, polypeptide B36
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231396
Homologene: 128251
Or6c69
Name: olfactory receptor family 6 subfamily C member 69
Synonyms: GA_x6K02T2PULF-11590830-11589892, MOR113-1, Olfr816
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258667
Homologene: 133584
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: Gpd-1, Gpd1, G6pd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71481
Homologene: 11849
Zfp936
Name: zinc finger protein 936
Synonyms: EG435970, I1C0022H11Rik, Gm9272
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668620
Or8k37
Name: olfactory receptor family 8 subfamily K member 37
Synonyms: GA_x6K02T2Q125-48121788-48120847, MOR192-3, MOR192-2, Olfr1084
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258235
Homologene: 104285
Stx5a
Name: syntaxin 5A
Synonyms: syntaxin 5, 0610031F24Rik, D19Ertd627e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56389
Homologene: 2381
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TbetaR-II, TbetaRII, 1110020H15Rik, TBR-II
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Utp14b
Name: UTP14B small subunit processome component
Synonyms: jsd, 4932411L21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 195434
Homologene: 78703
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: PC3, prohormone convertase 1/3, Nec-1, Nec1, PC1, SPC3, Phpp-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Or51af1
Name: olfactory receptor family 51 subfamily AF member 1
Synonyms: GA_x6K02T2PBJ9-6207735-6206776, MOR9-1, Olfr609
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259086
Homologene: 64952
Snrpa1
Name: small nuclear ribonucleoprotein polypeptide A'
Synonyms: U2 snRNP-A', 1500015N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68981
Homologene: 2325
Plekhg2
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Synonyms: Clg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101497
Homologene: 16341
Abhd14b
Name: abhydrolase domain containing 14b
Synonyms: 1810013B01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76491
Homologene: 9125
Or6b3
Name: olfactory receptor family 6 subfamily B member 3
Synonyms: GA_x6K02T2R7CC-81245243-81246181, MOR103-2, Olfr1414
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 259041
Homologene: 88368
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434113
Homologene: 113703
Gm6309
Name: predicted gene 6309
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622306
Homologene: 86127
4933402J07Rik
Name: RIKEN cDNA 4933402J07 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330820
Homologene: 51633
Or1e31
Name: olfactory receptor family 1 subfamily E member 31
Synonyms: GA_x6K02T2P1NL-3951666-3950698, MOR135-24, MOR135-30_i, Olfr391-ps1, Olfr391-ps, Olfr391
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258236
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 14,903,249 bp
  • A to G, chromosome 1 at 38,946,970 bp
  • A to G, chromosome 1 at 72,651,727 bp
  • T to A, chromosome 1 at 78,664,974 bp
  • A to C, chromosome 1 at 87,475,067 bp
  • A to T, chromosome 1 at 92,511,176 bp
  • A to G, chromosome 1 at 120,243,986 bp
  • T to A, chromosome 1 at 131,842,042 bp
  • A to C, chromosome 1 at 134,621,021 bp
  • A to G, chromosome 1 at 150,715,823 bp
  • A to T, chromosome 1 at 157,157,700 bp
  • A to T, chromosome 2 at 4,300,953 bp
  • T to A, chromosome 2 at 36,850,340 bp
  • T to C, chromosome 2 at 76,139,906 bp
  • T to A, chromosome 2 at 86,639,001 bp
  • T to C, chromosome 2 at 101,610,592 bp
  • T to A, chromosome 2 at 153,683,599 bp
  • A to T, chromosome 3 at 127,724,466 bp
  • A to C, chromosome 3 at 129,332,075 bp
  • T to A, chromosome 3 at 142,506,781 bp
  • T to C, chromosome 3 at 152,165,715 bp
  • C to A, chromosome 4 at 45,269,974 bp
  • C to T, chromosome 4 at 98,736,864 bp
  • A to T, chromosome 4 at 108,656,954 bp
  • T to C, chromosome 4 at 149,996,362 bp
  • A to G, chromosome 5 at 86,271,413 bp
  • A to T, chromosome 5 at 87,080,903 bp
  • T to G, chromosome 5 at 120,620,747 bp
  • G to T, chromosome 5 at 135,963,087 bp
  • A to T, chromosome 5 at 146,168,296 bp
  • T to C, chromosome 6 at 48,025,797 bp
  • T to A, chromosome 7 at 8,377,849 bp
  • T to C, chromosome 7 at 28,364,778 bp
  • T to A, chromosome 7 at 43,190,379 bp
  • T to A, chromosome 7 at 45,336,296 bp
  • T to C, chromosome 7 at 66,070,143 bp
  • A to T, chromosome 7 at 88,074,706 bp
  • G to C, chromosome 7 at 103,492,589 bp
  • A to T, chromosome 8 at 21,065,229 bp
  • T to A, chromosome 8 at 47,842,999 bp
  • T to C, chromosome 8 at 72,750,208 bp
  • T to C, chromosome 8 at 86,560,857 bp
  • A to C, chromosome 8 at 87,586,177 bp
  • T to C, chromosome 9 at 22,065,820 bp
  • A to T, chromosome 9 at 104,062,933 bp
  • A to G, chromosome 9 at 106,450,219 bp
  • A to T, chromosome 9 at 116,129,830 bp
  • A to G, chromosome 9 at 123,062,491 bp
  • A to T, chromosome 9 at 124,125,274 bp
  • G to A, chromosome 10 at 25,484,287 bp
  • T to G, chromosome 10 at 100,499,108 bp
  • T to A, chromosome 10 at 129,912,287 bp
  • A to G, chromosome 11 at 6,509,416 bp
  • C to A, chromosome 11 at 45,980,552 bp
  • T to C, chromosome 11 at 46,224,177 bp
  • T to G, chromosome 11 at 73,799,380 bp
  • A to G, chromosome 11 at 119,452,575 bp
  • T to C, chromosome 12 at 111,326,084 bp
  • A to G, chromosome 13 at 37,345,497 bp
  • C to A, chromosome 13 at 49,433,862 bp
  • T to C, chromosome 13 at 63,573,294 bp
  • G to A, chromosome 13 at 75,093,186 bp
  • A to T, chromosome 14 at 13,899,648 bp
  • T to C, chromosome 15 at 45,109,315 bp
  • T to G, chromosome 17 at 18,305,141 bp
  • T to C, chromosome 18 at 37,402,114 bp
  • A to G, chromosome 19 at 8,754,907 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7258 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045386-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.