Strain Name:
C57BL/6J-MtgxR7302Btlr/Mmmh
Stock Number:
045406-MU
Citation ID:
RRID:MMRRC_045406-MU
Other Names:
R7302 (G1)
Major Collection:

Strain Information

Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77569
Homologene: 18953
Ndufa7
Name: NADH:ubiquinone oxidoreductase subunit A7
Synonyms: 2400007M02Rik, 14.5kDa, NADH oxidoreductase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66416
HGNC: HGNC:7691
Homologene: 37994
Egln2
Name: egl-9 family hypoxia-inducible factor 2
Synonyms: SM-20, Ier4, 0610011A13Rik, Phd1, Hif-p4h-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 112406
Homologene: 14204
Zfp13
Name: zinc finger protein 13
Synonyms: Krox-8, Zfp-13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22654
VEGA: 17
Homologene: 2580
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: SAP155, Prp10, SF3b155, 2810001M05Rik, Targ4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 81898
Homologene: 6696
Fancl
Name: Fanconi anemia, complementation group L
Synonyms: 2010322C19Rik, gcd, Pog, Phf9, B230118H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67030
Homologene: 9987
Bcl7a
Name: B cell CLL/lymphoma 7A
Synonyms: 4432415N06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77045
HGNC: HGNC:1004
Homologene: 10869
Ppp1r10
Name: protein phosphatase 1, regulatory subunit 10
Synonyms: 2610025H06Rik, D17Ertd808e, PNUTS
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52040
HGNC: HGNC:9284
Homologene: 2033
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Mob1b
Name: MOB kinase activator 1B
Synonyms: 1110003E08Rik, Mobkl1a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68473
Homologene: 61676
Surf2
Name: surfeit gene 2
Synonyms: Surf-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20931
Homologene: 8430
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, LOC380767, A630028O16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Tnks1bp1
Name: tankyrase 1 binding protein 1
Synonyms: TAB182
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228140
Homologene: 14117
Sbsn
Name: suprabasin
Synonyms: 1110005D19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 282619
Homologene: 17900
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: NHE2, 4932415O19Rik, 2210416H12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226999
Homologene: 20661
Pnp
Name: purine-nucleoside phosphorylase
Synonyms: Np-2, Np-1, Np, Pnp, Pnp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18950
HGNC: HGNC:7892
Homologene: 227
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Dhx36
Name: DEAH-box helicase 36
Synonyms: Ddx36, 2810407E23Rik, RHAU
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72162
Homologene: 6356
Ust
Name: uronyl-2-sulfotransferase
Synonyms: D930010O20Rik, UA2OST
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 338362
VEGA: 10
Homologene: 4174
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: 4930505G06Rik, A930002K18Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Dennd5a
Name: DENN domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19347
Homologene: 14584
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233437
Homologene: 115466
Haus1
Name: HAUS augmin-like complex, subunit 1
Synonyms: spindle associated, HEI-C, Ccdc5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225745
VEGA: 18
Homologene: 15516
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Eri2
Name: exoribonuclease 2
Synonyms: 4933424N09Rik, Exod1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71151
Homologene: 12383
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327963
Homologene: 88945
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57435
Homologene: 69311
Cotl1
Name: coactosin like F-actin binding protein 1
Synonyms: 2010004C08Rik, 1810074P22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72042
Homologene: 10898
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Hmbox1
Name: homeobox containing 1
Synonyms: F830020C16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219150
Homologene: 11589
Ccdc102a
Name: coiled-coil domain containing 102A
Synonyms: LOC234582
