Strain Name:
C57BL/6J-MtgxR7294Btlr/Mmmh
Stock Number:
045399-MU
Citation ID:
RRID:MMRRC_045399-MU
Other Names:
R7294 (G1)
Major Collection:

Strain Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Col2a, M100856, Del1, Col2a-1, Lpk, Col2, Rgsc856, Rgsc413, M100413
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Pax6
Name: paired box 6
Synonyms: Pax-6, Gsfaey11, Dey, AEY11, Dickie's small eye, 1500038E17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18508
HGNC: HGNC:8620
Homologene: 1212
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Kcnj5
Name: potassium inwardly-rectifying channel, subfamily J, member 5
Synonyms: Kir3.4, GIRK4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16521
VEGA: 9
HGNC: HGNC:6266
Homologene: 20248
Kpna4
Name: karyopherin subunit alpha 4
Synonyms: importin alpha 3, IPOA3, 1110058D08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16649
HGNC: HGNC:6397
Homologene: 20521
Gfpt2
Name: glutamine fructose-6-phosphate transaminase 2
Synonyms: GFAT2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14584
HGNC: HGNC:4242
Homologene: 68439
Tbc1d22a
Name: TBC1 domain family, member 22a
Synonyms: D15Ertd781e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223754
VEGA: 15
HGNC: HGNC:1309
Homologene: 105406
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Tara, EST478828, Mus EST 478828
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, Hbxap, p325, 4832420A03Rik, C030033M12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: HBLP1, GRAM domain, AD3, BUB2-like protein 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54610
Homologene: 31421
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, C130039F11Rik, A330049M09Rik, enaptin165, nesprin-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Tmem131
Name: transmembrane protein 131
Synonyms: D1Bwg0491e, CC28, Neg, YR-23, 2610524E03Rik, Rw1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56030
Homologene: 32428
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: SRp75, 5730499P16Rik, Sfrs4, MNCb-2616
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57317
Homologene: 25624
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109332
Homologene: 11276
Leprotl1
Name: leptin receptor overlapping transcript-like 1
Synonyms: 1520402O14Rik, 1110067H13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68192
HGNC: HGNC:6555
Homologene: 41031
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: Pdgfr-2, CD140a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Amdhd1
Name: amidohydrolase domain containing 1
Synonyms: 1300019J08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71761
Homologene: 14730
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: D16Ertd642e, 6330444M21Rik, Wdr52
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212517
Homologene: 75085
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381463
Homologene: 131277
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, Gababrbp, C330021K24Rik, 5830437M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: B230396K10Rik, Cytsb, 2810012G08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432572
Homologene: 45157
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Adamts9
Name: ADAM metallopeptidase with thrombospondin type 1 motif 9
Synonyms: 1810011L16Rik, E030027K14Rik, 8430403M15Rik, UND3, UND4, Mhdaund3, Mhdaund4, Gsfund3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101401
Homologene: 18821
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Stil
Name: Scl/Tal1 interrupting locus
Synonyms: Sil
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20460
Homologene: 2283
Bpifb9a
Name: BPI fold containing family B, member 9A
Synonyms: 4833413D08Rik, vomeromodulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71425
Homologene: 128535
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: 5530401I02Rik, LOC268884, 9530025L16Rik, 4632417D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77446
Homologene: 35276
Hinfp
Name: histone H4 transcription factor
Synonyms: DKFZp434F162, Mizf
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102423
VEGA: 9
Homologene: 9174
C5ar1
Name: complement component 5a receptor 1
Synonyms: D7Msu1, C5aR, C5r1, Cd88
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12273
HGNC: HGNC:1338
Homologene: 20413
Slc2a4
Name: solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms: Glut4, twgy, Glut-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20528
Homologene: 74381
Timd5
Name: T cell immunoglobulin and mucin domain containing 5
Synonyms: Gm12169
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 210535
Homologene: 130033
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Krt15