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234582
Homologene: 13240
Vmn1r77
Name: vomeronasal 1 receptor 77
Synonyms: Gm6935
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628946
Homologene: 103843
Fancf
Name: Fanconi anemia, complementation group F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100040608
HGNC: HGNC:3587
Homologene: 75185
4930474N05Rik
Name: RIKEN cDNA 4930474N05 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218921
Homologene: 138428
Mylk4
Name: myosin light chain kinase family, member 4
Synonyms: EG238564
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238564
Homologene: 66243
Zfp865
Name: zinc finger protein 865
Synonyms: 6430526N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319748
Homologene: 19652
Sgsh
Name: N-sulfoglucosamine sulfohydrolase (sulfamidase)
Synonyms: sulphamidase, 4632406A19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27029
Homologene: 167
Ivd
Name: isovaleryl coenzyme A dehydrogenase
Synonyms: 6720455E18Rik, 1300016K07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56357
HGNC: HGNC:6186
Homologene: 1676
Mbd3l2
Name: methyl-CpG binding domain protein 3-like 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234988
VEGA: 9
Homologene: 44896
Nectin4
Name: nectin cell adhesion molecule 4
Synonyms: nectin 4, Prr4, 1200017F15Rik, Pvrl4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71740
Homologene: 32744
Slc25a10
Name: solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms: Dic
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27376
Homologene: 6519
Fignl2
Name: fidgetin-like 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 668225
VEGA: 15
Homologene: 28523
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 40,767,668 bp
  • A to G, chromosome 1 at 55,016,790 bp
  • T to C, chromosome 1 at 139,739,698 bp
  • G to T, chromosome 1 at 171,386,635 bp
  • G to T, chromosome 2 at 26,918,882 bp
  • T to C, chromosome 2 at 85,052,354 bp
  • T to C, chromosome 2 at 118,871,504 bp
  • A to T, chromosome 2 at 177,193,855 bp
  • T to C, chromosome 3 at 62,479,393 bp
  • T to A, chromosome 3 at 109,832,617 bp
  • T to C, chromosome 4 at 58,834,593 bp
  • T to C, chromosome 5 at 32,979,508 bp
  • A to T, chromosome 5 at 66,959,599 bp
  • A to G, chromosome 5 at 88,753,177 bp
  • T to A, chromosome 5 at 123,344,694 bp
  • A to G, chromosome 6 at 70,588,755 bp
  • A to G, chromosome 6 at 113,409,285 bp
  • A to G, chromosome 7 at 5,029,253 bp
  • C to T, chromosome 7 at 12,042,056 bp
  • A to G, chromosome 7 at 27,164,885 bp
  • T to C, chromosome 7 at 30,751,884 bp
  • T to G, chromosome 7 at 50,856,269 bp
  • C to A, chromosome 7 at 51,861,704 bp
  • A to G, chromosome 7 at 85,005,215 bp
  • A to T, chromosome 7 at 109,905,699 bp
  • T to A, chromosome 7 at 119,786,786 bp
  • A to G, chromosome 8 at 94,913,438 bp
  • T to G, chromosome 8 at 119,810,301 bp
  • G to A, chromosome 9 at 18,444,442 bp
  • A to G, chromosome 9 at 119,806,951 bp
  • A to G, chromosome 10 at 8,518,209 bp
  • C to T, chromosome 10 at 127,538,987 bp
  • A to T, chromosome 11 at 26,403,363 bp
  • T to A, chromosome 11 at 74,085,379 bp
  • A to G, chromosome 11 at 119,347,699 bp
  • G to T, chromosome 11 at 120,491,956 bp
  • A to G, chromosome 12 at 21,355,693 bp
  • A to T, chromosome 12 at 79,251,168 bp
  • A to T, chromosome 13 at 32,720,565 bp
  • C to T, chromosome 14 at 36,095,349 bp
  • G to A, chromosome 14 at 50,950,947 bp
  • A to G, chromosome 14 at 52,149,555 bp
  • T to C, chromosome 14 at 64,828,666 bp
  • T to A, chromosome 15 at 4,796,950 bp
  • T to C, chromosome 15 at 101,053,378 bp
  • C to T, chromosome 17 at 23,581,062 bp
  • T to C, chromosome 17 at 33,829,713 bp
  • C to T, chromosome 17 at 34,678,901 bp
  • T to G, chromosome 17 at 35,930,881 bp
  • C to T, chromosome 17 at 45,643,812 bp
  • T to A, chromosome 17 at 56,102,330 bp
  • T to C, chromosome 18 at 77,760,966 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7302 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045406-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.