Name: keratin 15
Synonyms: K15, Krt1-15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16665
HGNC: HGNC:6421
Homologene: 1712
Or4c12
Name: olfactory receptor family 4 subfamily C member 12
Synonyms: Olfr1259, MOR232-9, GA_x6K02T2Q125-51376062-51375133
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258338
Homologene: 128115
Thrb
Name: thyroid hormone receptor beta
Synonyms: Thrb1, Thrb2, Nr1a2, TR beta, T3Rbeta, T3R[b], c-erbAbeta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21834
Homologene: 36025
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68274
Homologene: 130753
Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms: mHS
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15360
HGNC: HGNC:5008
Homologene: 38066
Rimkla
Name: ribosomal modification protein rimK-like family member A
Synonyms: NAAGS-II, Rimk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194237
Homologene: 18336
Cdh22
Name: cadherin 22
Synonyms: PB-cadherin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104010
Homologene: 23148
Slc26a1
Name: solute carrier family 26 (sulfate transporter), member 1
Synonyms: Sat1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231583
Homologene: 32539
Or52b3
Name: olfactory receptor family 52 subfamily B member 3
Synonyms: GA_x6K02T2PBJ9-5274337-5275287, MOR31-3, Olfr549
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259105
Homologene: 86245
Dusp13b
Name: dual specificity phosphatase 13B
Synonyms: TMDP, LMW-DSP6, TS-DSP6, LOC382853, Dusp13
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27389
Homologene: 121602
Nutm1
Name: NUT midline carcinoma, family member 1
Synonyms: Nut, BC125332
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213765
Homologene: 18185
Zfp40
Name: zinc finger protein 40
Synonyms: NTfin12, Zfp-40
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22700
Homologene: 136312
Adam1a
Name: a disintegrin and metallopeptidase domain 1a
Synonyms: Ftna, fertilin alpha, PH-30 alpha
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280668
HGNC: HGNC:187
Homologene: 73803
Naa80
Name: N(alpha)-acetyltransferase 80, NatH catalytic subunit
Synonyms: Nat6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56441
Homologene: 36325
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 36,854,847 bp
  • C to T, chromosome 1 at 39,406,762 bp
  • A to T, chromosome 1 at 90,828,283 bp
  • C to T, chromosome 1 at 150,403,887 bp
  • A to G, chromosome 2 at 65,472,341 bp
  • A to C, chromosome 2 at 89,943,724 bp
  • T to A, chromosome 2 at 105,684,901 bp
  • G to A, chromosome 2 at 112,250,056 bp
  • C to T, chromosome 2 at 154,267,696 bp
  • A to C, chromosome 2 at 165,142,093 bp
  • A to C, chromosome 3 at 69,092,623 bp
  • T to C, chromosome 3 at 87,995,524 bp
  • C to T, chromosome 3 at 98,290,895 bp
  • T to C, chromosome 3 at 102,945,262 bp
  • G to T, chromosome 4 at 43,534,399 bp
  • A to C, chromosome 4 at 52,611,903 bp
  • T to C, chromosome 4 at 115,007,283 bp
  • A to T, chromosome 4 at 119,468,466 bp
  • A to G, chromosome 4 at 131,900,461 bp
  • T to C, chromosome 5 at 37,117,460 bp
  • A to G, chromosome 5 at 75,181,651 bp
  • G to T, chromosome 5 at 108,673,832 bp
  • G to T, chromosome 5 at 121,520,005 bp
  • G to A, chromosome 6 at 92,894,289 bp
  • T to A, chromosome 6 at 121,673,582 bp
  • T to C, chromosome 7 at 16,249,025 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,920 bp
  • T to A, chromosome 7 at 102,554,953 bp
  • A to T, chromosome 8 at 34,138,852 bp
  • A to C, chromosome 9 at 32,322,749 bp
  • A to G, chromosome 9 at 44,299,270 bp
  • A to T, chromosome 9 at 78,712,635 bp
  • T to G, chromosome 9 at 107,582,983 bp
  • C to T, chromosome 9 at 123,177,921 bp
  • A to T, chromosome 10 at 5,097,483 bp
  • T to C, chromosome 10 at 93,534,439 bp
  • T to A, chromosome 11 at 46,535,612 bp
  • C to T, chromosome 11 at 49,818,608 bp
  • T to A, chromosome 11 at 62,118,337 bp
  • T to C, chromosome 11 at 69,945,399 bp
  • T to A, chromosome 11 at 100,132,022 bp
  • A to G, chromosome 14 at 17,826,963 bp
  • A to G, chromosome 14 at 21,733,714 bp
  • C to T, chromosome 15 at 78,973,976 bp
  • T to A, chromosome 15 at 86,311,835 bp
  • A to G, chromosome 15 at 97,987,287 bp
  • A to T, chromosome 16 at 32,756,461 bp
  • T to C, chromosome 16 at 33,726,489 bp
  • A to G, chromosome 16 at 44,404,893 bp
  • A to T, chromosome 17 at 8,757,021 bp
  • A to G, chromosome 17 at 23,176,437 bp
  • G to A, chromosome 17 at 24,321,009 bp
  • A to G, chromosome 18 at 25,132,980 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7294 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045399-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.